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pyrE pyrE pyrG pyrG carA carA carB carB AKB12274.1 AKB12274.1 AKB12604.1 AKB12604.1 ndk ndk cmk cmk AKB12979.1 AKB12979.1 pyrC pyrC pyrF pyrF thyA thyA pyrB pyrB pyrI pyrI tmk tmk AKB13625.1 AKB13625.1 surE surE AKB13677.1 AKB13677.1 pyrD pyrD pyrK pyrK dut dut pyrH pyrH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (185 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (369 aa)
carBCarbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1090 aa)
AKB12274.1Ribonucleotide reductase of class II (coenzyme B12-dependent); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (583 aa)
AKB12604.1Cytidine kinase; Belongs to the carbohydrate kinase PfkB family. (299 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (143 aa)
cmkCytidylate kinase. (180 aa)
AKB12979.1Orotate phosphoribosyltransferase related protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (204 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (468 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (221 aa)
thyAThymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. (217 aa)
pyrBAspartate carbamoyltransferase. (298 aa)
pyrIAspartate carbamoyltransferase regulatory chain (PyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (156 aa)
tmkThymidylate kinase. (205 aa)
AKB13625.1Ribonucleotide reductase of class III (anaerobic), large subunit. (753 aa)
surE5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (263 aa)
AKB13677.1dCMP deaminase. (167 aa)
pyrDDihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (301 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (259 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (159 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (233 aa)
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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