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| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | AKB11782.1 | Serine--glyoxylate aminotransferase. (383 aa) |
| | AKB11783.1 | Riboflavin synthase archaeal. (154 aa) |
| | AKB11784.1 | 6,7-dimethyl-8-ribityllumazine synthase. (134 aa) |
| | AKB11787.1 | Inosine-5'-monophosphate dehydrogenase. (500 aa) |
| | AKB11788.1 | Ferredoxin. (128 aa) |
| | thi4 | Thiazole biosynthetic enzyme Thi4; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (260 aa) |
| | serS | Seryl-tRNA synthetase, archaeal; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily. (502 aa) |
| | thiC | Thiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (427 aa) |
| | AKB11853.1 | Hypothetical protein. (77 aa) |
| | AKB11864.1 | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (302 aa) |
| | AKB11870.1 | Ferredoxin oxidoreductase. (438 aa) |
| | AKB11872.1 | Cysteate synthase; Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. (416 aa) |
| | AKB11896.1 | Tetrahydromethanopterin:alpha-L-glutamate ligase. (328 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (485 aa) |
| | AKB11942.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (803 aa) |
| | cofG | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil; Belongs to the radical SAM superfamily. CofG family. (290 aa) |
| | cofH | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (375 aa) |
| | cofH-2 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (385 aa) |
| | AKB11995.1 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. (258 aa) |
| | AKB12003.1 | Putative methyltransferase. (289 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (265 aa) |
| | thiE | Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (225 aa) |
| | AKB12096.1 | Serine acetyltransferase; PaaD-like protein (DUF59) involved in Fe-S cluster assembly. (323 aa) |
| | AKB12097.1 | Cysteine synthase. (308 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | AKB12102.1 | O-succinylhomoserine sulfhydrylase. (447 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (519 aa) |
| | AKB12140.1 | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (467 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (369 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1090 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (394 aa) |
| | AKB12159.1 | Aminoacyl-histidine dipeptidase (Peptidase D). (507 aa) |
| | gap | NAD(P)-dependent glyceraldehyde 3-phosphate dehydrogenase archaeal. (335 aa) |
| | AKB12190.1 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. (405 aa) |
| | AKB12220.1 | Metallo-beta-lactamase family protein. (456 aa) |
| | AKB12248.1 | Dimethylamine methyltransferase corrinoid protein. (216 aa) |
| | trpE | Anthranilate synthase, aminase component; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (560 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (251 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (366 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (458 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (267 aa) |
| | AKB12288.1 | Hypothetical protein. (240 aa) |
| | AKB12321.1 | LL-diaminopimelate aminotransferase, methanococcal. (385 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (238 aa) |
| | AKB12436.1 | Shikimate kinase I. (169 aa) |
| | AKB12437.1 | Ornithine decarboxylase. (390 aa) |
| | AKB12440.1 | Glutamine synthetase type I. (506 aa) |
| | mptE | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (213 aa) |
| | AKB12521.1 | Xanthine-guanine phosphoribosyltransferase. (107 aa) |
| | AKB12522.1 | Xanthine-guanine phosphoribosyltransferase. (56 aa) |
| | AKB12554.1 | O-succinylhomoserine sulfhydrylase. (77 aa) |
| | AKB12562.1 | Ferredoxin oxidoreductase. (414 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (431 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase. (104 aa) |
| | aroK | Shikimate kinase II. (287 aa) |
| | AKB12601.1 | Chorismate mutase I. (95 aa) |
| | AKB12613.1 | Hydrolase, HAD superfamily. (248 aa) |
| | pdxT | Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (199 aa) |
| | pdxS | Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa) |
| | AKB12696.1 | Hypothetical protein. (149 aa) |
| | thiI | tRNA S(4)U 4-thiouridine synthase (former ThiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (506 aa) |
| | AKB12709.1 | Homoserine dehydrogenase. (332 aa) |
| | argH | Argininosuccinate lyase. (491 aa) |
| | AKB12785.1 | Hypothetical protein. (225 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (337 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (395 aa) |
| | AKB12821.1 | Substrate-specific component CbiM of cobalt ECF transporter. (205 aa) |
| | cbiN | Additional substrate-specific component CbiN of cobalt ECF transporter; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (113 aa) |
| | glyA | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa) |
| | AKB12842.1 | Dihydropteroate synthase; Alternative dihydrofolate reductase 2. (408 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) |
| | trpB-2 | Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (432 aa) |
| | AKB12856.1 | Phosphomethylpyrimidine kinase; Thiamin-phosphate synthase ThiN. (452 aa) |
| | AKB12927.1 | Glucose-6-phosphate isomerase. (242 aa) |
| | AKB12944.1 | Acetyltransferase. (208 aa) |
| | AKB12983.1 | Hydrogenase expression/formation protein. (441 aa) |
| | hisH | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa) |
| | AKB12989.1 | Phosphoribosyl-AMP cyclohydrolase. (93 aa) |
| | AKB13039.1 | Glucose-6-phosphate isomerase. (246 aa) |
| | nadA-2 | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | hisS | Histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (409 aa) |
| | cobD | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (328 aa) |
| | cobS | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (280 aa) |
| | AKB13114.1 | Putative adenosylcobinamide-phosphate guanylyltransferase CobY. (201 aa) |
| | AKB13118.1 | Dimethylamine methyltransferase corrinoid protein. (220 aa) |
| | AKB13141.1 | Hypothetical protein. (147 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | hpt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (190 aa) |
| | trpF-2 | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (224 aa) |
| | AKB13189.1 | Serine O-acetyltransferase. (209 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (385 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (447 aa) |
| | AKB13198.1 | Small primase-like proteins (Toprim domain); Belongs to the UPF0292 family. (146 aa) |
| | AKB13204.1 | 5-amino-6-(5-phosphoribosylamino)uracil reductase. (239 aa) |
| | AKB13232.1 | Metal-dependent hydrolases of the beta-lactamase superfamily I; PhnP protein. (246 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (237 aa) |
| | AKB13252.1 | Serine O-acetyltransferase. (141 aa) |
| | AKB13320.1 | Glutamine synthetase type I. (452 aa) |
| | AKB13322.1 | Glutamate synthase [NADPH] large chain; Belongs to the glutamate synthase family. (503 aa) |
| | AKB13338.1 | Cobalt-precorrin-8x methylmutase. (243 aa) |
| | AKB13339.1 | Cobalt-precorrin-3b C17-methyltransferase. (266 aa) |
| | AKB13340.1 | Cobalamin biosynthesis protein CbiG. (117 aa) |
| | AKB13341.1 | Cobalamin biosynthesis protein CbiG. (133 aa) |
| | AKB13342.1 | Cobalt-precorrin-4 C11-methyltransferase. (242 aa) |
| | AKB13343.1 | Cobalt-precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (202 aa) |
| | cbiT | Cobalt-precorrin-6y C15-methyltransferase (decarboxylating); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (184 aa) |
| | AKB13345.1 | 2-isopropylmalate synthase. (442 aa) |
| | AKB13346.1 | 3-isopropylmalate dehydrogenase. (342 aa) |
| | AKB13362.1 | Iron-sulfur cluster-binding protein. (247 aa) |
| | thiC-2 | Thiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (428 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa) |
| | AKB13384.1 | Xanthine-guanine phosphoribosyltransferase. (214 aa) |
| | aroA | 5-Enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | AKB13407.1 | Dihydrofolate reductase. (185 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (263 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa) |
| | AKB13446.1 | Acetyltransferase. (241 aa) |
| | AKB13458.1 | UDP-glucose dehydrogenase. (427 aa) |
| | AKB13476.1 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family. (244 aa) |
| | AKB13482.1 | Phosphoserine phosphatase. (222 aa) |
| | AKB13483.1 | Phosphoserine phosphatase. (285 aa) |
| | AKB13496.1 | 7,8 dihydropteroate synthase (methanopterin). (220 aa) |
| | AKB13499.1 | Undecaprenyl diphosphate synthase. (224 aa) |
| | aroA-2 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa) |
| | aroB | 3,7-dideoxy-D-threo-hepto-2, 6-diulosonate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (380 aa) |
| | aroD | 3-dehydroquinate dehydratase I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (242 aa) |
| | aroE | Shikimate 5-dehydrogenase I alpha; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa) |
| | AKB13542.1 | Prephenate and/or arogenate dehydrogenase (unknown specificity). (489 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (222 aa) |
| | AKB13551.1 | 2-isopropylmalate synthase. (430 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (340 aa) |
| | AKB13628.1 | Inositol-1-phosphate synthase. (366 aa) |
| | AKB13629.1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (369 aa) |
| | cbiA | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (439 aa) |
| | hisC | Aspartate aminotransferase / Histidinol-phosphate aminotransferase. (366 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa) |
| | AKB13670.1 | Aspartokinase; Belongs to the aspartokinase family. (472 aa) |
| | AKB13689.1 | Proline reductase for pyrrolysine biosynthesis. (259 aa) |
| | AKB13690.1 | Pyrrolysine synthetase. (363 aa) |
| | AKB13691.1 | Proline 2-methylase for pyrrolysine biosynthesis. (350 aa) |
| | AKB13740.1 | 3-isopropylmalate dehydrogenase. (375 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (289 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (252 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (186 aa) |
| | AKB13797.1 | 3-octaprenyl-4-hydroxybenzoate decarboxylase. (424 aa) |
| | AKB13812.1 | Galactoside O-acetyltransferase. (194 aa) |
| | AKB13814.1 | Cobalt-precorrin-6y C5-methyltransferase. (195 aa) |
| | cbiD | Cobalt-precorrin-6 synthase, anaerobic; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (339 aa) |
| | AKB13820.1 | Dimethylamine methyltransferase corrinoid protein. (208 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (273 aa) |
| | ribK | DNA-binding HTH domain in riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (225 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (246 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | AKB13865.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (523 aa) |
| | AKB13880.1 | Pyruvate,phosphate dikinase. (883 aa) |
| | aroA-3 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (286 aa) |
| | AKB13908.1 | Aspartate-semialdehyde dehydrogenase. (342 aa) |
| | AKB13985.1 | Iron-sulfur cluster-binding protein. (359 aa) |
| | AKB13992.1 | Pyruvate carboxyl transferase subunit A. (493 aa) |
| | AKB13995.1 | Phosphoserine phosphatase. (319 aa) |
| | AKB14010.1 | Indolepyruvate oxidoreductase subunit IorA. (223 aa) |
| | AKB14045.1 | Hypothetical protein. (170 aa) |
| | AKB14051.1 | Queuosine biosynthesis QueD, PTPS-I. (116 aa) |
| | queE | Queuosine Biosynthesis QueE Radical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (255 aa) |
| | queC | Queuosine Biosynthesis QueC ATPase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (231 aa) |
| | AKB14073.1 | Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase. (307 aa) |
| | AKB14074.1 | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Belongs to the UPF0284 family. (349 aa) |
| | cimA | (R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (483 aa) |
| | AKB14111.1 | Acetolactate synthase small subunit. (161 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa) |
| | hacB | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] (166 aa) |
| | AKB14136.1 | Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. (330 aa) |
| | uppS | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (298 aa) |
| | AKB14163.1 | Acetyltransferase. (177 aa) |
| | cbiX | Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (130 aa) |
| | cbiA-2 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (495 aa) |
| | AKB14262.1 | Prephenate dehydratase. (316 aa) |
| | leuC-2 | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa) |
| | AKB14288.1 | Haloacid dehalogenase-like hydrolase. (196 aa) |
| | AKB14293.1 | Uroporphyrinogen-III synthase. (272 aa) |
| | AKB14313.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (405 aa) |
