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AKB12513.1 AKB12513.1 thiC thiC AKB11886.1 AKB11886.1 AKB11915.1 AKB11915.1 AKB11933.1 AKB11933.1 AKB11962.1 AKB11962.1 AKB11966.1 AKB11966.1 AKB11968.1 AKB11968.1 cofG cofG cofH cofH cofH-2 cofH-2 AKB12041.1 AKB12041.1 nadA nadA AKB12107.1 AKB12107.1 AKB12115.1 AKB12115.1 AKB12131.1 AKB12131.1 AKB12132.1 AKB12132.1 AKB12133.1 AKB12133.1 AKB12310.1 AKB12310.1 AKB12320.1 AKB12320.1 AKB12364.1 AKB12364.1 hcp hcp AKB12408.1 AKB12408.1 AKB12519.1 AKB12519.1 AKB12539.1 AKB12539.1 AKB12550.1 AKB12550.1 AKB12552.1 AKB12552.1 AKB12561.1 AKB12561.1 leuC leuC AKB12685.1 AKB12685.1 AKB12686.1 AKB12686.1 AKB12800.1 AKB12800.1 purF purF AKB12866.1 AKB12866.1 AKB12872.1 AKB12872.1 AKB12877.1 AKB12877.1 AKB12959.1 AKB12959.1 AKB13034.1 AKB13034.1 AKB13064.1 AKB13064.1 nadA-2 nadA-2 AKB13152.1 AKB13152.1 AKB13158.1 AKB13158.1 AKB13174.1 AKB13174.1 AKB13291.1 AKB13291.1 AKB13322.1 AKB13322.1 AKB13330.1 AKB13330.1 AKB13331.1 AKB13331.1 thiC-2 thiC-2 AKB13397.1 AKB13397.1 AKB13419.1 AKB13419.1 AKB13554.1 AKB13554.1 AKB13600.1 AKB13600.1 AKB13602.1 AKB13602.1 taw1 taw1 moaA moaA priL priL AKB13691.1 AKB13691.1 AKB13795.1 AKB13795.1 hdrD hdrD AKB14010.1 AKB14010.1 AKB14049.1 AKB14049.1 queE queE AKB14059.1 AKB14059.1 cdhE cdhE cdhA cdhA AKB14277.1 AKB14277.1 AKB14278.1 AKB14278.1 AKB14279.1 AKB14279.1 leuC-2 leuC-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKB12513.1Molybdenum cofactor biosynthesis protein MoaA. (264 aa)
thiCThiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (427 aa)
AKB11886.1Carbon monoxide dehydrogenase CooS subunit. (637 aa)
AKB11915.1Asparagine synthetase (glutamine-hydrolyzing). (488 aa)
AKB11933.1Indolepyruvate oxidoreductase subunit IorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (600 aa)
AKB11962.1Ketoisovalerate oxidoreductase subunit VorD. (136 aa)
AKB11966.1Hypothetical protein. (183 aa)
AKB11968.1Ferredoxin. (53 aa)
cofG7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil; Belongs to the radical SAM superfamily. CofG family. (290 aa)
cofH7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (375 aa)
cofH-27,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (385 aa)
AKB12041.1Pyruvate formate lyase-activating enzyme 1. (350 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa)
AKB12107.1Tungsten-containing aldehyde:ferredoxin oxidoreductase. (587 aa)
AKB12115.1PUA-PAPS reductase like fusion. (766 aa)
AKB12131.1Acetyl-CoA decarbonylase/synthase complex subunit gamma 1. (154 aa)
AKB12132.1Rubredoxin. (93 aa)
AKB12133.1CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (798 aa)
AKB12310.1Fumarate hydratase class I, aerobic; L(+)-tartrate dehydratase alpha subunit. (280 aa)
AKB12320.1Ferredoxin domain containing protein. (181 aa)
AKB12364.1Indolepyruvate oxidoreductase subunit IorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (623 aa)
hcpHydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (542 aa)
AKB12408.1Molybdenum cofactor biosynthesis protein A. (494 aa)
AKB12519.1Pyruvate:ferredoxin oxidoreductase, beta subunit. (296 aa)
AKB12539.1Putative arylsulfatase regulatory protein. (382 aa)
AKB12550.1Rubredoxin. (160 aa)
AKB12552.1Sulfite reductase-related protein. (285 aa)
AKB12561.1Hypothetical protein. (224 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (431 aa)
AKB12685.1Hypothetical protein. (265 aa)
AKB12686.1Hypothetical protein. (265 aa)
AKB12800.1Uracil-DNA glycosylase, family 4. (152 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (483 aa)
AKB12866.1(dimethylallyl)adenosine tRNA methylthiotransferase. (436 aa)
AKB12872.1Methanophenazine hydrogenase small subunit precursor. (403 aa)
AKB12877.1Methanophenazine hydrogenase small subunit precursor. (381 aa)
AKB12959.1Indolepyruvate oxidoreductase subunit IorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (600 aa)
AKB13034.1Histone acetyltransferase, ELP3 family. (551 aa)
AKB13064.1Radical SAM domain protein. (319 aa)
nadA-2Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa)
AKB13152.1Ferredoxin domain containing protein. (186 aa)
AKB13158.1Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (313 aa)
AKB13174.1Coenzyme F420 hydrogenase subunit gamma. (253 aa)
AKB13291.1Aldehyde ferredoxin oxidoreductase. (572 aa)
AKB13322.1Glutamate synthase [NADPH] large chain; Belongs to the glutamate synthase family. (503 aa)
AKB13330.1CoB--CoM heterodisulfide reductase subunit C. (161 aa)
AKB13331.1CoB--CoM heterodisulfide reductase subunit B. (300 aa)
thiC-2Thiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (428 aa)
AKB13397.1Methyl coenzyme M reductase associated protein / Fe-S oxidoreductase, related to NifB/MoaA family. (411 aa)
AKB13419.1Histone acetyltransferase, ELP3 family. (346 aa)
AKB13554.1Fe-S OXIDOREDUCTASE. (763 aa)
AKB13600.1Pyruvate:ferredoxin oxidoreductase, beta subunit. (296 aa)
AKB13602.1Pyruvate:ferredoxin oxidoreductase, delta subunit. (111 aa)
taw1Fe-S OXIDOREDUCTASE Wyeosine biosynthesis; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (340 aa)
moaAMolybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (332 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (386 aa)
AKB13691.1Proline 2-methylase for pyrrolysine biosynthesis. (350 aa)
AKB13795.1Aconitate hydratase. (934 aa)
hdrDCoB--CoM heterodisulfide reductase 2 iron-sulfur subunit D; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Electrons probably transfer from phenazine to the high potential 4Fe cluster in HdrD subunit, then to the low potential heme in HdrE subunit and finally to CoM-S-S-CoB. (409 aa)
AKB14010.1Indolepyruvate oxidoreductase subunit IorA. (223 aa)
AKB14049.1Ferredoxin. (58 aa)
queEQueuosine Biosynthesis QueE Radical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (255 aa)
AKB14059.1Energy-conserving hydrogenase (ferredoxin), subunit F. (119 aa)
cdhE5-tetrahydromethanopterin:corrinoid iron-sulfur protein methyltransferase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. (469 aa)
cdhACO dehydrogenase/acetyl-CoA synthase subunit alpha, CO dehydrogenase subcomplex; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (803 aa)
AKB14277.1CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (803 aa)
AKB14278.1CoB--CoM heterodisulfide reductase subunit C. (236 aa)
AKB14279.1CoB--CoM heterodisulfide reductase subunit B. (314 aa)
leuC-2Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa)
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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