node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKB12190.1 | AKB12709.1 | MSTHT_0432 | MSTHT_0951 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Homoserine dehydrogenase. | 0.458 |
AKB12190.1 | AKB13670.1 | MSTHT_0432 | MSTHT_1912 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Aspartokinase; Belongs to the aspartokinase family. | 0.487 |
AKB12190.1 | AKB14136.1 | MSTHT_0432 | MSTHT_2378 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. | 0.965 |
AKB12190.1 | hacB | MSTHT_0432 | MSTHT_2374 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] | 0.966 |
AKB12190.1 | leuC-2 | MSTHT_0432 | MSTHT_2523 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.965 |
AKB12321.1 | AKB12709.1 | MSTHT_0563 | MSTHT_0951 | LL-diaminopimelate aminotransferase, methanococcal. | Homoserine dehydrogenase. | 0.468 |
AKB12321.1 | AKB13670.1 | MSTHT_0563 | MSTHT_1912 | LL-diaminopimelate aminotransferase, methanococcal. | Aspartokinase; Belongs to the aspartokinase family. | 0.525 |
AKB12321.1 | dapA | MSTHT_0563 | MSTHT_1670 | LL-diaminopimelate aminotransferase, methanococcal. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.469 |
AKB12321.1 | dapB | MSTHT_0563 | MSTHT_1669 | LL-diaminopimelate aminotransferase, methanococcal. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.933 |
AKB12321.1 | lysA | MSTHT_0563 | MSTHT_1393 | LL-diaminopimelate aminotransferase, methanococcal. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.715 |
AKB12709.1 | AKB12190.1 | MSTHT_0951 | MSTHT_0432 | Homoserine dehydrogenase. | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.458 |
AKB12709.1 | AKB12321.1 | MSTHT_0951 | MSTHT_0563 | Homoserine dehydrogenase. | LL-diaminopimelate aminotransferase, methanococcal. | 0.468 |
AKB12709.1 | AKB13670.1 | MSTHT_0951 | MSTHT_1912 | Homoserine dehydrogenase. | Aspartokinase; Belongs to the aspartokinase family. | 0.991 |
AKB12709.1 | AKB13908.1 | MSTHT_0951 | MSTHT_2150 | Homoserine dehydrogenase. | Aspartate-semialdehyde dehydrogenase. | 0.989 |
AKB12709.1 | AKB14136.1 | MSTHT_0951 | MSTHT_2378 | Homoserine dehydrogenase. | Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. | 0.465 |
AKB12709.1 | dapA | MSTHT_0951 | MSTHT_1670 | Homoserine dehydrogenase. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.953 |
AKB12709.1 | dapB | MSTHT_0951 | MSTHT_1669 | Homoserine dehydrogenase. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.683 |
AKB12709.1 | hacB | MSTHT_0951 | MSTHT_2374 | Homoserine dehydrogenase. | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] | 0.400 |
AKB12709.1 | leuC-2 | MSTHT_0951 | MSTHT_2523 | Homoserine dehydrogenase. | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.440 |
AKB13670.1 | AKB12190.1 | MSTHT_1912 | MSTHT_0432 | Aspartokinase; Belongs to the aspartokinase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.487 |