STRINGSTRING
AKB12611.1 AKB12611.1 AKB11773.1 AKB11773.1 ribL ribL AKB11804.1 AKB11804.1 AKB11829.1 AKB11829.1 carS carS AKB11891.1 AKB11891.1 AKB11892.1 AKB11892.1 mobA mobA AKB11942.1 AKB11942.1 cofC cofC AKB11985.1 AKB11985.1 AKB11988.1 AKB11988.1 rpoP rpoP AKB12085.1 AKB12085.1 thiM thiM AKB12120.1 AKB12120.1 AKB12138.1 AKB12138.1 AKB12150.1 AKB12150.1 nadK nadK AKB12202.1 AKB12202.1 AKB12204.1 AKB12204.1 AKB12207.1 AKB12207.1 AKB12213.1 AKB12213.1 AKB12220.1 AKB12220.1 AKB12233.1 AKB12233.1 AKB12241.1 AKB12241.1 AKB12244.1 AKB12244.1 AKB12250.1 AKB12250.1 dbh dbh AKB12337.1 AKB12337.1 AKB12351.1 AKB12351.1 AKB12354.1 AKB12354.1 AKB12436.1 AKB12436.1 AKB12491.1 AKB12491.1 AKB12498.1 AKB12498.1 mptE mptE aroK aroK AKB12604.1 AKB12604.1 ndk ndk thiI thiI AKB12722.1 AKB12722.1 AKB12746.1 AKB12746.1 AKB12749.1 AKB12749.1 AKB12752.1 AKB12752.1 AKB12753.1 AKB12753.1 rpoH rpoH AKB12757.1 AKB12757.1 AKB12758.1 AKB12758.1 AKB12759.1 AKB12759.1 rpoA2 rpoA2 AKB12785.1 AKB12785.1 ackA ackA pgk pgk pfkC pfkC cca cca coaD coaD AKB12856.1 AKB12856.1 rpoD rpoD cmk cmk adk adk AKB12931.1 AKB12931.1 AKB12968.1 AKB12968.1 AKB12983.1 AKB12983.1 AKB12997.1 AKB12997.1 AKB13005.1 AKB13005.1 AKB13043.1 AKB13043.1 cobS cobS AKB13128.1 AKB13128.1 AKB13130.1 AKB13130.1 AKB13141.1 AKB13141.1 AKB13150.1 AKB13150.1 rpoL rpoL cofD cofD AKB13188.1 AKB13188.1 proB proB dbh-2 dbh-2 AKB13308.1 AKB13308.1 AKB13381.1 AKB13381.1 polC polC argB argB AKB13457.1 AKB13457.1 tmk tmk AKB13513.1 AKB13513.1 AKB13514.1 AKB13514.1 AKB13515.1 AKB13515.1 dnaG dnaG kptA kptA AKB13587.1 AKB13587.1 AKB13589.1 AKB13589.1 polB polB thiL thiL ppk ppk priL priL AKB13658.1 AKB13658.1 AKB13670.1 AKB13670.1 AKB13713.1 AKB13713.1 AKB13729.1 AKB13729.1 AKB13785.1 AKB13785.1 AKB13818.1 AKB13818.1 ribK ribK AKB13844.1 AKB13844.1 rpoN rpoN AKB13872.1 AKB13872.1 mvk mvk AKB13876.1 AKB13876.1 AKB13880.1 AKB13880.1 AKB13886.1 AKB13886.1 pyrH pyrH AKB13953.1 AKB13953.1 priS priS dacZ dacZ AKB14008.1 AKB14008.1 AKB14072.1 AKB14072.1 AKB14120.1 AKB14120.1 AKB14148.1 AKB14148.1 AKB14149.1 AKB14149.1 AKB14155.1 AKB14155.1 AKB14172.1 AKB14172.1 AKB14176.1 AKB14176.1 AKB14178.1 AKB14178.1 AKB14188.1 AKB14188.1 prs prs AKB14259.1 AKB14259.1 AKB14268.1 AKB14268.1 AKB14269.1 AKB14269.1 AKB14300.1 AKB14300.1 AKB14303.1 AKB14303.1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AKB12611.1Response regulator receiver. (169 aa)
AKB11773.1Sensory transduction histidine kinase. (587 aa)
ribLFMN adenylyltransferase, type 3 archaeal; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (139 aa)
AKB11804.1Phytol kinase. (229 aa)
AKB11829.1Nucleotidyltransferase. (102 aa)
carSPhosphatidate cytidylyltransferase; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (175 aa)
AKB11891.1Hypothetical protein. (397 aa)
AKB11892.1Hypothetical protein. (179 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (225 aa)
AKB11942.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (803 aa)
cofC2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (208 aa)
AKB11985.1Delta 1-pyrroline-5-carboxylate synthetase. (219 aa)
AKB11988.1Sensory transduction histidine kinase. (1068 aa)
rpoPDNA-directed RNA polymerase subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (45 aa)
AKB12085.1Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY. (126 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (265 aa)
AKB12120.1Sensory transduction histidine kinase. (892 aa)
AKB12138.1Response regulator receiver. (126 aa)
AKB12150.1Nucleotidyltransferase. (100 aa)
nadKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (275 aa)
AKB12202.1Sensory transduction histidine kinase. (172 aa)
AKB12204.1Sensory transduction histidine kinase. (844 aa)
AKB12207.1Sensory transduction histidine kinase. (449 aa)
AKB12213.1Fructokinase. (320 aa)
AKB12220.1Metallo-beta-lactamase family protein. (456 aa)
AKB12233.1Mannose-6-phosphate isomerase, bifunctional enzyme. (446 aa)
AKB12241.1Hypothetical protein. (503 aa)
AKB12244.1Hypothetical protein. (865 aa)
AKB12250.1Hypothetical protein. (297 aa)
dbhDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (367 aa)
AKB12337.1Sensory transduction histidine kinase. (692 aa)
AKB12351.1Serine/threonine protein kinase. (376 aa)
AKB12354.1Sensory transduction histidine kinase. (1064 aa)
AKB12436.1Shikimate kinase I. (169 aa)
AKB12491.1Sensory transduction histidine kinase. (272 aa)
AKB12498.1Response regulator receiver. (291 aa)
mptE6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (213 aa)
aroKShikimate kinase II. (287 aa)
AKB12604.1Cytidine kinase; Belongs to the carbohydrate kinase PfkB family. (299 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (143 aa)
thiItRNA S(4)U 4-thiouridine synthase (former ThiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (506 aa)
AKB12722.1ABC1 family protein. (551 aa)
AKB12746.1Pantoate kinase, archaeal. (337 aa)
AKB12749.1Nucleotidyltransferase. (298 aa)
AKB12752.1Sensory transduction histidine kinase. (1362 aa)
AKB12753.1Two-component system response regulator. (143 aa)
rpoHDNA-directed RNA polymerase subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (78 aa)
AKB12757.1DNA-directed RNA polymerase subunit B''; Belongs to the RNA polymerase beta chain family. (531 aa)
AKB12758.1DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (604 aa)
AKB12759.1DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (854 aa)
rpoA2DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (392 aa)
AKB12785.1Hypothetical protein. (225 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (408 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa)
pfkCADP-dependent phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (490 aa)
ccatRNA nucleotidyltransferase, archaeal type; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (461 aa)
coaDPhosphopantetheine adenylyltransferase, type II eukaryotic; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (156 aa)
AKB12856.1Phosphomethylpyrimidine kinase; Thiamin-phosphate synthase ThiN. (452 aa)
rpoDDNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (264 aa)
cmkCytidylate kinase. (180 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa)
AKB12931.1Glucose-1-phosphate thymidylyltransferase. (252 aa)
AKB12968.1Signal-transducing histidine kinase. (570 aa)
AKB12983.1Hydrogenase expression/formation protein. (441 aa)
AKB12997.1Serine/threonine protein kinase. (260 aa)
AKB13005.1Archaeal DNA polymerase I. (931 aa)
AKB13043.1tRNAHis-5'-guanylyltransferase. (243 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (280 aa)
AKB13128.1Sensory transduction histidine kinase. (507 aa)
AKB13130.1Sensory transduction histidine kinase. (1168 aa)
AKB13141.1Hypothetical protein. (147 aa)
AKB13150.1DNA polymerase X family. (584 aa)
rpoLDNA-directed RNA polymerase subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (92 aa)
cofD2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (309 aa)
AKB13188.1Putative stress-responsive transcriptional regulator. (58 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (385 aa)
dbh-2DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (356 aa)
AKB13308.1Sensory transduction histidine kinase. (451 aa)
AKB13381.1Transcriptional regulator. (281 aa)
polCArchaeal DNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1146 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa)
AKB13457.1UTP--glucose-1-phosphate uridylyltransferase. (295 aa)
tmkThymidylate kinase. (205 aa)
AKB13513.1Sensory transduction histidine kinase. (403 aa)
AKB13514.1Sensory transduction histidine kinase. (608 aa)
AKB13515.1Two-component response regulator. (125 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (518 aa)
kptARNA:NAD 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. (207 aa)
AKB13587.1Signal transduction histidine kinase CheA. (675 aa)
AKB13589.1Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY. (121 aa)
polBArchaeal DNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (641 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (340 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (728 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (386 aa)
AKB13658.1CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (248 aa)
AKB13670.1Aspartokinase; Belongs to the aspartokinase family. (472 aa)
AKB13713.1Molybdenum cofactor biosynthesis protein MoaB. (179 aa)
AKB13729.1Hypothetical protein. (88 aa)
AKB13785.1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (203 aa)
AKB13818.1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (194 aa)
ribKDNA-binding HTH domain in riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (225 aa)
AKB13844.1Sensory transduction histidine kinase. (117 aa)
rpoNDNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (62 aa)
AKB13872.1DNA-directed RNA polymerase subunit K. (37 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (301 aa)
AKB13876.1Isopentenyl phosphate kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (262 aa)
AKB13880.1Pyruvate,phosphate dikinase. (883 aa)
AKB13886.1Sensory transduction histidine kinase. (658 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (233 aa)
AKB13953.1Sensory transduction histidine kinase. (624 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (420 aa)
dacZHypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. (291 aa)
AKB14008.1Triphosphoribosyl-dephospho-CoA synthetase. (342 aa)
AKB14072.1Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
AKB14120.1Mannose-1-phosphate guanylyltransferase (GDP); Mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 2 family. (458 aa)
AKB14148.1Nicotinamide-nucleotide adenylyltransferase, NadM family. (173 aa)
AKB14149.1AMP/CMP kinase AK6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (182 aa)
AKB14155.1Hypothetical protein. (228 aa)
AKB14172.1YgjD/Kae1/Qri7 family, required for N6-threonylcarbamoyl adenosine t(6)A37 modification in tRNA; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belo [...] (545 aa)
AKB14176.1Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (195 aa)
AKB14178.1DNA-directed RNA polymerase subunit E'. (194 aa)
AKB14188.1Galactose-1-phosphate uridylyltransferase. (334 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (283 aa)
AKB14259.1DNA polymerase, beta-like region. (313 aa)
AKB14268.1Phytol kinase. (198 aa)
AKB14269.1Mannose-1-phosphate guanylyltransferase; Phosphomannomutase. (392 aa)
AKB14300.1N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase. (397 aa)
AKB14303.1Glucose-1-phosphate thymidylyltransferase. (405 aa)
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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