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pflA pflA EHY70158.1 EHY70158.1 ydeM_2 ydeM_2 EHY71548.1 EHY71548.1 hemN hemN EHY68275.1 EHY68275.1 rlmN rlmN queE queE EHY68667.1 EHY68667.1 EHY68917.1 EHY68917.1 ygiQ ygiQ atsB atsB lipA lipA chuR_2 chuR_2 miaB miaB yjjW yjjW epmB epmB EHY67132.1 EHY67132.1 bioB bioB moaA moaA EHY69740.1 EHY69740.1 rimO rimO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pflAPyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (277 aa)
EHY70158.1Hypothetical protein; KEGG: vfi:VF_A0208 1.5e-75 arylsulfatase regulator (Fe-S oxidoreductase) K06871; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM1287. (364 aa)
ydeM_2Radical SAM domain protein; KEGG: vfi:VF_A0208 1.4e-72 arylsulfatase regulator (Fe-S oxidoreductase) K06871; Psort location: Cytoplasmic, score: 9.26. (398 aa)
EHY71548.1Radical SAM domain protein; KEGG: vfi:VF_A0208 4.1e-68 arylsulfatase regulator (Fe-S oxidoreductase) K06871; Psort location: Cytoplasmic, score: 9.97. (413 aa)
hemNKEGG: stm:STM4004 6.6e-242 hemN; coproporphyrinogen III oxidase; K02495 oxygen-independent coproporphyrinogen III oxidase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM4004; hemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
EHY68275.1Radical SAM domain protein; KEGG: vfi:VF_A0208 2.4e-70 arylsulfatase regulator (Fe-S oxidoreductase) K06871; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3966. (431 aa)
rlmNRadical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (388 aa)
queERadical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (232 aa)
EHY68667.1Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa)
EHY68917.1Radical SAM protein family; KEGG: vfi:VF_2123 4.8e-113 yhcC; Fe-S oxidoreductase K07139; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3329; yhcC. (309 aa)
ygiQRadical SAM domain protein; KEGG: vfi:VF_1726 4.5e-259 ygiQ; hypothetical protein K03423; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3168; ygiR. (723 aa)
atsBSerine-type sulfatase anaerobic maturase AtsB; KEGG: vfi:VF_A0208 1.8e-58 arylsulfatase regulator (Fe-S oxidoreductase) K06871; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3123. (394 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
chuR_2Radical SAM domain protein; KEGG: vfi:VF_A0208 6.0e-74 arylsulfatase regulator (Fe-S oxidoreductase) K06871; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0036. (396 aa)
miaBtRNA-I(6)A37 thiotransferase enzyme MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (474 aa)
yjjWRadical SAM domain protein; Locus tag in AE006468 is STM4565; yjjW. (244 aa)
epmBKamA family protein; Locus tag in AE006468 is STM4333; yjeK. (342 aa)
EHY67132.1Thiazole biosynthesis protein ThiH; Locus tag in AE006468 is STM4159; thiH. (377 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (346 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
EHY69740.1Glycyl-radical enzyme activating family protein; KEGG: seg:SG0825 7.1e-158 pflE; putative pyruvate formate-lyase 3 activating enzyme K04069; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0844; pflE. (299 aa)
rimOMiaB-like tRNA modifying enzyme YliG; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (447 aa)
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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