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| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (304 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | EHY71403.1 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | yfbR | HD domain protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa) |
| | cinA | Competence/damage-inducible protein CinA protein; KEGG: dre:445492 2.3e-09 flad1; FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) K00953; locus tag in AE006468 is STM2293; Belongs to the CinA family. (398 aa) |
| | nrdB | KEGG: ses:SARI_00614 5.3e-201 nrdB; ribonucleotide-diphosphate reductase subunit beta; K00526 ribonucleoside-diphosphate reductase beta chain; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2278; nrdB. (376 aa) |
| | EHY71294.1 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (179 aa) |
| | fbaB | Deoxyribose-phosphate aldolase; KEGG: spt:SPA0711 1.1e-184 fbaB; fructose-bisphosphate aldolase K01623; locus tag in AE006468 is STM2141; fbaB. (350 aa) |
| | udk | Uridine kinase; KEGG: sed:SeD_A2463 2.2e-108 udk; uridine kinase K00876; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2122; udk. (213 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa) |
| | EHY71060.1 | Molybdenum cofactor synthesis domain protein; KEGG: psp:PSPPH_2159 2.0e-105 isocitrate/isopropylmalate family dehydrogenase K00052; Psort location: Cytoplasmic, score: 9.97. (725 aa) |
| | fliI | Flagellar protein export ATPase FliI; KEGG: sed:SeD_A1270 1.0e-238 fliI; flagellum-specific ATP synthase K02412; Psort location: Cytoplasmic, score: 9.12; locus tag in AE006468 is STM1972; fliI. (456 aa) |
| | pyk | Pyruvate kinase; Locus tag in AE006468 is STM1888; pykA; Belongs to the pyruvate kinase family. (480 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa) |
| | yciA | Thioesterase family protein; KEGG: stt:t1648 7.6e-67 yciA; acyl-CoA thioester hydrolase; K10806 acyl-CoA thioesterase YciA; locus tag in AE006468 is STM1736; yciA. (133 aa) |
| | EHY69015.1 | KEGG: sei:SPC_0047 2.9e-152 ribF; hypothetical protein; K11753 riboflavin kinase / FMN adenylyltransferase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0045; ribF. (295 aa) |
| | carA | KEGG: see:SNSL254_A0070 5.5e-199 carA; carbamoyl-phosphate synthase, small subunit K01956; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0066; carA; Belongs to the CarA family. (382 aa) |
| | carB | KEGG: ses:SARI_02937 0. carB; carbamoyl phosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; locus tag in AE006468 is STM0067; carB; Belongs to the CarB family. (1074 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | guaC | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa) |
| | nadC | Nicotinate-nucleotide diphosphorylase; KEGG: spq:SPAB_00181 1.9e-157 quinolinate phosphoribosyltransferase; K00767 nicotinate-nucleotide pyrophosphorylase (carboxylating); Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0145; nadC; Belongs to the NadC/ModD family. (311 aa) |
| | aceE | Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | aceF | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (625 aa) |
| | EHY69143.1 | KEGG: spq:SPAB_00209 2.4e-93 hypoxanthine-guanine phosphoribosyltransferase; K00760 hypoxanthine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0170; hpt; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (198 aa) |
| | dgt | Putative dGTPase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (505 aa) |
| | pyrH | UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | EHY69201.1 | Glyoxalase family protein; KEGG: chu:CHU_2533 4.0e-45 gloA; lactoylglutathione lyase K08234; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0235; yaeR. (129 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa) |
| | tesB | acyl-CoA thioesterase II; KEGG: ses:SARI_02469 1.5e-150 acyl-CoA thioesterase II; K10805 acyl-CoA thioesterase II; locus tag in AE006468 is STM0464; tesB. (286 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (235 aa) |
| | ushA | KEGG: spq:SPAB_03073 3.3e-295 ushA; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; K11751 5'-nucleotidase / UDP-sugar diphosphatase; Psort location: Periplasmic, score: 10.00; locus tag in AE006468 is STM0494; ushA; Belongs to the 5'-nucleotidase family. (550 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (341 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | uspG | Universal stress family protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0614; ybdQ. (142 aa) |
| | citF | KEGG: sew:SeSA_A0780 9.5e-266 citF; citrate lyase, alpha subunit K01643; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0621; citF. (509 aa) |
| | EHY69533.1 | KEGG: see:SNSL254_A0676 1.0e-151 citE; citrate (pro-3S)-lyase, beta subunit K01644; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0622; citE; Belongs to the HpcH/HpaI aldolase family. (302 aa) |
| | citD | Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase. (98 aa) |
| | nadD | Nicotinate nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (216 aa) |
| | corC | Transporter associated domain protein; KEGG: eci:UTI89_C0656 1.5e-148 ybeX; putative transport protein K06189; Psort location: CytoplasmicMembrane, score: 7.88; locus tag in AE006468 is STM0667; ybeX. (292 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (347 aa) |
| | prs | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (280 aa) |
| | tdk | Thymidine kinase; KEGG: see:SNSL254_A1877 2.3e-104 tdk; thymidine kinase K00857; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM1750; tdk. (205 aa) |
| | EHY69005.1 | 5'-nucleotidase protein; KEGG: ect:ECIAI39_3051 3.0e-166 putative 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; locus tag in AE006468 is STM0033; Belongs to the 5'-nucleotidase family. (520 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa) |
| | ygaD_2 | Competence/damage-inducible protein CinA protein; KEGG: rsp:RSP_1822 6.6e-11 NH(3)-dependent NAD(+) synthetase K03743; locus tag in AE006468 is STM1514; ydeJ; Belongs to the CinA family. (175 aa) |
| | add | Adenosine deaminase; KEGG: seh:SeHA_C1633 8.2e-173 add; adenosine deaminase K01488; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1463; add; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa) |
| | purR | Periplasmic binding protein and sugar binding domain of the LacI family protein; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (341 aa) |
| | EHY70277.1 | KEGG: ses:SARI_01567 1.0e-220 type III secretion system ATPase; K03224 ATP synthase in type III secretion protein SctN; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1415; ssaN. (433 aa) |
| | pykF | Pyruvate kinase; KEGG: sei:SPC_2351 8.4e-242 pykF; pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1378; pykF. (470 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (275 aa) |
| | EHY70164.1 | Isochorismatase family protein; KEGG: seh:SeHA_C1420 2.8e-115 nicotinamidase/pyrazinamidase; K01440 nicotinamidase K08281; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM1293; pncA. (218 aa) |
| | EHY70161.1 | Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: sek:SSPA1445 3.4e-174 glyceraldehyde 3-phosphate dehydrogenase A; K00134 glyceraldehyde 3-phosphate dehydrogenase; Psort location: Cytoplasmic, score: 10.00; locus tag in AE006468 is STM1290; gapA; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | EHY70073.1 | Adenylosuccinate lyase; KEGG: stm:STM1232 5.2e-242 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1232; purB. (456 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) |
| | EHY70021.1 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (194 aa) |
| | pyrC | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (400 aa) |
| | cmk | Cytidylate kinase; KEGG: spq:SPAB_02536 1.6e-112 cmk; cytidylate kinase; K00945 cytidylate kinase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0980; cmk. (227 aa) |
| | grxA | Glutaredoxin, GrxA family; KEGG: tcx:Tcr_0139 1.4e-07 glutaredoxin-like region; K03386 peroxiredoxin (alkyl hydroperoxide reductase subunit C); Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0872; grxA. (87 aa) |
| | gpmA | Phosphoglycerate mutase 1 family protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | gpmB | Phosphoglycerate mutase family protein; Locus tag in AE006468 is STM4585; gpmB; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |
| | yjjX | Hypothetical protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (171 aa) |
| | nadR | Nicotinamide-nucleotide adenylyltransferase; Locus tag in AE006468 is STM4580; nadR. (410 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (271 aa) |
| | pyrB | Aspartate carbamoyltransferase; Locus tag in AE006468 is STM4460; pyrB; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa) |
| | nrdG | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa) |
| | cpdB | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Locus tag in AE006468 is STM4403; cpdB; Belongs to the 5'-nucleotidase family. (647 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | nnrE | YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...] (514 aa) |
| | acs | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa) |
| | pgi | Glucose-6-phosphate isomerase; Locus tag in AE006468 is STM4221; pgi; Belongs to the GPI family. (549 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Locus tag in AE006468 is STM4176; purH. (529 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Locus tag in AE006468 is STM4175; purD. (429 aa) |
| | nudC | NAD(+) diphosphatase; Locus tag in AE006468 is STM4166; yjaD; Belongs to the Nudix hydrolase family. NudC subfamily. (257 aa) |
| | coaA | Pantothenate kinase; Locus tag in AE006468 is STM4139; coaA. (318 aa) |
| | EHY67717.1 | 5'-nucleotidase protein; KEGG: efe:EFER_3829 1.7e-259 putative phosphoesterase; Psort location: Periplasmic, score: 9.44; locus tag in AE006468 is STM4104; Belongs to the 5'-nucleotidase family. (518 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | EHY67635.1 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (326 aa) |
| | EHY68277.1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa) |
| | cyaA | KEGG: ses:SARI_03713 0. cyaA; adenylate cyclase; K05851 adenylate cyclase, class 1; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3939; cyaA; Belongs to the adenylyl cyclase class-1 family. (848 aa) |
| | gppA | Ppx/GppA phosphatase family protein; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (499 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (271 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (79 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (177 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (460 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa) |
| | spoT | Guanosine 3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (703 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | dut | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | coaBC | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (407 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | grxC | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. (83 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | yhdE | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa) |
| | EHY68821.1 | Hypothetical protein; KEGG: rrj:RrIowa_0485 0.0038 zinc metalloprotease K07043; locus tag in AE006468 is STM3221; ygjP. (165 aa) |
| | hit | Hypothetical protein; Locus tag in AE006468 is STM3167. (114 aa) |
| | rdgB | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa) |
| | yqgE | Hypothetical protein; Locus tag in AE006468 is STM3096; yqgE; Belongs to the UPF0301 (AlgH) family. (196 aa) |
| | pgk | Phosphoglycerate kinase; KEGG: seh:SeHA_C3306 3.5e-197 pgk; phosphoglycerate kinase K00927; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3069; pgk. (387 aa) |
| | fba | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | scpC_2 | Succinate CoA transferase; KEGG: eum:ECUMN_3264 1.5e-235 ygfH; propionyl-CoA:succinate-CoA transferase. (492 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | EHY68519.1 | GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa) |
| | mazG | MazG family protein; KEGG: sea:SeAg_B3087 2.7e-133 mazG; nucleoside triphosphate pyrophosphohydrolase; K02428 nucleoside-triphosphate pyrophosphatase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2954; mazG. (263 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | EHY68511.1 | Hypothetical protein; KEGG: sbo:SBO_2660 4.3e-32 eno; phosphopyruvate hydratase K01689; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM2952; eno. (75 aa) |
| | surE | 5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (250 aa) |
| | EHY68450.1 | Invasion protein InvC; Locus tag in AE006468 is STM2894; invC. (431 aa) |
| | SBOV28861 | Hypothetical protein; Locus tag in AE006468 is STM2860; ygbA. (114 aa) |
| | EHY68384.1 | Competence/damage-inducible protein CinA protein; KEGG: cco:CCC13826_0279 3.8e-24 fadD; long-chain-fatty-acid--CoA ligase K03743; locus tag in AE006468 is STM2830; ygaD; Belongs to the CinA family. (166 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa) |
| | ppnK | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | EHY71661.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (540 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa) |
| | asrB | KEGG: set:SEN2529 5.0e-141 asrB; anaerobic sulfite reductase subunit B; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2549; asrB. (259 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | imdH | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | guaA | GMP synthase protein; Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: stm:STM2499.S 7.5e-186 purM; phosphoribosylaminoimidazole synthetase K01933; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2499; purM. (350 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | purC | KEGG: seg:SG2517 2.5e-123 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2487; purC; Belongs to the SAICAR synthetase family. (237 aa) |
| | glk | Glucokinase; KEGG: sec:SC2406 1.5e-171 glk; glucokinase K00845; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2403; glk; Belongs to the bacterial glucokinase family. (321 aa) |
