node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKB12839.1 | AKB13262.1 | MSTHT_1081 | MSTHT_1504 | Phosphoribosylglycinamide formyltransferase. | IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.999 |
AKB12839.1 | folD | MSTHT_1081 | MSTHT_1083 | Phosphoribosylglycinamide formyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.981 |
AKB12839.1 | glyA | MSTHT_1081 | MSTHT_1082 | Phosphoribosylglycinamide formyltransferase. | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.973 |
AKB12839.1 | thyA | MSTHT_1081 | MSTHT_1647 | Phosphoribosylglycinamide formyltransferase. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.471 |
AKB12844.1 | folD | MSTHT_1086 | MSTHT_1083 | 5,10-methylenetetrahydrofolate reductase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
AKB12844.1 | glyA | MSTHT_1086 | MSTHT_1082 | 5,10-methylenetetrahydrofolate reductase. | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
AKB12844.1 | thyA | MSTHT_1086 | MSTHT_1647 | 5,10-methylenetetrahydrofolate reductase. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.922 |
AKB13262.1 | AKB12839.1 | MSTHT_1504 | MSTHT_1081 | IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | Phosphoribosylglycinamide formyltransferase. | 0.999 |
AKB13262.1 | folD | MSTHT_1504 | MSTHT_1083 | IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.990 |
AKB13262.1 | glyA | MSTHT_1504 | MSTHT_1082 | IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
AKB13262.1 | thyA | MSTHT_1504 | MSTHT_1647 | IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.593 |
folD | AKB12839.1 | MSTHT_1083 | MSTHT_1081 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase. | 0.981 |
folD | AKB12844.1 | MSTHT_1083 | MSTHT_1086 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase. | 0.932 |
folD | AKB13262.1 | MSTHT_1083 | MSTHT_1504 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.990 |
folD | glyA | MSTHT_1083 | MSTHT_1082 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
folD | thyA | MSTHT_1083 | MSTHT_1647 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.954 |
glyA | AKB12839.1 | MSTHT_1082 | MSTHT_1081 | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylglycinamide formyltransferase. | 0.973 |
glyA | AKB12844.1 | MSTHT_1082 | MSTHT_1086 | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5,10-methylenetetrahydrofolate reductase. | 0.944 |
glyA | AKB13262.1 | MSTHT_1082 | MSTHT_1504 | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | IMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.998 |
glyA | folD | MSTHT_1082 | MSTHT_1083 | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.996 |