STRINGSTRING
norV norV cysJ cysJ mioC_1 mioC_1 EHY68602.1 EHY68602.1 EHY68819.1 EHY68819.1 msrQ msrQ dusB dusB lldD lldD coaBC coaBC mioC mioC dusA dusA hemG hemG kefF kefF fldA fldA hpaC hpaC wrbA wrbA EHY70297.1 EHY70297.1 pdxH pdxH rsxG rsxG EHY70508.1 EHY70508.1 acpD acpD EHY70556.1 EHY70556.1 dusC dusC EHY71351.1 EHY71351.1 EHY71387.1 EHY71387.1 nrdI nrdI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
norVRubredoxin; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. (479 aa)
cysJSulfite reductase [NADPH] flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. (599 aa)
mioC_1Flavodoxin; KEGG: bta:507991 2.8e-13 MTRR; 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; K00597 [methionine synthase] reductase; locus tag in AE006468 is STM2963. (149 aa)
EHY68602.1Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. (173 aa)
EHY68819.12,4-dienoyl-CoA reductase; KEGG: sea:SeAg_B3406 0. FAD/FMN-binding/pyridine nucleotide-disulphide oxidoreductase family protein; K00219 2,4-dienoyl-CoA reductase (NADPH2); Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3219; fadH. (672 aa)
msrQFerric reductase like transmembrane component; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipopr [...] (199 aa)
dusBTIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (281 aa)
lldDL-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (396 aa)
coaBCPhosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (407 aa)
mioCFlavodoxin; KEGG: sab:SAB2494c 1.1e-12 cysJ; sulfite reductase flavoprotein K00380; locus tag in AE006468 is STM3875; mioC. (147 aa)
dusAtRNA dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (339 aa)
hemGKEGG: ses:SARI_03672 1.3e-94 hemG; protoporphyrinogen oxidase; K00230 protoporphyrinogen oxidase; locus tag in AE006468 is STM3987; hemG. (181 aa)
kefFFlavodoxin-like fold protein; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC; Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily. (176 aa)
fldAFlavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. (209 aa)
hpaC4-hydroxyphenylacetate 3-monooxygenase, reductase component; KEGG: spt:SPA1752 2.3e-88 hpaC; 4-hydroxyphenylacetate 3-monooxygenase coupling protein; K00484 4-hydroxyphenylacetate-3-hydroxylase small chain; locus tag in AE006468 is STM1098; hpaC. (170 aa)
wrbANAD(P)H:quinone oxidoreductase, type IV; KEGG: sed:SeD_A1194 1.9e-102 wrbA; TrpR binding protein WrbA K03809; locus tag in AE006468 is STM1119; wraB. (198 aa)
EHY70297.1Oxidoreductase, FAD/FMN-binding protein; KEGG: set:SEN1611 7.7e-193 nemA; N-ethylmaleimide reductase K10680; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1436; nemA. (365 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa)
rsxGElectron transport complex protein RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the RnfG family. (206 aa)
EHY70508.1Dehydrogenase, FMN-dependent; KEGG: lpl:lp_3586 2.7e-103 lox; lactate oxidase K00119; locus tag in AE006468 is STM1620. (400 aa)
acpDNAD(P)H dehydrogenase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family. (201 aa)
EHY70556.1Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.86; locus tag in AE006468 is STM1662; ynaJ. (82 aa)
dusCTIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (312 aa)
EHY71351.1KEGG: sew:SeSA_A2512 7.3e-291 glpA; sn-glycerol-3-phosphate dehydrogenase subunit A K00111; Psort location: Cytoplasmic, score: 9.12; locus tag in AE006468 is STM2284; glpA; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa)
EHY71387.1NADH oxidoreductase, F subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (445 aa)
nrdINrdI protein; Probably involved in ribonucleotide reductase function. (136 aa)
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.