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deoA deoA rihC rihC carA carA carB carB pyrH pyrH thiL thiL EHY69352.1 EHY69352.1 dxs dxs thiI thiI cof cof rihA rihA ycaC_3 ycaC_3 EHY69838.1 EHY69838.1 cmk cmk pyrD pyrD pyrC pyrC tmk tmk thiK thiK pyrF pyrF yecD yecD dcd dcd udk udk thiD thiD thiM thiM cdd cdd EHY71202.1 EHY71202.1 EHY71203.1 EHY71203.1 EHY71294.1 EHY71294.1 yfbR yfbR upp upp ndk ndk asrB asrB surE surE pyrG pyrG mazG mazG thyA thyA yqfB yqfB feaB feaB EHY68922.1 EHY68922.1 sgbH sgbH dut dut pyrE pyrE EHY68058.1 EHY68058.1 yigL yigL EHY68277.1 EHY68277.1 EHY67132.1 EHY67132.1 thiG thiG thiS thiS EHY67135.1 EHY67135.1 thiE thiE thiC thiC yjdN yjdN ulaD ulaD pyrI pyrI pyrB pyrB
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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deoAThymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (440 aa)
rihCInosine-uridine preferring nucleoside hydrolase; Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity. (304 aa)
carAKEGG: see:SNSL254_A0070 5.5e-199 carA; carbamoyl-phosphate synthase, small subunit K01956; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0066; carA; Belongs to the CarA family. (382 aa)
carBKEGG: ses:SARI_02937 0. carB; carbamoyl phosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; locus tag in AE006468 is STM0067; carB; Belongs to the CarB family. (1074 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa)
EHY69352.1Oxidoreductase, aldo/keto reductase family protein; KEGG: ecc:c0530 7.9e-159 yajO; oxidoreductase YajO; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0421; yajO. (324 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa)
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa)
cofCof-like hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). (276 aa)
rihAInosine-uridine preferring nucleoside hydrolase; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. (311 aa)
ycaC_3KEGG: kpe:KPK_3507 1.1e-104 isochorismatase hydrolase family protein; locus tag in AE006468 is STM0950. (225 aa)
EHY69838.1KEGG: ecm:EcSMS35_2223 1.5e-107 isochorismatase family protein. (208 aa)
cmkCytidylate kinase; KEGG: spq:SPAB_02536 1.6e-112 cmk; cytidylate kinase; K00945 cytidylate kinase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0980; cmk. (227 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
pyrCDihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa)
thiKThiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (273 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa)
yecDIsochorismatase family protein; Locus tag in AE006468 is STM1902; yecD. (188 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa)
udkUridine kinase; KEGG: sed:SeD_A2463 2.2e-108 udk; uridine kinase K00876; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2122; udk. (213 aa)
thiDKEGG: sec:SC2161 9.7e-138 thiD; phosphomethylpyrimidine kinase; K00877 hydroxymethylpyrimidine kinase K00941; locus tag in AE006468 is STM2146; thiD. (266 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
EHY71202.1Pyridine nucleotide-disulfide oxidoreductase; KEGG: eci:UTI89_C2419 4.7e-177 yeiT; putative oxidoreductase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2186. (413 aa)
EHY71203.1KEGG: sec:SC2204 2.0e-224 yeiA; dihydropyrimidine dehydrogenase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2187; yeiA. (411 aa)
EHY71294.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (179 aa)
yfbRHD domain protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
asrBKEGG: set:SEN2529 5.0e-141 asrB; anaerobic sulfite reductase subunit B; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2549; asrB. (259 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (250 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
mazGMazG family protein; KEGG: sea:SeAg_B3087 2.7e-133 mazG; nucleoside triphosphate pyrophosphohydrolase; K02428 nucleoside-triphosphate pyrophosphatase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2954; mazG. (263 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
yqfBASCH domain protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3050; yqfB; Belongs to the UPF0267 family. (103 aa)
feaBAldehyde dehydrogenase family protein; KEGG: ses:SARI_04502 2.3e-248 hypothetical protein; K00146 phenylacetaldehyde dehydrogenase; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3129. (494 aa)
EHY68922.1Cytosine deaminase; KEGG: sei:SPC_3404 1.6e-222 codA; cytosine deaminase; K01485 cytosine deaminase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3334. (426 aa)
sgbHOrotidine 5'-phosphate decarboxylase / HUMPS family protein; KEGG: set:SEN3497 6.9e-105 sgbH; 3-keto-L-gulonate-6-phosphate decarboxylase K03081; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3675; sgbH. (221 aa)
dutdUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
EHY68058.1KEGG: kpe:KPK_3507 2.1e-103 isochorismatase hydrolase family protein; locus tag in AE006468 is STM3761; slsA. (226 aa)
yigLCof-like hydrolase; KEGG: bau:BUAPTUC7_028 1.7e-55 yigL; sugar phosphatase K07024; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3962; yigL. (266 aa)
EHY68277.1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa)
EHY67132.1Thiazole biosynthesis protein ThiH; Locus tag in AE006468 is STM4159; thiH. (377 aa)
thiGThiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
thiSThiamine biosynthesis protein ThiS; Locus tag in AE006468 is STM4161. (66 aa)
EHY67135.1Putative thiazole biosynthesis adenylyltransferase ThiF; Locus tag in AE006468 is STM4162; thiF. (252 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa)
yjdNProtein PhnB; Locus tag in AE006468 is STM4288; phnB. (147 aa)
ulaDOrotidine 5'-phosphate decarboxylase / HUMPS family protein; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily. (216 aa)
pyrIAspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa)
pyrBAspartate carbamoyltransferase; Locus tag in AE006468 is STM4460; pyrB; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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