STRINGSTRING
nrdG nrdG mogA mogA EHY69046.1 EHY69046.1 folK folK ybaX ybaX EHY69611.1 EHY69611.1 moaA moaA moaB moaB moaC moaC EHY69703.1 EHY69703.1 EHY69740.1 EHY69740.1 EHY69743.1 EHY69743.1 pflA pflA pabC pabC ribA ribA pabB pabB ntpA ntpA folE folE EHY71433.1 EHY71433.1 queD queD queE queE queF queF folB folB lpoA lpoA EHY68884.1 EHY68884.1 EHY67805.1 EHY67805.1 phoU phoU EHY67580.1 EHY67580.1 mobA mobA STY3815 STY3815 fieF fieF yjjW yjjW
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nrdGAnaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa)
mogAKEGG: hpa:HPAG1_0784 9.9e-42 mogA; molybdenum cofactor biosynthesis protein K03831; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0008; mog. (196 aa)
EHY69046.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (159 aa)
folKKEGG: ses:SARI_02814 2.6e-73 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; K00950 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; locus tag in AE006468 is STM0183; folK. (159 aa)
ybaXExsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa)
EHY69611.1Hypothetical protein; KEGG: hip:CGSHiEE_02770 1.1e-81 seryl-tRNA synthetase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0711; ybgI. (247 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
moaBMolybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (170 aa)
moaCMolybdenum cofactor biosynthesis protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa)
EHY69703.1Molybdopterin converting factor, subunit 2; Locus tag in AE006468 is STM0806; moaE. (150 aa)
EHY69740.1Glycyl-radical enzyme activating family protein; KEGG: seg:SG0825 7.1e-158 pflE; putative pyruvate formate-lyase 3 activating enzyme K04069; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0844; pflE. (299 aa)
EHY69743.1Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (411 aa)
pflAPyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (277 aa)
pabCAminodeoxychorismate lyase; KEGG: sew:SeSA_A1274 1.0e-110 pabC; 4-amino-4-deoxychorismate lyase K02619; locus tag in AE006468 is STM1198; pabC. (269 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. (225 aa)
pabBKEGG: sea:SeAg_B1307 1.6e-240 pabB; aminodeoxychorismate synthase, component I; K01665 para-aminobenzoate synthetase component I; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1824; pabB. (454 aa)
ntpAHydrolase, NUDIX family; Locus tag in AE006468 is STM1900; ntpA. (127 aa)
folEGTP cyclohydrolase I; KEGG: seg:SG2230 8.9e-112 folE; GTP cyclohydrolase I K01495; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2193; folE. (222 aa)
EHY71433.1Protein FolC; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. (422 aa)
queD6-pyruvoyl tetrahydropterin synthase/QueD family protein; KEGG: sty:STY3077 2.5e-43 putative 6-pyruvoyl tetrahydrobiopterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase; locus tag in AE006468 is STM2949; ptpS. (86 aa)
queERadical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (232 aa)
queFQueuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (282 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa)
lpoAHypothetical protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (683 aa)
EHY68884.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa)
EHY67805.1KEGG: seh:SeHA_C3774 2.9e-97 pabA; para-aminobenzoate synthase component II; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3469; pabA. (187 aa)
phoUPhosphate transport system regulatory protein PhoU; Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions. (241 aa)
EHY67580.1Molybdopterin-guanine dinucleotide biosynthesis protein B; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3993; mobB. (172 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (194 aa)
STY3815MOSC domain protein; KEGG: hip:CGSHiEE_01660 3.9e-15 uridine phosphorylase; locus tag in AE006468 is STM4056; yiiM. (224 aa)
fieFFerrous iron efflux protein F; Cation-efflux transporter that may have a role in detoxification. (300 aa)
yjjWRadical SAM domain protein; Locus tag in AE006468 is STM4565; yjjW. (244 aa)
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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