STRINGSTRING
AKB11785.1 AKB11785.1 AKB11787.1 AKB11787.1 AKB11788.1 AKB11788.1 nifH nifH AKB11846.1 AKB11846.1 AKB11847.1 AKB11847.1 AKB11851.1 AKB11851.1 AKB11852.1 AKB11852.1 AKB11864.1 AKB11864.1 purD purD pyrE pyrE pyrG pyrG AKB11912.1 AKB11912.1 AKB11915.1 AKB11915.1 AKB12096.1 AKB12096.1 AKB12097.1 AKB12097.1 AKB12102.1 AKB12102.1 metXA metXA AKB12117.1 AKB12117.1 gatE gatE AKB12140.1 AKB12140.1 carA carA carB carB argG argG AKB12157.1 AKB12157.1 AKB12181.1 AKB12181.1 AKB12265.1 AKB12265.1 trpE trpE trpF trpF trpD trpD trpA trpA trpB trpB trpC trpC AKB12321.1 AKB12321.1 hcp hcp AKB12407.1 AKB12407.1 AKB12436.1 AKB12436.1 AKB12440.1 AKB12440.1 aspS aspS rpiA rpiA purQ purQ purS purS hisE hisE AKB12595.1 AKB12595.1 aroK aroK AKB12601.1 AKB12601.1 purE purE AKB12604.1 AKB12604.1 ndk ndk pdxT pdxT pdxS pdxS AKB12709.1 AKB12709.1 argH argH gatD gatD AKB12741.1 AKB12741.1 AKB12751.1 AKB12751.1 AKB12781.1 AKB12781.1 argC argC argJ argJ AKB12839.1 AKB12839.1 glyA glyA folD folD AKB12844.1 AKB12844.1 AKB12845.1 AKB12845.1 hisD hisD trpB-2 trpB-2 purF purF hisH hisH AKB12989.1 AKB12989.1 pyrC pyrC pyrF pyrF AKB13088.1 AKB13088.1 cysS cysS lysA lysA hpt hpt trpF-2 trpF-2 AKB13189.1 AKB13189.1 proC proC proB proB proA proA AKB13205.1 AKB13205.1 purC purC purL purL AKB13252.1 AKB13252.1 AKB13262.1 AKB13262.1 AKB13302.1 AKB13302.1 AKB13320.1 AKB13320.1 AKB13321.1 AKB13321.1 AKB13322.1 AKB13322.1 AKB13323.1 AKB13323.1 AKB13375.1 AKB13375.1 AKB13391.1 AKB13391.1 aroA aroA thyA thyA gatB gatB gatA gatA gatC gatC argB argB guaAB guaAB pyrB pyrB pyrI pyrI dapB dapB dapA dapA tmk tmk AKB13482.1 AKB13482.1 guaAA guaAA aroD aroD aroE aroE AKB13542.1 AKB13542.1 mfnA mfnA AKB13581.1 AKB13581.1 AKB13611.1 AKB13611.1 AKB13612.1 AKB13612.1 surE surE AKB13656.1 AKB13656.1 asd asd AKB13658.1 AKB13658.1 hisC hisC argD argD purM purM AKB13670.1 AKB13670.1 AKB13677.1 AKB13677.1 AKB13687.1 AKB13687.1 mat mat hisG hisG hisA hisA hisB hisB AKB13785.1 AKB13785.1 AKB13804.1 AKB13804.1 hisF hisF aroC aroC pyrD pyrD pyrK pyrK AKB13883.1 AKB13883.1 dut dut AKB13908.1 AKB13908.1 pyrH pyrH purA purA AKB14066.1 AKB14066.1 AKB14067.1 AKB14067.1 AKB14118.1 AKB14118.1 AKB14119.1 AKB14119.1 AKB14171.1 AKB14171.1 prs prs AKB14262.1 AKB14262.1 AKB14313.1 AKB14313.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
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gene neighborhood
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AKB11785.1Aspartate aminotransferase. (380 aa)
AKB11787.1Inosine-5'-monophosphate dehydrogenase. (500 aa)
AKB11788.1Ferredoxin. (128 aa)
nifHNitrogenase reductase-like protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (299 aa)
AKB11846.1Nitrogenase vanadium-cofactor synthesis protein VnfE. (514 aa)
AKB11847.1Nitrogenase vanadium-cofactor synthesis protein VnfN. (449 aa)
AKB11851.1Nitrogenase vanadium-cofactor synthesis protein VnfE; Belongs to the NifD/NifK/NifE/NifN family. (442 aa)
AKB11852.1Nitrogenase vanadium-cofactor synthesis protein VnfN. (435 aa)
AKB11864.1Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (302 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (433 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (185 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa)
AKB11912.1AMP phosphohydrolase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. (506 aa)
AKB11915.1Asparagine synthetase (glutamine-hydrolyzing). (488 aa)
AKB12096.1Serine acetyltransferase; PaaD-like protein (DUF59) involved in Fe-S cluster assembly. (323 aa)
AKB12097.1Cysteine synthase. (308 aa)
AKB12102.1O-succinylhomoserine sulfhydrylase. (447 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (519 aa)
AKB12117.1NAD-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (417 aa)
gatEGlutamyl-tRNA(Gln) amidotransferase transferase subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (633 aa)
AKB12140.14-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (467 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (369 aa)
carBCarbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1090 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (394 aa)
AKB12157.1Hypothetical protein. (494 aa)
AKB12181.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (347 aa)
AKB12265.1Anthranilate synthase, amidotransferase component. (201 aa)
trpEAnthranilate synthase, aminase component; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (560 aa)
trpFPhosphoribosylanthranilate isomerase; Belongs to the TrpF family. (251 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (366 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (458 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (267 aa)
AKB12321.1LL-diaminopimelate aminotransferase, methanococcal. (385 aa)
hcpHydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (542 aa)
AKB12407.1Glutamine amidotransferase class-I. (231 aa)
AKB12436.1Shikimate kinase I. (169 aa)
AKB12440.1Glutamine synthetase type I. (506 aa)
aspSAspartyl-tRNA synthetase / Aspartyl-tRNA(Asn) synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (444 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (232 aa)
purQPhosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ a [...] (232 aa)
purSPhosphoribosylformylglycinamidine synthase, PurS subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (83 aa)
hisEPhosphoribosyl-ATP pyrophosphatase. (104 aa)
AKB12595.1Biosynthetic Aromatic amino acid aminotransferase alpha / Aspartate aminotransferase. (370 aa)
aroKShikimate kinase II. (287 aa)
AKB12601.1Chorismate mutase I. (95 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (133 aa)
AKB12604.1Cytidine kinase; Belongs to the carbohydrate kinase PfkB family. (299 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (143 aa)
pdxTPyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (199 aa)
pdxSPyridoxine biosynthesis glutamine amidotransferase, synthase subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa)
AKB12709.1Homoserine dehydrogenase. (332 aa)
argHArgininosuccinate lyase. (491 aa)
gatDGlutamyl-tRNA(Gln) amidotransferase asparaginase subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (424 aa)
AKB12741.1Hypothetical protein. (215 aa)
AKB12751.1Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. (411 aa)
AKB12781.1Glutamate dehydrogenase 2; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (377 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (337 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (395 aa)
AKB12839.1Phosphoribosylglycinamide formyltransferase. (202 aa)
glyASerine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
AKB12844.15,10-methylenetetrahydrofolate reductase. (293 aa)
AKB12845.1Coenzyme F420:L-glutamate ligase. (287 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
trpB-2Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (432 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (483 aa)
hisHImidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa)
AKB12989.1Phosphoribosyl-AMP cyclohydrolase. (93 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (468 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (221 aa)
AKB13088.1Archaeal S-adenosylmethionine synthetase. (410 aa)
cysSCysteinyl-tRNA synthetase. (471 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
hptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (190 aa)
trpF-2Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (224 aa)
AKB13189.1Serine O-acetyltransferase. (209 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (385 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (447 aa)
AKB13205.1Xanthine permease. (428 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (237 aa)
purLPhosphoribosylformylglycinamidine synthase, synthetase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (715 aa)
AKB13252.1Serine O-acetyltransferase. (141 aa)
AKB13262.1IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. (538 aa)
AKB13302.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (448 aa)
AKB13320.1Glutamine synthetase type I. (452 aa)
AKB13321.1Glutamine amidotransferase, class-II. (350 aa)
AKB13322.1Glutamate synthase [NADPH] large chain; Belongs to the glutamate synthase family. (503 aa)
AKB13323.1Glutamate synthase [NADPH] putative GlxC chain. (247 aa)
AKB13375.1GCN5-related N-acetyltransferase. (151 aa)
AKB13391.1Cation transporter. (370 aa)
aroA5-Enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa)
thyAThymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. (217 aa)
gatBAspartyl-tRNA(Asn) amidotransferase subunit B / Glutamyl-tRNA(Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (495 aa)
gatAAspartyl-tRNA(Asn) amidotransferase subunit A / Glutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (475 aa)
gatCAspartyl-tRNA(Asn) amidotransferase subunit C / Glutamyl-tRNA(Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (93 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa)
guaABGMP synthase (glutamine-hydrolyzing), ATP pyrophosphatase subunit; Catalyzes the synthesis of GMP from XMP. (305 aa)
pyrBAspartate carbamoyltransferase. (298 aa)
pyrIAspartate carbamoyltransferase regulatory chain (PyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (156 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (263 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa)
tmkThymidylate kinase. (205 aa)
AKB13482.1Phosphoserine phosphatase. (222 aa)
guaAAGMP synthase (glutamine-hydrolyzing), amidotransferase subunit; Catalyzes the synthesis of GMP from XMP. (189 aa)
aroD3-dehydroquinate dehydratase I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (242 aa)
aroEShikimate 5-dehydrogenase I alpha; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa)
AKB13542.1Prephenate and/or arogenate dehydrogenase (unknown specificity). (489 aa)
mfnAL-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (401 aa)
AKB13581.1Zinc metalloprotease. (349 aa)
AKB13611.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (348 aa)
AKB13612.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (344 aa)
surE5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (263 aa)
AKB13656.1Archaeosortase A. (288 aa)
asdPhosphatidylserine decarboxylase; Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer); Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily. (230 aa)
AKB13658.1CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (248 aa)
hisCAspartate aminotransferase / Histidinol-phosphate aminotransferase. (366 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (333 aa)
AKB13670.1Aspartokinase; Belongs to the aspartokinase family. (472 aa)
AKB13677.1dCMP deaminase. (167 aa)
AKB13687.1Ribosomal RNA adenine dimethylase. (238 aa)
matArchaeal S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (398 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (289 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (252 aa)
hisBImidazoleglycerol-phosphate dehydratase. (186 aa)
AKB13785.1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (203 aa)
AKB13804.1N-acetylglutamate synthase. (146 aa)
hisFImidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (273 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa)
pyrDDihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (301 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (259 aa)
AKB13883.1Transporter, LysE family. (218 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (159 aa)
AKB13908.1Aspartate-semialdehyde dehydrogenase. (342 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (233 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (424 aa)
AKB14066.1Ammonium transporter. (397 aa)
AKB14067.1Nitrogen regulatory protein P-II. (114 aa)
AKB14118.1Glutamate synthase [NADPH] small chain. (469 aa)
AKB14119.1Putative electron-transfer protein. (264 aa)
AKB14171.1Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (191 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (283 aa)
AKB14262.1Prephenate dehydratase. (316 aa)
AKB14313.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (405 aa)
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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