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| | thrA | Homoserine dehydrogenase; KEGG: set:SEN0001 0. thrA; bifunctional aspartokinase I/homeserine dehydrogenase I; K12524 bifunctional aspartokinase/homoserine dehydrogenase 1; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0002; thrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa) |
| | EHY68979.1 | Threonine synthase; KEGG: sed:SeD_A0004 1.2e-224 thrC; threonine synthase K01733; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0004; thrC. (428 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | carA | KEGG: see:SNSL254_A0070 5.5e-199 carA; carbamoyl-phosphate synthase, small subunit K01956; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0066; carA; Belongs to the CarA family. (382 aa) |
| | carB | KEGG: ses:SARI_02937 0. carB; carbamoyl phosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; locus tag in AE006468 is STM0067; carB; Belongs to the CarB family. (1074 aa) |
| | EHY69046.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (159 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (523 aa) |
| | EHY69078.1 | KEGG: spq:SPAB_00147 1.0e-300 acetolactate synthase 3 catalytic subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: CytoplasmicMembrane, score: 8.46; locus tag in AE006468 is STM0116; ilvI. (566 aa) |
| | EHY69079.1 | KEGG: see:SNSL254_A0129 7.2e-78 ilvH; acetolactate synthase, small subunit, isozyme III K01653; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0117; ilvH. (164 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | mtnN | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...] (232 aa) |
| | dapD | KEGG: sed:SeD_A0234 5.6e-142 dapD; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase K00674; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0213; dapD; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | aroL | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (181 aa) |
| | aroM | AroM protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0390; aroM. (225 aa) |
| | EHY69381.1 | Pyridoxal-phosphate dependent enzyme; KEGG: set:SEN0440 3.4e-190 putative lyase; K01738 cysteine synthase A; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0458. (351 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | asnB | Asparagine synthase; KEGG: spq:SPAB_02863 1.1e-301 asnB; asparagine synthetase B; K01953 asparagine synthase (glutamine-hydrolysing); Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0680; asnB. (554 aa) |
| | aroG | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (393 aa) |
| | EHY69716.1 | Glycosyl transferase family, helical bundle domain protein; KEGG: mms:mma_0486 6.3e-63 trpD2; glycosyl transferase family protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0822; ybiB. (324 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | serC | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (399 aa) |
| | putA | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1320 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (347 aa) |
| | gdhA_2 | Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: seh:SeHA_C1426 6.8e-240 gdhA; glutamate dehydrogenase; K00262 glutamate dehydrogenase (NADP+); Psort location: OuterMembrane, score: 9.92; locus tag in AE006468 is STM1299; gdhA; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | astC | N-succinyldiaminopimelate- aminotransferase/acetylornithine transaminase protein; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily. (392 aa) |
| | aroH | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (233 aa) |
| | ydiB | Quinate/shikimate dehydrogenase; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. (288 aa) |
| | EHY70645.1 | KEGG: set:SEN1311 7.3e-275 trpE; anthranilate synthase component I; K01657 anthranilate synthase component I; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1723; trpE. (520 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa) |
| | trpF | KEGG: spq:SPAB_01520 6.2e-230 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; K01609 indole-3-glycerol phosphate synthase K01817; locus tag in AE006468 is STM1725; trpC; Belongs to the TrpC family. (452 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (289 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | hisC | KEGG: spq:SPAB_00960 1.2e-187 histidinol-phosphate aminotransferase; K00817 histidinol-phosphate aminotransferase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2073; hisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa) |
| | hisB | Histidinol-phosphatase; KEGG: sea:SeAg_B2199 2.4e-189 hisB; imidazole glycerol-phosphate dehydratase/histidinol phosphatase K01089; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2074; hisB; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisA | KEGG: see:SNSL254_A2255 7.9e-120 hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2076; hisA. (245 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisI | phosphoribosyl-ATP diphosphatase; KEGG: sew:SeSA_A2306 7.9e-104 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein K11755; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2078; hisI; In the N-terminal section; belongs to the PRA-CH family. (203 aa) |
| | EHY71106.1 | KEGG: gur:Gura_1692 2.6e-82 imidazole glycerol phosphate synthase subunit HisF; K02500 cyclase HisF; Psort location: Cytoplasmic, score: 9.26. (262 aa) |
| | EHY71107.1 | KEGG: vvy:VV0355 1.5e-61 hisH; imidazole glycerol phosphate synthase subunit HisH; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 9.26. (204 aa) |
| | wcaB | Bacterial transferase hexapeptide repeat protein; KEGG: spq:SPAB_00916 4.0e-84 putative colanic acid biosynthesis acetyltransferase WcaB; K03819 putative colanic acid biosynthesis acetyltransferase WcaB; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM2114; wcaB; Belongs to the transferase hexapeptide repeat family. (162 aa) |
| | gtdA | KEGG: sew:SeSA_A2417 4.4e-190 gtdA; gentisate 1,2-dioxygenase K00450; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2178. (345 aa) |
| | EHY71427.1 | KEGG: sty:STY2590 5.5e-254 putative amino acid decarboxylase; K01586 diaminopimelate decarboxylase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2360. (465 aa) |
| | EHY71437.1 | Semialdehyde dehydrogenase, dimerization domain protein; KEGG: see:SNSL254_A2557 2.7e-174 aspartate-semialdehyde dehydrogenase family protein; K00133 aspartate-semialdehyde dehydrogenase; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM2369; usg. (337 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | cysZ | Putative sulfate transport protein CysZ; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (253 aa) |
| | cysK | Cysteine synthase A; KEGG: see:SNSL254_A2623 1.7e-165 cysK; cysteine synthase A K01738; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2430; cysK; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | cysM | Cysteine synthase B; KEGG: sea:SeAg_B2585 1.3e-151 cysM; cysteine synthase B K12339; locus tag in AE006468 is STM2440; cysM; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | pheA | Chorismate mutase; KEGG: seg:SG2645 1.3e-199 pheA; bifunctional chorismate mutase/prephenate dehydratase; K04093 chorismate mutase K04518; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2667; pheA. (386 aa) |
| | tyrA | Chorismate mutase; KEGG: spq:SPAB_03380 6.0e-193 tyrA; bifunctional chorismate mutase/prephenate dehydrogenase; K04092 chorismate mutase K04517; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2669; tyrA. (373 aa) |
| | EHY68304.1 | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa) |
| | cysI | Sulfite reductase hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa) |
| | cysJ | Sulfite reductase [NADPH] flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. (599 aa) |
| | argA | Amino-acid N-acetyltransferase; KEGG: stt:t2900 2.1e-229 argA; N-acetylglutamate synthase K00619; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2992; argA; Belongs to the acetyltransferase family. ArgA subfamily. (443 aa) |
| | lysA_1 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | serA | KEGG: spq:SPAB_03816 2.1e-213 D-3-phosphoglycerate dehydrogenase; K00058 D-3-phosphoglycerate dehydrogenase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3062; serA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa) |
| | argG | KEGG: ses:SARI_04334 4.0e-235 argininosuccinate synthase; K01940 argininosuccinate synthase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3290; argG; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa) |
| | EHY68918.1 | Class II glutamine amidotransferase; KEGG: stt:t3247 0. gltB; glutamate synthase subunit alpha K00265; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3330; gltB. (1486 aa) |
| | EHY68919.1 | KEGG: spq:SPAB_04154 4.9e-253 gltD; glutamate synthase subunit beta; K00266 glutamate synthase (NADPH/NADH) small chain; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3331; gltD. (472 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (156 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | argD | N-succinyldiaminopimelate- aminotransferase/acetylornithine transaminase protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (342 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (161 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa) |
| | EHY68003.1 | KEGG: sec:SC3622 1.1e-143 cysE; serine acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3699; cysE; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | ilvN | KEGG: ses:SARI_03854 2.7e-46 acetolactate synthase 1 regulatory subunit; K01653 acetolactate synthase I/III small subunit; locus tag in AE006468 is STM3795; ilvN. (96 aa) |
| | ilvB | KEGG: sei:SPC_3877 5.4e-295 ilvB; acetolactate synthase large subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3796; ilvB. (562 aa) |
| | asnA | Aspartate--ammonia ligase; KEGG: spq:SPAB_04821 5.4e-176 asparagine synthetase AsnA; K01914 aspartate--ammonia ligase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3877; asnA. (330 aa) |
| | EHY68204.1 | KEGG: ses:SARI_03751 1.0e-284 acetolactate synthase 2 catalytic subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3901; ilvG. (548 aa) |
| | ilvM | KEGG: sed:SeD_A4292 8.0e-40 ilvM; acetolactate synthase 2 regulatory subunit K11258; locus tag in AE006468 is STM3902; ilvM. (87 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa) |
| | ilvD | KEGG: seh:SeHA_C4235 0. ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3904; ilvD; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvA | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | ilvY | HTH-type transcriptional activator IlvY; KEGG: shn:Shewana3_3435 1.2e-15 LysR family transcriptional regulator; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3908; ilvY; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | metR | KEGG: spl:Spea_0904 1.7e-15 LysR family transcriptional regulator; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3964; metR; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa) |
| | glnA | KEGG: sec:SC3899 3.4e-254 glnA; glutamine synthetase K01915; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM4007; glnA. (469 aa) |
| | EHY67655.1 | KEGG: cko:CKO_03091 2.7e-44 hypothetical protein; K01714 dihydrodipicolinate synthase. (133 aa) |
| | metJ | Met Apo-repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa) |
| | metL | Homoserine dehydrogenase; KEGG: sty:STY3768 0. metL, metM; bifunctional aspartate kinase II/homoserine dehydrogenase II K12525; Psort location: CytoplasmicMembrane, score: 9.82; locus tag in AE006468 is STM4101; metL; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) |
| | metF | KEGG: stt:t3511 5.8e-156 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM4105; metF. (296 aa) |
| | argE | KEGG: set:SEN3915 1.6e-208 argE; acetylornithine deacetylase; K01438 acetylornithine deacetylase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM4120; argE. (383 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa) |
| | argH | Argininosuccinate lyase; KEGG: spq:SPAB_05108 3.8e-239 argininosuccinate lyase; K01755 argininosuccinate lyase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM4123; argH. (457 aa) |
| | metAS | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa) |
| | EHY67160.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa) |
| | lysC | Aspartate kinase, monofunctional class; Locus tag in AE006468 is STM4220; lysC; Belongs to the aspartokinase family. (449 aa) |
| | alr-2 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (359 aa) |
| | ridA | Putative endoribonuclease L-PSP; Locus tag in AE006468 is STM4458; yjgF. (128 aa) |
| | argR_2 | Arginine repressor protein; Regulates arginine biosynthesis genes. (162 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa) |
| | argF-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa) |
| | EHY67430.1 | Acetyltransferase, GNAT family; Locus tag in AE006468 is STM4473; yjgM. (158 aa) |
| | EHY67433.1 | Hypothetical protein. (51 aa) |
| | EHY67434.1 | Hypothetical protein. (44 aa) |
| | serB | Phosphoserine phosphatase SerB; Locus tag in AE006468 is STM4578; serB. (294 aa) |
