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| | thrA | Homoserine dehydrogenase; KEGG: set:SEN0001 0. thrA; bifunctional aspartokinase I/homeserine dehydrogenase I; K12524 bifunctional aspartokinase/homoserine dehydrogenase 1; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0002; thrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa) |
| | EHY68979.1 | Threonine synthase; KEGG: sed:SeD_A0004 1.2e-224 thrC; threonine synthase K01733; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0004; thrC. (428 aa) |
| | EHY69015.1 | KEGG: sei:SPC_0047 2.9e-152 ribF; hypothetical protein; K11753 riboflavin kinase / FMN adenylyltransferase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0045; ribF. (295 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | carA | KEGG: see:SNSL254_A0070 5.5e-199 carA; carbamoyl-phosphate synthase, small subunit K01956; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0066; carA; Belongs to the CarA family. (382 aa) |
| | carB | KEGG: ses:SARI_02937 0. carB; carbamoyl phosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; locus tag in AE006468 is STM0067; carB; Belongs to the CarB family. (1074 aa) |
| | EHY69046.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (159 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (523 aa) |
| | EHY69078.1 | KEGG: spq:SPAB_00147 1.0e-300 acetolactate synthase 3 catalytic subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: CytoplasmicMembrane, score: 8.46; locus tag in AE006468 is STM0116; ilvI. (566 aa) |
| | EHY69079.1 | KEGG: see:SNSL254_A0129 7.2e-78 ilvH; acetolactate synthase, small subunit, isozyme III K01653; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0117; ilvH. (164 aa) |
| | EHY69143.1 | KEGG: spq:SPAB_00209 2.4e-93 hypoxanthine-guanine phosphoribosyltransferase; K00760 hypoxanthine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0170; hpt; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (198 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (263 aa) |
| | folK | KEGG: ses:SARI_02814 2.6e-73 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; K00950 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; locus tag in AE006468 is STM0183; folK. (159 aa) |
| | mtnN | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...] (232 aa) |
| | dapD | KEGG: sed:SeD_A0234 5.6e-142 dapD; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase K00674; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0213; dapD; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (151 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | EHY69239.1 | Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.82. (361 aa) |
| | EHY69243.1 | Hypothetical protein; KEGG: pag:PLES_00991 1.4e-10 3-oxoacyl-(acyl carrier protein) synthase; K00647 3-oxoacyl-[acyl-carrier-protein] synthase I. (345 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | aroL | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (181 aa) |
| | aroM | AroM protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0390; aroM. (225 aa) |
| | acpH | (acyl-carrier-protein) phosphodiesterase; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family. (193 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (354 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (375 aa) |
| | EHY69347.1 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (156 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | apbA | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (272 aa) |
| | ybaX | ExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa) |
| | cof | Cof-like hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). (276 aa) |
| | EHY69381.1 | Pyridoxal-phosphate dependent enzyme; KEGG: set:SEN0440 3.4e-190 putative lyase; K01738 cysteine synthase A; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0458. (351 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | EHY69468.1 | Alginate O-acetyltransferase AlgI family protein; KEGG: cbk:CLL_A3010 7.8e-81 putative poly(beta-D-mannuronate) O-acetylase; Psort location: CytoplasmicMembrane, score: 10.00. (486 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | ubiF | KEGG: sed:SeD_A0777 1.0e-206 ubiF; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase K03184; locus tag in AE006468 is STM0671; ubiF. (391 aa) |
| | asnB | Asparagine synthase; KEGG: spq:SPAB_02863 1.1e-301 asnB; asparagine synthetase B; K01953 asparagine synthase (glutamine-hydrolysing); Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0680; asnB. (554 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (347 aa) |
| | aroG | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (393 aa) |
| | gpmA | Phosphoglycerate mutase 1 family protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | EHY69662.1 | Putative 3-ketoacyl-(acyl-carrier-protein) reductase; KEGG: shl:Shal_2747 1.2e-86 short-chain dehydrogenase/reductase SDR; K00059 3-oxoacyl-[acyl-carrier protein] reductase; Psort location: Cytoplasmic, score: 9.26. (241 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (429 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (346 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa) |
| | bioC | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (228 aa) |
| | EHY69716.1 | Glycosyl transferase family, helical bundle domain protein; KEGG: mms:mma_0486 6.3e-63 trpD2; glycosyl transferase family protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0822; ybiB. (324 aa) |
| | supH | Cof-like hydrolase; KEGG: stm:STM0842 1.1e-138 ybiV(1); putative hydrolase; K07757 sugar-phosphatase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0842; ybiV(1). (269 aa) |
| | EHY69768.1 | Cof-like hydrolase; KEGG: sed:SeD_A0971 2.8e-140 phosphatase YbjI K07024; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0867. (271 aa) |
| | EHY69809.1 | NAD dependent epimerase/dehydratase family protein; KEGG: hma:rrnAC2178 3.6e-37 rfbB3; dTDP-glucose-46-dehydratase K01710; locus tag in AE006468 is STM0933; ybjT. (477 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | serC | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (399 aa) |
| | fabA | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (172 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (152 aa) |
| | putA | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1320 aa) |
| | ghrA | 4-phosphoerythronate dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa) |
| | lpxL | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (349 aa) |
| | fabH | 3-oxoacyl-(acyl carrier protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (317 aa) |
| | fabD | KEGG: spq:SPAB_02329 3.8e-159 acyl carrier protein S-malonyltransferase; K00645 [acyl-carrier-protein] S-malonyltransferase; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM1194; fabD. (309 aa) |
| | fabG_3 | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | EHY70030.1 | Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | pabC | Aminodeoxychorismate lyase; KEGG: sew:SeSA_A1274 1.0e-110 pabC; 4-amino-4-deoxychorismate lyase K02619; locus tag in AE006468 is STM1198; pabC. (269 aa) |
| | thiK | Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (273 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (347 aa) |
| | gdhA_2 | Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: seh:SeHA_C1426 6.8e-240 gdhA; glutamate dehydrogenase; K00262 glutamate dehydrogenase (NADP+); Psort location: OuterMembrane, score: 9.92; locus tag in AE006468 is STM1299; gdhA; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | astC | N-succinyldiaminopimelate- aminotransferase/acetylornithine transaminase protein; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily. (392 aa) |
| | aroH | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (233 aa) |
| | ydiB | Quinate/shikimate dehydrogenase; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. (288 aa) |
| | ydiI | Hypothetical protein; Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA). (136 aa) |
| | EHY70286.1 | KEGG: spq:SPAB_01898 6.5e-109 riboflavin synthase subunit alpha; K00793 riboflavin synthase alpha chain; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1426; ribE. (213 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | pdxY | Pyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (286 aa) |
| | ydgC | GlpM protein; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM1476; ydgC. (111 aa) |
| | bioD-2 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (248 aa) |
| | ydfG | Oxidoreductase, short chain dehydrogenase/reductase family protein; KEGG: sed:SeD_A1826 6.1e-129 3-hydroxy acid dehydrogenase K00540; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1511; ydfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | EHY70419.1 | Putative S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (324 aa) |
| | EHY70577.1 | Putative organophosphate reductase; KEGG: eci:UTI89_C0323 1.7e-133 2,5-diketo-D-gluconic acid reductase A; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1676. (289 aa) |
| | EHY70589.1 | Hypothetical protein; KEGG: eum:ECUMN_0336 8.9e-25 putative aldo-keto reductase. (70 aa) |
| | fabI | Oxidoreductase, short chain dehydrogenase/reductase family protein; KEGG: ses:SARI_01263 1.9e-134 enoyl-(acyl carrier protein) reductase; K00208 enoyl-[acyl-carrier protein] reductase I; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM1700; fabI. (262 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. (225 aa) |
| | cobO | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (196 aa) |
| | EHY70645.1 | KEGG: set:SEN1311 7.3e-275 trpE; anthranilate synthase component I; K01657 anthranilate synthase component I; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1723; trpE. (520 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa) |
| | trpF | KEGG: spq:SPAB_01520 6.2e-230 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; K01609 indole-3-glycerol phosphate synthase K01817; locus tag in AE006468 is STM1725; trpC; Belongs to the TrpC family. (452 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | kdsA | 3-deoxy-8-phosphooctulonate synthase; KEGG: ses:SARI_01181 1.1e-147 2-dehydro-3-deoxyphosphooctonate aldolase; K01627 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase); Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1772; kdsA; Belongs to the KdsA family. (284 aa) |
| | EHY70772.1 | L-serine ammonia-lyase; KEGG: spq:SPAB_01388 7.4e-243 hypothetical protein; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1826; sdaA. (454 aa) |
| | msbB | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa) |
| | ntpA | Hydrolase, NUDIX family; Locus tag in AE006468 is STM1900; ntpA. (127 aa) |
| | yedP | Mannosyl-3-phosphoglycerate phosphatase-like protein; KEGG: sty:STY2193 1.8e-145 mannosyl-3-phosphoglycerate phosphatase K07026; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1986; yedP. (271 aa) |
| | EHY71076.1 | Hypothetical protein; KEGG: sek:SSPA0797 1.4e-15 cobyric acid synthase; K02232 adenosylcobyric acid synthase. (53 aa) |
| | EHY71077.1 | Hypothetical protein; KEGG: stm:STM2019 3.8e-49 cbiP; cobyric acid synthase; K02232 adenosylcobyric acid synthase. (108 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (289 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | hisC | KEGG: spq:SPAB_00960 1.2e-187 histidinol-phosphate aminotransferase; K00817 histidinol-phosphate aminotransferase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2073; hisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa) |
| | hisB | Histidinol-phosphatase; KEGG: sea:SeAg_B2199 2.4e-189 hisB; imidazole glycerol-phosphate dehydratase/histidinol phosphatase K01089; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2074; hisB; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisA | KEGG: see:SNSL254_A2255 7.9e-120 hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2076; hisA. (245 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisI | phosphoribosyl-ATP diphosphatase; KEGG: sew:SeSA_A2306 7.9e-104 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein K11755; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2078; hisI; In the N-terminal section; belongs to the PRA-CH family. (203 aa) |
| | EHY71100.1 | Nucleotide sugar dehydrogenase; KEGG: seg:SG2110 1.3e-199 udg; UDP-glucose 6-dehydrogenase K00012; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2080; udg. (388 aa) |
| | EHY71106.1 | KEGG: gur:Gura_1692 2.6e-82 imidazole glycerol phosphate synthase subunit HisF; K02500 cyclase HisF; Psort location: Cytoplasmic, score: 9.26. (262 aa) |
| | EHY71107.1 | KEGG: vvy:VV0355 1.5e-61 hisH; imidazole glycerol phosphate synthase subunit HisH; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 9.26. (204 aa) |
| | wcaB | Bacterial transferase hexapeptide repeat protein; KEGG: spq:SPAB_00916 4.0e-84 putative colanic acid biosynthesis acetyltransferase WcaB; K03819 putative colanic acid biosynthesis acetyltransferase WcaB; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM2114; wcaB; Belongs to the transferase hexapeptide repeat family. (162 aa) |
| | thiD | KEGG: sec:SC2161 9.7e-138 thiD; phosphomethylpyrimidine kinase; K00877 hydroxymethylpyrimidine kinase K00941; locus tag in AE006468 is STM2146; thiD. (266 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa) |
| | gtdA | KEGG: sew:SeSA_A2417 4.4e-190 gtdA; gentisate 1,2-dioxygenase K00450; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2178. (345 aa) |
| | ubiG | 3-demethylubiquinone-9 3-O-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (242 aa) |
| | EHY71368.1 | O-succinylbenzoate-CoA ligase; KEGG: see:SNSL254_A2490 1.1e-239 menE; O-succinylbenzoate-CoA ligase K01911; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2305; menE. (455 aa) |
| | menC | O-succinylbenzoic acid synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (320 aa) |
| | menB | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (285 aa) |
| | menH | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). (252 aa) |
| | menD | 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (556 aa) |
| | menF | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. (431 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (189 aa) |
| | EHY71427.1 | KEGG: sty:STY2590 5.5e-254 putative amino acid decarboxylase; K01586 diaminopimelate decarboxylase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2360. (465 aa) |
| | EHY71433.1 | Protein FolC; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. (422 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (304 aa) |
| | EHY71437.1 | Semialdehyde dehydrogenase, dimerization domain protein; KEGG: see:SNSL254_A2557 2.7e-174 aspartate-semialdehyde dehydrogenase family protein; K00133 aspartate-semialdehyde dehydrogenase; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM2369; usg. (337 aa) |
| | pdxB | Putative erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa) |
| | fabB | KEGG: ses:SARI_00522 2.0e-210 3-oxoacyl-(acyl carrier protein) synthase I; K00647 3-oxoacyl-[acyl-carrier-protein] synthase I; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2378; fabB; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | lpxP | Cold shock-induced palmitoleoyl transferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa) |
| | cysZ | Putative sulfate transport protein CysZ; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (253 aa) |
| | cysK | Cysteine synthase A; KEGG: see:SNSL254_A2623 1.7e-165 cysK; cysteine synthase A K01738; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2430; cysK; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | pdxK | Pyridoxal kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. (287 aa) |
| | cysM | Cysteine synthase B; KEGG: sea:SeAg_B2585 1.3e-151 cysM; cysteine synthase B K12339; locus tag in AE006468 is STM2440; cysM; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | EHY71544.1 | cob(I)yrinic acid a,c-diamide adenosyltransferase; KEGG: sea:SeAg_B2612 6.3e-134 eutT; ethanolamine utilization cobalamin adenosyltransferase K04032; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2467; eutT. (267 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | purC | KEGG: seg:SG2517 2.5e-123 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2487; purC; Belongs to the SAICAR synthetase family. (237 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | acpS | Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa) |
| | pheA | Chorismate mutase; KEGG: seg:SG2645 1.3e-199 pheA; bifunctional chorismate mutase/prephenate dehydratase; K04093 chorismate mutase K04518; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2667; pheA. (386 aa) |
| | EHY68302.1 | SMP-30/Gluconolaconase/LRE-like region; KEGG: ent:Ent638_3078 7.1e-135 gluconolactonase K01053; locus tag in AE006468 is STM2668. (302 aa) |
| | tyrA | Chorismate mutase; KEGG: spq:SPAB_03380 6.0e-193 tyrA; bifunctional chorismate mutase/prephenate dehydrogenase; K04092 chorismate mutase K04517; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2669; tyrA. (373 aa) |
| | EHY68304.1 | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa) |
| | EHY68320.1 | Polyketide cyclase/dehydrase; Locus tag in AE006468 is STM2687; yfjG. (93 aa) |
| | gutQ | Putative arabinose 5-phosphate isomerase; Locus tag in AE006468 is STM2838; gutQ. (321 aa) |
| | iacP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (95 aa) |
| | cysI | Sulfite reductase hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa) |
| | cysJ | Sulfite reductase [NADPH] flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. (599 aa) |
| | queD | 6-pyruvoyl tetrahydropterin synthase/QueD family protein; KEGG: sty:STY3077 2.5e-43 putative 6-pyruvoyl tetrahydrobiopterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase; locus tag in AE006468 is STM2949; ptpS. (86 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (232 aa) |
| | queF | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (282 aa) |
| | sdaB | KEGG: see:SNSL254_A3194 1.2e-240 L-serine ammonia-lyase K01752; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2971; sdaB; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) |
| | argA | Amino-acid N-acetyltransferase; KEGG: stt:t2900 2.1e-229 argA; N-acetylglutamate synthase K00619; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2992; argA; Belongs to the acetyltransferase family. ArgA subfamily. (443 aa) |
| | lysA_1 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | ubiF_1 | 2-octaprenyl-6-methoxyphenol hydroxylase; KEGG: see:SNSL254_A3292 2.7e-213 protein VisC; locus tag in AE006468 is STM3056; visC. (400 aa) |
| | EHY68614.1 | 2-polyprenyl-6-methoxyphenol 4-hydroxylase; KEGG: sty:STY3213 8.1e-205 visB; 2-octaprenyl-6-methoxyphenyl hydroxylase K03185; locus tag in AE006468 is STM3057; ubiH. (392 aa) |
| | serA | KEGG: spq:SPAB_03816 2.1e-213 D-3-phosphoglycerate dehydrogenase; K00058 D-3-phosphoglycerate dehydrogenase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3062; serA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa) |
| | gapA | D-erythrose-4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (342 aa) |
| | dkgA | Oxidoreductase, aldo/keto reductase family protein; KEGG: stm:STM3165 9.5e-147 dkgA; 2,5-diketo-D-gluconate reductase A K06221; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3165; yqhE. (275 aa) |
| | ribB | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (217 aa) |
| | EHY68791.1 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3196; yqiC. (98 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa) |
| | tdcG | KEGG: sek:SSPA2901 4.0e-235 L-serine dehydratase; K01752 L-serine dehydratase; locus tag in AE006468 is STM3240; tdcG; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | EHY68867.1 | SCP-2 sterol transfer family protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3273; yhbT. (174 aa) |
| | EHY68868.1 | Peptidase, U32 family; KEGG: sei:SPC_3345 1.4e-177 yhbU; putative protease; K08303 putative protease; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3274; yhbU. (331 aa) |
| | EHY68869.1 | Peptidase, U32 family; KEGG: ecm:EcSMS35_3455 1.1e-145 peptidase, U32 family; locus tag in AE006468 is STM3275; yhbV. (292 aa) |
| | argG | KEGG: ses:SARI_04334 4.0e-235 argininosuccinate synthase; K01940 argininosuccinate synthase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3290; argG; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa) |
| | EHY68884.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa) |
| | EHY68918.1 | Class II glutamine amidotransferase; KEGG: stt:t3247 0. gltB; glutamate synthase subunit alpha K00265; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3330; gltB. (1486 aa) |
| | EHY68919.1 | KEGG: spq:SPAB_04154 4.9e-253 gltD; glutamate synthase subunit beta; K00266 glutamate synthase (NADPH/NADH) small chain; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3331; gltD. (472 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (156 aa) |
| | accB | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | EHY67798.1 | Hydrolase, alpha/beta fold family protein; KEGG: dre:393888 1.4e-16 abhd2a; abhydrolase domain containing 2a K01066; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3462; yheT. (340 aa) |
| | argD | N-succinyldiaminopimelate- aminotransferase/acetylornithine transaminase protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | cobA | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (457 aa) |
| | EHY67818.1 | Phosphoglycolate phosphatase, bacterial; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (252 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (342 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (161 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (539 aa) |
| | bioH | Putative pimeloyl-BioC--CoA transferase BioH; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (256 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa) |
| | panM | Acetyltransferase, GNAT family; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion; Belongs to the PanZ/PanM family. (127 aa) |
| | yhhQ | Conserved hypothetical integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (221 aa) |
| | EHY68003.1 | KEGG: sec:SC3622 1.1e-143 cysE; serine acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3699; cysE; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | ilvN | KEGG: ses:SARI_03854 2.7e-46 acetolactate synthase 1 regulatory subunit; K01653 acetolactate synthase I/III small subunit; locus tag in AE006468 is STM3795; ilvN. (96 aa) |
| | ilvB | KEGG: sei:SPC_3877 5.4e-295 ilvB; acetolactate synthase large subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3796; ilvB. (562 aa) |
| | asnA | Aspartate--ammonia ligase; KEGG: spq:SPAB_04821 5.4e-176 asparagine synthetase AsnA; K01914 aspartate--ammonia ligase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3877; asnA. (330 aa) |
| | EHY68204.1 | KEGG: ses:SARI_03751 1.0e-284 acetolactate synthase 2 catalytic subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3901; ilvG. (548 aa) |
| | ilvM | KEGG: sed:SeD_A4292 8.0e-40 ilvM; acetolactate synthase 2 regulatory subunit K11258; locus tag in AE006468 is STM3902; ilvM. (87 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa) |
| | ilvD | KEGG: seh:SeHA_C4235 0. ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3904; ilvD; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvA | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | fabV | Short-chain alcohol dehydrogenase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (374 aa) |
| | ilvY | HTH-type transcriptional activator IlvY; KEGG: shn:Shewana3_3435 1.2e-15 LysR family transcriptional regulator; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3908; ilvY; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | EHY68246.1 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | yigB | HAD-superfamily hydrolase, subfamily IA, variant 1; KEGG: vcj:VCD_001589 1.2e-50 2-haloalkanoic acid dehalogenase K07025; locus tag in AE006468 is STM3950; yigB. (238 aa) |
| | yigL | Cof-like hydrolase; KEGG: bau:BUAPTUC7_028 1.7e-55 yigL; sugar phosphatase K07024; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3962; yigL. (266 aa) |
| | metR | KEGG: spl:Spea_0904 1.7e-15 LysR family transcriptional regulator; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3964; metR; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (251 aa) |
| | ubiJ | SCP-2 sterol transfer family protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3971; yigP. (201 aa) |
| | ubiB | 2-polyprenylphenol 6-hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (546 aa) |
| | ubiD | UbiD family decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (492 aa) |
| | glnA | KEGG: sec:SC3899 3.4e-254 glnA; glutamine synthetase K01915; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM4007; glnA. (469 aa) |
| | EHY67655.1 | KEGG: cko:CKO_03091 2.7e-44 hypothetical protein; K01714 dihydrodipicolinate synthase. (133 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | glpX | Fructose-1,6-bisphosphatase, class II; KEGG: stt:t3533 2.1e-167 glpX; fructose 1,6-bisphosphatase II K02446; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM4085; glpX. (325 aa) |
| | menA | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (313 aa) |
| | metJ | Met Apo-repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa) |
| | metL | Homoserine dehydrogenase; KEGG: sty:STY3768 0. metL, metM; bifunctional aspartate kinase II/homoserine dehydrogenase II K12525; Psort location: CytoplasmicMembrane, score: 9.82; locus tag in AE006468 is STM4101; metL; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) |
| | metF | KEGG: stt:t3511 5.8e-156 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM4105; metF. (296 aa) |
| | argE | KEGG: set:SEN3915 1.6e-208 argE; acetylornithine deacetylase; K01438 acetylornithine deacetylase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM4120; argE. (383 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa) |
| | argH | Argininosuccinate lyase; KEGG: spq:SPAB_05108 3.8e-239 argininosuccinate lyase; K01755 argininosuccinate lyase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM4123; argH. (457 aa) |
| | fabR | Transcriptional regulator, TetR family; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (211 aa) |
| | EHY67132.1 | Thiazole biosynthesis protein ThiH; Locus tag in AE006468 is STM4159; thiH. (377 aa) |
| | thiG | Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | thiS | Thiamine biosynthesis protein ThiS; Locus tag in AE006468 is STM4161. (66 aa) |
| | EHY67135.1 | Putative thiazole biosynthesis adenylyltransferase ThiF; Locus tag in AE006468 is STM4162; thiF. (252 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa) |
| | metAS | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa) |
| | EHY67160.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa) |
| | lysC | Aspartate kinase, monofunctional class; Locus tag in AE006468 is STM4220; lysC; Belongs to the aspartokinase family. (449 aa) |
| | pgi | Glucose-6-phosphate isomerase; Locus tag in AE006468 is STM4221; pgi; Belongs to the GPI family. (549 aa) |
| | ubiC | Chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. (165 aa) |
| | ubiA | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (290 aa) |
| | alr-2 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (359 aa) |
| | yjdN | Protein PhnB; Locus tag in AE006468 is STM4288; phnB. (147 aa) |
| | queG | Putative iron-sulfur cluster-binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (384 aa) |
| | EHY67336.1 | Putative beta-ketoacyl-acyl-carrier-protein synthase II. (416 aa) |
| | EHY67338.1 | Phosphopantetheine attachment site. (79 aa) |
| | EHY67339.1 | Putative 3-ketoacyl-(acyl-carrier-protein) reductase. (245 aa) |
| | fbp | Fructose-1,6-bisphosphatase; Locus tag in AE006468 is STM4415; fbp; Belongs to the FBPase class 1 family. (332 aa) |
| | ridA | Putative endoribonuclease L-PSP; Locus tag in AE006468 is STM4458; yjgF. (128 aa) |
| | argR_2 | Arginine repressor protein; Regulates arginine biosynthesis genes. (162 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa) |
| | argF-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa) |
| | EHY67430.1 | Acetyltransferase, GNAT family; Locus tag in AE006468 is STM4473; yjgM. (158 aa) |
| | EHY67433.1 | Hypothetical protein. (51 aa) |
| | EHY67434.1 | Hypothetical protein. (44 aa) |
| | serB | Phosphoserine phosphatase SerB; Locus tag in AE006468 is STM4578; serB. (294 aa) |
