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| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa) |
| | mogA | KEGG: hpa:HPAG1_0784 9.9e-42 mogA; molybdenum cofactor biosynthesis protein K03831; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0008; mog. (196 aa) |
| | EHY69005.1 | 5'-nucleotidase protein; KEGG: ect:ECIAI39_3051 3.0e-166 putative 5'-nucleotidase; Psort location: Periplasmic, score: 9.76; locus tag in AE006468 is STM0033; Belongs to the 5'-nucleotidase family. (520 aa) |
| | EHY69015.1 | KEGG: sei:SPC_0047 2.9e-152 ribF; hypothetical protein; K11753 riboflavin kinase / FMN adenylyltransferase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0045; ribF. (295 aa) |
| | lytB | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (316 aa) |
| | carA | KEGG: see:SNSL254_A0070 5.5e-199 carA; carbamoyl-phosphate synthase, small subunit K01956; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0066; carA; Belongs to the CarA family. (382 aa) |
| | carB | KEGG: ses:SARI_02937 0. carB; carbamoyl phosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; locus tag in AE006468 is STM0067; carB; Belongs to the CarB family. (1074 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa) |
| | araD | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). (231 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (500 aa) |
| | araB | L-ribulokinase; KEGG: sew:SeSA_A0114 0. araB; ribulokinase K00853; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM0103; araB. (569 aa) |
| | lpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | guaC | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa) |
| | nadC | Nicotinate-nucleotide diphosphorylase; KEGG: spq:SPAB_00181 1.9e-157 quinolinate phosphoribosyltransferase; K00767 nicotinate-nucleotide pyrophosphorylase (carboxylating); Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0145; nadC; Belongs to the NadC/ModD family. (311 aa) |
| | aceE | Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | aceF | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (625 aa) |
| | EHY69143.1 | KEGG: spq:SPAB_00209 2.4e-93 hypoxanthine-guanine phosphoribosyltransferase; K00760 hypoxanthine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0170; hpt; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (198 aa) |
| | dgt | Putative dGTPase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (505 aa) |
| | pyrH | UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (427 aa) |
| | EHY69188.1 | Phosphatidate cytidylyltransferase; KEGG: stt:t0223 1.8e-152 cdsA; CDP-diglyceride synthase K00981; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM0222; cdsA; Belongs to the CDS family. (285 aa) |
| | lpxD | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (151 aa) |
| | lpxA | acyl-[acyl-carrier-protein]-UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa) |
| | lpxB | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (382 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | EHY69201.1 | Glyoxalase family protein; KEGG: chu:CHU_2533 4.0e-45 gloA; lactoylglutathione lyase K08234; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0235; yaeR. (129 aa) |
| | gmhA | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (192 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | EHY69351.1 | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (168 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | tesB | acyl-CoA thioesterase II; KEGG: ses:SARI_02469 1.5e-150 acyl-CoA thioesterase II; K10805 acyl-CoA thioesterase II; locus tag in AE006468 is STM0464; tesB. (286 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (235 aa) |
| | ushA | KEGG: spq:SPAB_03073 3.3e-295 ushA; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; K11751 5'-nucleotidase / UDP-sugar diphosphatase; Psort location: Periplasmic, score: 10.00; locus tag in AE006468 is STM0494; ushA; Belongs to the 5'-nucleotidase family. (550 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (341 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | frlB_1 | SIS domain protein; KEGG: fnu:FN0627 1.5e-31 glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0572. (328 aa) |
| | EHY69486.1 | SIS domain protein; KEGG: lwe:lwe2019 5.9e-28 glucosamine--fructose-6-phosphate aminotransferase, putative K00820; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM0573. (353 aa) |
| | uspG | Universal stress family protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0614; ybdQ. (142 aa) |
| | citF | KEGG: sew:SeSA_A0780 9.5e-266 citF; citrate lyase, alpha subunit K01643; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0621; citF. (509 aa) |
| | EHY69533.1 | KEGG: see:SNSL254_A0676 1.0e-151 citE; citrate (pro-3S)-lyase, beta subunit K01644; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0622; citE; Belongs to the HpcH/HpaI aldolase family. (302 aa) |
| | citD | Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase. (98 aa) |
| | pagp | Antimicrobial peptide resistance and lipid A acylation protein PagP; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (187 aa) |
| | nadD | Nicotinate nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (216 aa) |
| | corC | Transporter associated domain protein; KEGG: eci:UTI89_C0656 1.5e-148 ybeX; putative transport protein K06189; Psort location: CytoplasmicMembrane, score: 7.88; locus tag in AE006468 is STM0667; ybeX. (292 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (347 aa) |
| | gpmA | Phosphoglycerate mutase 1 family protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | ywpJ | Cof-like hydrolase; KEGG: sew:SeSA_A0934 1.7e-147 phosphotransferase K07024; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0784; ybhA. (286 aa) |
| | pgl | Putative 6-phosphogluconolactonase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. (331 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa) |
| | moaB | Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (170 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa) |
| | moaD | Molybdopterin converting factor, subunit 1; Locus tag in AE006468 is STM0805; moaD. (81 aa) |
| | EHY69703.1 | Molybdopterin converting factor, subunit 2; Locus tag in AE006468 is STM0806; moaE. (150 aa) |
| | clsB | Phospholipase D domain protein; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (413 aa) |
| | moeB | KEGG: eci:UTI89_C0829 1.4e-115 moeB; molybdopterin biosynthesis protein MoeB K03751; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0845; moeB. (249 aa) |
| | EHY69743.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (411 aa) |
| | grxA | Glutaredoxin, GrxA family; KEGG: tcx:Tcr_0139 1.4e-07 glutaredoxin-like region; K03386 peroxiredoxin (alkyl hydroperoxide reductase subunit C); Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0872; grxA. (87 aa) |
| | cmk | Cytidylate kinase; KEGG: spq:SPAB_02536 1.6e-112 cmk; cytidylate kinase; K00945 cytidylate kinase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0980; cmk. (227 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (325 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (400 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa) |
| | clsC | Phospholipase D domain protein; Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE); Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily. (434 aa) |
| | lpxL | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa) |
| | pyrC | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) |
| | EHY70021.1 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (194 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (349 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) |
| | thiK | Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (273 aa) |
| | EHY70073.1 | Adenylosuccinate lyase; KEGG: stm:STM1232 5.2e-242 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1232; purB. (456 aa) |
| | EHY70161.1 | Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: sek:SSPA1445 3.4e-174 glyceraldehyde 3-phosphate dehydrogenase A; K00134 glyceraldehyde 3-phosphate dehydrogenase; Psort location: Cytoplasmic, score: 10.00; locus tag in AE006468 is STM1290; gapA; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | EHY70164.1 | Isochorismatase family protein; KEGG: seh:SeHA_C1420 2.8e-115 nicotinamidase/pyrazinamidase; K01440 nicotinamidase K08281; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM1293; pncA. (218 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (275 aa) |
| | pykF | Pyruvate kinase; KEGG: sei:SPC_2351 8.4e-242 pykF; pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1378; pykF. (470 aa) |
| | EHY70277.1 | KEGG: ses:SARI_01567 1.0e-220 type III secretion system ATPase; K03224 ATP synthase in type III secretion protein SctN; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1415; ssaN. (433 aa) |
| | purR | Periplasmic binding protein and sugar binding domain of the LacI family protein; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (341 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | pdxY | Pyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (286 aa) |
| | add | Adenosine deaminase; KEGG: seh:SeHA_C1633 8.2e-173 add; adenosine deaminase K01488; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1463; add; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa) |
| | ygaD_2 | Competence/damage-inducible protein CinA protein; KEGG: rsp:RSP_1822 6.6e-11 NH(3)-dependent NAD(+) synthetase K03743; locus tag in AE006468 is STM1514; ydeJ; Belongs to the CinA family. (175 aa) |
| | EHY70483.1 | KEGG: bxe:Bxe_B2247 3.5e-05 putative hexapeptide transferase family protein K00640; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1610; ydcK. (326 aa) |
| | EHY70533.1 | Hypothetical protein; KEGG: noc:Noc_1727 6.4e-05 phospholipid/glycerol acyltransferase K00655. (43 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa) |
| | EHY70629.1 | PAP2 family protein; KEGG: seh:SeHA_C1897 2.9e-138 phosphatidylglycerophosphatase B K01096; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM1710; pgpB. (254 aa) |
| | yciA | Thioesterase family protein; KEGG: stt:t1648 7.6e-67 yciA; acyl-CoA thioester hydrolase; K10806 acyl-CoA thioesterase YciA; locus tag in AE006468 is STM1736; yciA. (133 aa) |
| | cls | Cardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (486 aa) |
| | tdk | Thymidine kinase; KEGG: see:SNSL254_A1877 2.3e-104 tdk; thymidine kinase K00857; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM1750; tdk. (205 aa) |
| | rssA | Phospholipase, patatin family; KEGG: pct:PC1_1978 4.5e-101 lysophospholipase K07001; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1754; ychK. (301 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (280 aa) |
| | ipk | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (283 aa) |
| | prs | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | EHY70771.1 | Hydrolase, NUDIX family; KEGG: gbe:GbCGDNIH1_1634 8.1e-31 CoA pyrophosphatase; Psort location: CytoplasmicMembrane, score: 9.82; locus tag in AE006468 is STM1825; yeaB; Belongs to the Nudix hydrolase family. PCD1 subfamily. (192 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa) |
| | zwf | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa) |
| | pyk | Pyruvate kinase; Locus tag in AE006468 is STM1888; pykA; Belongs to the pyruvate kinase family. (480 aa) |
| | msbB | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (182 aa) |
| | fliI | Flagellar protein export ATPase FliI; KEGG: sed:SeD_A1270 1.0e-238 fliI; flagellum-specific ATP synthase K02412; Psort location: Cytoplasmic, score: 9.12; locus tag in AE006468 is STM1972; fliI. (456 aa) |
| | EHY71060.1 | Molybdenum cofactor synthesis domain protein; KEGG: psp:PSPPH_2159 2.0e-105 isocitrate/isopropylmalate family dehydrogenase K00052; Psort location: Cytoplasmic, score: 9.97. (725 aa) |
| | EHY71101.1 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa) |
| | udk | Uridine kinase; KEGG: sed:SeD_A2463 2.2e-108 udk; uridine kinase K00876; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2122; udk. (213 aa) |
| | yegS | Lipid kinase YegS; Probably phosphorylates lipids; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. (299 aa) |
| | fbaB | Deoxyribose-phosphate aldolase; KEGG: spt:SPA0711 1.1e-184 fbaB; fructose-bisphosphate aldolase K01623; locus tag in AE006468 is STM2141; fbaB. (350 aa) |
| | thiD | KEGG: sec:SC2161 9.7e-138 thiD; phosphomethylpyrimidine kinase; K00877 hydroxymethylpyrimidine kinase K00941; locus tag in AE006468 is STM2146; thiD. (266 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa) |
| | gtdA | KEGG: sew:SeSA_A2417 4.4e-190 gtdA; gentisate 1,2-dioxygenase K00450; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2178. (345 aa) |
| | folE | GTP cyclohydrolase I; KEGG: seg:SG2230 8.9e-112 folE; GTP cyclohydrolase I K01495; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2193; folE. (222 aa) |
| | yeiU | PAP2 family protein; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (237 aa) |
| | EHY71294.1 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (179 aa) |
| | napA | Periplasmic nitrate reductase, large subunit; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa) |
| | nrdB | KEGG: ses:SARI_00614 5.3e-201 nrdB; ribonucleotide-diphosphate reductase subunit beta; K00526 ribonucleoside-diphosphate reductase beta chain; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2278; nrdB. (376 aa) |
| | EHY71351.1 | KEGG: sew:SeSA_A2512 7.3e-291 glpA; sn-glycerol-3-phosphate dehydrogenase subunit A K00111; Psort location: Cytoplasmic, score: 9.12; locus tag in AE006468 is STM2284; glpA; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa) |
| | glpB | Glycerol-3-phosphate dehydrogenase [NAD(P)+ ] B subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. (419 aa) |
| | cinA | Competence/damage-inducible protein CinA protein; KEGG: dre:445492 2.3e-09 flad1; FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) K00953; locus tag in AE006468 is STM2293; Belongs to the CinA family. (398 aa) |
| | arnB | DegT/DnrJ/EryC1/StrS aminotransferase family protein; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (385 aa) |
| | arnC | Glycosyltransferase, group 2 family protein; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (327 aa) |
| | arnA | UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (660 aa) |
| | arnD | Polysaccharide deacetylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (299 aa) |
| | arnT | Dolichyl-phosphate-mannose-protein mannosyltransferase; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (548 aa) |
| | arnE | Multidrug resistance protein, SMR family; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (111 aa) |
| | arnF | Hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (125 aa) |
| | yfbR | HD domain protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | EHY71403.1 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa) |
| | yfcD | KEGG: ecf:ECH74115_3439 2.4e-86 hydrolase, NUDIX family protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2346. (184 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (304 aa) |
| | lpxP | Cold shock-induced palmitoleoyl transferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa) |
| | glk | Glucokinase; KEGG: sec:SC2406 1.5e-171 glk; glucokinase K00845; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2403; glk; Belongs to the bacterial glucokinase family. (321 aa) |
| | pdxK | Pyridoxal kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. (287 aa) |
| | tal-2 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (666 aa) |
| | nudK | Nudix hydrolase, YffH family; KEGG: eic:NT01EI_1232 7.9e-56 putative hydrolase YffH; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2477; yffH. (200 aa) |
| | purC | KEGG: seg:SG2517 2.5e-123 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2487; purC; Belongs to the SAICAR synthetase family. (237 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: stm:STM2499.S 7.5e-186 purM; phosphoribosylaminoimidazole synthetase K01933; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2499; purM. (350 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa) |
| | ppk1 | Polyphosphate kinase 1; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (688 aa) |
| | guaA | GMP synthase protein; Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | imdH | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (372 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | suhB | KEGG: seh:SeHA_C2808 1.5e-139 suhB; inositol monophosphatase K01092; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2546; suhB. (267 aa) |
| | asrB | KEGG: set:SEN2529 5.0e-141 asrB; anaerobic sulfite reductase subunit B; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2549; asrB. (259 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa) |
| | yfhb | HAD superfamily hydrolase, YfhB; KEGG: ccs:CCNA_02001 9.6e-12 phosphoserine phosphatase; Psort location: CytoplasmicMembrane, score: 9.82; locus tag in AE006468 is STM2569; yfhB. (211 aa) |
| | EHY71661.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (540 aa) |
| | EHY71671.1 | Phospholipase D domain protein; KEGG: sty:STY2845 5.0e-244 pssA; phosphatidylserine synthase K00998; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2652; pssA. (451 aa) |
| | ppnK | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa) |
| | EHY68384.1 | Competence/damage-inducible protein CinA protein; KEGG: cco:CCC13826_0279 3.8e-24 fadD; long-chain-fatty-acid--CoA ligase K03743; locus tag in AE006468 is STM2830; ygaD; Belongs to the CinA family. (166 aa) |
| | SBOV28861 | Hypothetical protein; Locus tag in AE006468 is STM2860; ygbA. (114 aa) |
| | EHY68450.1 | Invasion protein InvC; Locus tag in AE006468 is STM2894; invC. (431 aa) |
| | surE | 5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (250 aa) |
| | ygbB | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (183 aa) |
| | EHY68481.1 | Hypothetical protein; KEGG: stm:STM2930 1.8e-24 ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991; locus tag in AE006468 is STM2930; ispD. (56 aa) |
| | EHY68511.1 | Hypothetical protein; KEGG: sbo:SBO_2660 4.3e-32 eno; phosphopyruvate hydratase K01689; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM2952; eno. (75 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | mazG | MazG family protein; KEGG: sea:SeAg_B3087 2.7e-133 mazG; nucleoside triphosphate pyrophosphohydrolase; K02428 nucleoside-triphosphate pyrophosphatase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2954; mazG. (263 aa) |
| | EHY68519.1 | GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | aas | Acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. (719 aa) |
| | idi | Isopentenyl-diphosphate delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (181 aa) |
| | rpiA | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa) |
| | scpC_2 | Succinate CoA transferase; KEGG: eum:ECUMN_3264 1.5e-235 ygfH; propionyl-CoA:succinate-CoA transferase. (492 aa) |
| | fba | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | pgk | Phosphoglycerate kinase; KEGG: seh:SeHA_C3306 3.5e-197 pgk; phosphoglycerate kinase K00927; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3069; pgk. (387 aa) |
| | gapA | D-erythrose-4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (342 aa) |
| | EHY68645.1 | KEGG: efe:EFER_2517 1.7e-197 glycerol kinase 2 (ATP:glycerol 3-phosphotransferase 2) (glycerokinase 2) (GK 2) K00864; Psort location: Cytoplasmic, score: 9.26. (502 aa) |
| | tkt-2 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa) |
| | yqgE | Hypothetical protein; Locus tag in AE006468 is STM3096; yqgE; Belongs to the UPF0301 (AlgH) family. (196 aa) |
| | rdgB | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa) |
| | hit | Hypothetical protein; Locus tag in AE006468 is STM3167. (114 aa) |
| | plsC | Acyltransferase; KEGG: seh:SeHA_C3423 2.9e-129 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM3173; plsC. (245 aa) |
| | nudF | Nudix hydrolase, YffH family; KEGG: sed:SeD_A3538 4.7e-106 nudF; ADP-ribose pyrophosphatase NudF; K01515 ADP-ribose pyrophosphatase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3185; yqiE. (210 aa) |
| | plsY | Acyl-phosphate glycerol 3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl- PO(4); Belongs to the PlsY family. (205 aa) |
| | EHY68821.1 | Hypothetical protein; KEGG: rrj:RrIowa_0485 0.0038 zinc metalloprotease K07043; locus tag in AE006468 is STM3221; ygjP. (165 aa) |
| | kbaZ | D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit; Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of KbaY. When expressed alone, KbaZ does not show any aldolase activity. (435 aa) |
| | kbaY | Class II aldolase, tagatose bisphosphate family protein; KEGG: ses:SARI_04361 1.6e-144 kbaY; tagatose-bisphosphate aldolase; K08302 tagatose 1,6-diphosphate aldolase; Psort location: Cytoplasmic, score: 8.96. (290 aa) |
| | yhdE | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | nudE | Hydrolase, NUDIX family; KEGG: seh:SeHA_C3800 7.2e-94 nudE; ADP-ribose diphosphatase NudE K08312; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3494; yrfE. (187 aa) |
| | EHY67857.1 | KEGG: ses:SARI_04095 1.9e-269 glpD; glycerol-3-phosphate dehydrogenase; K00111 glycerol-3-phosphate dehydrogenase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3526; glpD; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (502 aa) |
| | eptB | Arylsulfatase; KEGG: see:SNSL254_A3913 6.3e-301 membrane-associated sulfatase; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM3635; yhjW. (563 aa) |
| | gpsA | KEGG: seh:SeHA_C4025 3.7e-177 gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; K00057 glycerol-3-phosphate dehydrogenase (NAD(P)+); Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3700; gpsA; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa) |
| | grxC | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. (83 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | coaBC | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (407 aa) |
| | dut | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | spoT | Guanosine 3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (703 aa) |
| | glmU | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (460 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (177 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (79 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (271 aa) |
| | gppA | Ppx/GppA phosphatase family protein; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (499 aa) |
| | cyaA | KEGG: ses:SARI_03713 0. cyaA; adenylate cyclase; K05851 adenylate cyclase, class 1; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3939; cyaA; Belongs to the adenylyl cyclase class-1 family. (848 aa) |
| | EHY68277.1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa) |
| | EHY67580.1 | Molybdopterin-guanine dinucleotide biosynthesis protein B; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3993; mobB. (172 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (194 aa) |
| | EHY67601.1 | N-acylglucosamine 2-epimerase; Catalyzes the isomerization of sulfoquinovose (SQ) to 6- deoxy-6-sulfo-D-fructose (SF). (413 aa) |
| | EHY67619.1 | Tat pathway signal sequence; KEGG: stm:STM4037 1.5e-102 fdoG; formate dehydrogenase alpha subunit K00123; Psort location: Periplasmic, score: 9.76; locus tag in AE006468 is STM4037; fdoG. (195 aa) |
| | fdhD | Accessory protein FdhD, formate dehydrogenase family; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (236 aa) |
| | EHY67628.1 | Hypothetical protein. (208 aa) |
| | EHY67635.1 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (326 aa) |
| | EHY67638.1 | Putative fructose-1,6-bisphosphate aldolase; KEGG: kpe:KPK_5486 4.5e-133 fructose-bisphosphate aldolase, class II family; K01624 fructose-bisphosphate aldolase, class II; Psort location: Cytoplasmic, score: 8.96. (280 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | cdh | KEGG: ses:SARI_03579 6.7e-130 CDP-diacylglycerol pyrophosphatase; K01521 CDP-diacylglycerol pyrophosphatase; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM4064; ushB. (249 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (502 aa) |
| | EHY67717.1 | 5'-nucleotidase protein; KEGG: efe:EFER_3829 1.7e-259 putative phosphoesterase; Psort location: Periplasmic, score: 9.44; locus tag in AE006468 is STM4104; Belongs to the 5'-nucleotidase family. (518 aa) |
| | coaA | Pantothenate kinase; Locus tag in AE006468 is STM4139; coaA. (318 aa) |
| | thiG | Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | thiS | Thiamine biosynthesis protein ThiS; Locus tag in AE006468 is STM4161. (66 aa) |
| | EHY67135.1 | Putative thiazole biosynthesis adenylyltransferase ThiF; Locus tag in AE006468 is STM4162; thiF. (252 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa) |
| | nudC | NAD(+) diphosphatase; Locus tag in AE006468 is STM4166; yjaD; Belongs to the Nudix hydrolase family. NudC subfamily. (257 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Locus tag in AE006468 is STM4175; purD. (429 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Locus tag in AE006468 is STM4176; purH. (529 aa) |
| | pgi | Glucose-6-phosphate isomerase; Locus tag in AE006468 is STM4221; pgi; Belongs to the GPI family. (549 aa) |
| | plsB | KEGG: stt:t4141 0. plsB; glycerol-3-phosphate acyltransferase K00631; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM4235; plsB; Belongs to the GPAT/DAPAT family. (806 aa) |
| | dgkA | Prokaryotic diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (122 aa) |
| | acs | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa) |
| | EHY67246.1 | Acetyltransferase, GNAT family; Locus tag in AE006468 is STM4287; phnO. (144 aa) |
| | yjdN | Protein PhnB; Locus tag in AE006468 is STM4288; phnB. (147 aa) |
| | eptA | Arylsulfatase; Locus tag in AE006468 is STM4293; yjdB. (547 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (322 aa) |
| | nnrE | YjeF protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of [...] (514 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | cpdB | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Locus tag in AE006468 is STM4403; cpdB; Belongs to the 5'-nucleotidase family. (647 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (230 aa) |
| | nrdG | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa) |
| | pyrB | Aspartate carbamoyltransferase; Locus tag in AE006468 is STM4460; pyrB; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa) |
| | glmS_2 | SIS domain protein; Locus tag in AE006468 is STM4539. (353 aa) |
| | EHY67525.1 | SIS domain protein; Locus tag in AE006468 is STM4540. (336 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (271 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa) |
| | nadR | Nicotinamide-nucleotide adenylyltransferase; Locus tag in AE006468 is STM4580; nadR. (410 aa) |
| | yjjX | Hypothetical protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (171 aa) |
| | gpmB | Phosphoglycerate mutase family protein; Locus tag in AE006468 is STM4585; gpmB; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |
