node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKB12274.1 | AKB13625.1 | MSTHT_0516 | MSTHT_1867 | Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Ribonucleotide reductase of class III (anaerobic), large subunit. | 0.497 |
AKB12274.1 | cmk | MSTHT_0516 | MSTHT_1138 | Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Cytidylate kinase. | 0.903 |
AKB12274.1 | ndk | MSTHT_0516 | MSTHT_0877 | Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.930 |
AKB12274.1 | thyA | MSTHT_0516 | MSTHT_1647 | Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.888 |
AKB12274.1 | tmk | MSTHT_0516 | MSTHT_1720 | Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Thymidylate kinase. | 0.965 |
AKB12604.1 | cmk | MSTHT_0846 | MSTHT_1138 | Cytidine kinase; Belongs to the carbohydrate kinase PfkB family. | Cytidylate kinase. | 0.922 |
AKB12604.1 | ndk | MSTHT_0846 | MSTHT_0877 | Cytidine kinase; Belongs to the carbohydrate kinase PfkB family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.408 |
AKB12604.1 | pyrD | MSTHT_0846 | MSTHT_2095 | Cytidine kinase; Belongs to the carbohydrate kinase PfkB family. | Dihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. | 0.424 |
AKB12604.1 | surE | MSTHT_0846 | MSTHT_1889 | Cytidine kinase; Belongs to the carbohydrate kinase PfkB family. | 5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.906 |
AKB12979.1 | pyrD | MSTHT_1221 | MSTHT_2095 | Orotate phosphoribosyltransferase related protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Dihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. | 0.911 |
AKB12979.1 | pyrE | MSTHT_1221 | MSTHT_0109 | Orotate phosphoribosyltransferase related protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.917 |
AKB12979.1 | pyrF | MSTHT_1221 | MSTHT_1325 | Orotate phosphoribosyltransferase related protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.928 |
AKB12979.1 | pyrK | MSTHT_1221 | MSTHT_2096 | Orotate phosphoribosyltransferase related protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.900 |
AKB13625.1 | AKB12274.1 | MSTHT_1867 | MSTHT_0516 | Ribonucleotide reductase of class III (anaerobic), large subunit. | Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.497 |
AKB13625.1 | dut | MSTHT_1867 | MSTHT_2144 | Ribonucleotide reductase of class III (anaerobic), large subunit. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.914 |
AKB13625.1 | ndk | MSTHT_1867 | MSTHT_0877 | Ribonucleotide reductase of class III (anaerobic), large subunit. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.922 |
AKB13625.1 | pyrG | MSTHT_1867 | MSTHT_0130 | Ribonucleotide reductase of class III (anaerobic), large subunit. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.917 |
AKB13677.1 | cmk | MSTHT_1919 | MSTHT_1138 | dCMP deaminase. | Cytidylate kinase. | 0.900 |
AKB13677.1 | dut | MSTHT_1919 | MSTHT_2144 | dCMP deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.931 |
AKB13677.1 | surE | MSTHT_1919 | MSTHT_1889 | dCMP deaminase. | 5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.901 |