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| | AKB11761.1 | Formaldehyde activating enzyme. (160 aa) |
| | AKB11775.1 | Tetrahydromethanopterin S-methyltransferase subunit H. (310 aa) |
| | AKB11776.1 | Tetrahydromethanopterin S-methyltransferase subunit A 1. (197 aa) |
| | AKB11840.1 | Methylcobalamin:coenzyme M methyltransferase, methanol-specific. (344 aa) |
| | AKB11841.1 | Methanol:corrinoid methyltransferase. (461 aa) |
| | AKB11842.1 | Methanol methyltransferase corrinoid protein. (255 aa) |
| | AKB11871.1 | Sulfopyruvate decarboxylase - beta subunit. (384 aa) |
| | AKB11885.1 | CO dehydrogenase iron-sulfur protein CooF. (165 aa) |
| | AKB11886.1 | Carbon monoxide dehydrogenase CooS subunit. (637 aa) |
| | AKB11942.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (803 aa) |
| | cofG | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil; Belongs to the radical SAM superfamily. CofG family. (290 aa) |
| | cofH | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (375 aa) |
| | cofH-2 | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (385 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (208 aa) |
| | AKB11983.1 | COG1821 family protein. (319 aa) |
| | AKB11984.1 | Putative H4MPT-linked C1 transfer pathway protein. (324 aa) |
| | AKB11985.1 | Delta 1-pyrroline-5-carboxylate synthetase. (219 aa) |
| | AKB12129.1 | Formylmethanofuran dehydrogenase subunit D. (132 aa) |
| | AKB12130.1 | Formylmethanofuran dehydrogenase subunit B. (414 aa) |
| | AKB12131.1 | Acetyl-CoA decarbonylase/synthase complex subunit gamma 1. (154 aa) |
| | AKB12133.1 | CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (798 aa) |
| | AKB12134.1 | Hypothetical protein. (483 aa) |
| | AKB12190.1 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. (405 aa) |
| | mch | N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (321 aa) |
| | AKB12247.1 | Dimethylamine:corrinoid methyltransferase; Pyrrolysine-containing. (467 aa) |
| | AKB12248.1 | Dimethylamine methyltransferase corrinoid protein. (216 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | ppcA | Phosphoenolpyruvate carboxylase, archaeal; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (526 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (238 aa) |
| | AKB12515.1 | FmdE, Molybdenum formylmethanofuran dehydrogenase operon. (113 aa) |
| | AKB12519.1 | Pyruvate:ferredoxin oxidoreductase, beta subunit. (296 aa) |
| | AKB12585.1 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (561 aa) |
| | AKB12596.1 | 6-phospho-3-hexuloisomerase. (210 aa) |
| | AKB12676.1 | N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit A. (182 aa) |
| | AKB12795.1 | Phosphate acetyltransferase. (333 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (408 aa) |
| | pfkC | ADP-dependent phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (490 aa) |
| | AKB12816.1 | ADP-dependent glucokinase. (466 aa) |
| | glyA | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | AKB12867.1 | Fructose-1,6-bisphosphatase, GlpX type. (385 aa) |
| | AKB12967.1 | Methylcobamide:CoM methyltransferase MtaA. (341 aa) |
| | AKB13027.1 | Formylmethanofuran dehydrogenase (tungsten) subunit D. (127 aa) |
| | AKB13028.1 | Formylmethanofuran dehydrogenase subunit B. (441 aa) |
| | AKB13029.1 | Formylmethanofuran dehydrogenase subunit A. (572 aa) |
| | AKB13030.1 | Formylmethanofuran dehydrogenase subunit C. (252 aa) |
| | AKB13041.1 | Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (307 aa) |
| | AKB13118.1 | Dimethylamine methyltransferase corrinoid protein. (220 aa) |
| | AKB13119.1 | Dimethylamine:corrinoid methyltransferase; Pyrrolysine-containing. (468 aa) |
| | AKB13120.1 | Trimethylamine:corrinoid methyltransferase; Pyrrolysine-containing; Belongs to the trimethylamine methyltransferase family. (495 aa) |
| | AKB13121.1 | Trimethylamine methyltransferase corrinoid protein. (217 aa) |
| | cofD | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (309 aa) |
| | AKB13174.1 | Coenzyme F420 hydrogenase subunit gamma. (253 aa) |
| | AKB13175.1 | Hydrogenase 1 maturation protease. (156 aa) |
| | AKB13176.1 | Coenzyme F420 hydrogenase subunit alpha; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (456 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (515 aa) |
| | AKB13280.1 | Methyl coenzyme M reductase system component A2. (537 aa) |
| | AKB13305.1 | Putative ABC transporter ATP-binding protein. (584 aa) |
| | AKB13324.1 | Coenzyme F420 hydrogenase subunit beta. (347 aa) |
| | AKB13330.1 | CoB--CoM heterodisulfide reductase subunit C. (161 aa) |
| | AKB13331.1 | CoB--CoM heterodisulfide reductase subunit B. (300 aa) |
| | AKB13398.1 | Methyl coenzyme M reductase beta subunit. (434 aa) |
| | AKB13399.1 | Methyl coenzyme M reductase operon protein D. (171 aa) |
| | AKB13400.1 | Methyl coenzyme M reductase operon protein C. (206 aa) |
| | AKB13401.1 | Methyl coenzyme M reductase gamma subunit. (248 aa) |
| | AKB13402.1 | Methyl coenzyme M reductase alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (571 aa) |
| | AKB13422.1 | D-arabino-3-hexulose 6-phosphate formaldehyde lyase; Hypothetical protein with distant similarity to Ribonuclease E inhibitor RraA (former MenG). (383 aa) |
| | mfnB | Duf556 family protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (234 aa) |
| | mtd | F420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa) |
| | AKB13482.1 | Phosphoserine phosphatase. (222 aa) |
| | AKB13508.1 | Methanol:corrinoid methyltransferase. (461 aa) |
| | AKB13509.1 | Methanol methyltransferase corrinoid protein. (258 aa) |
| | AKB13512.1 | Methylcobalamin:coenzyme M methyltransferase, methanol-specific. (339 aa) |
| | AKB13522.1 | FmdE, Molybdenum formylmethanofuran dehydrogenase operon. (189 aa) |
| | AKB13523.1 | Polyferredoxin protein MvhB. (346 aa) |
| | AKB13524.1 | Formylmethanofuran dehydrogenase subunit A. (584 aa) |
| | AKB13525.1 | Formylmethanofuran dehydrogenase (molybdenum) subunit C. (286 aa) |
| | AKB13526.1 | Formylmethanofuran dehydrogenase (molybdenum) subunit D. (129 aa) |
| | AKB13527.1 | Formylmethanofuran dehydrogenase (molybdenum) subunit B. (433 aa) |
| | aroA-2 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa) |
| | fae-hps | Formaldehyde activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (392 aa) |
| | mfnA | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (401 aa) |
| | ftr | Formylmethanofuran--tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (297 aa) |
| | AKB13600.1 | Pyruvate:ferredoxin oxidoreductase, beta subunit. (296 aa) |
| | AKB13601.1 | Pyruvate:ferredoxin oxidoreductase, alpha subunit. (402 aa) |
| | AKB13602.1 | Pyruvate:ferredoxin oxidoreductase, delta subunit. (111 aa) |
| | AKB13603.1 | Pyruvate:ferredoxin oxidoreductase, gamma subunit. (182 aa) |
| | apgM | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (398 aa) |
| | cofE | Coenzyme F420:L-glutamate ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (254 aa) |
| | AKB13684.1 | Monomethylamine:corrinoid methyltransferase; Pyrrolysine-containing. (458 aa) |
| | AKB13685.1 | Monomethylamine methyltransferase corrinoid protein. (217 aa) |
| | AKB13686.1 | Methylcobalamin:coenzyme M methyltransferase, methylamine-specific. (339 aa) |
| | mtrE | N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (304 aa) |
| | mtrD | N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (250 aa) |
| | mtrC | N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (267 aa) |
| | mtrB | N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (108 aa) |
| | mtrA | N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (241 aa) |
| | mtrF | N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit F; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (71 aa) |
| | mtrG | N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (72 aa) |
| | mtrH | N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (316 aa) |
| | AKB13820.1 | Dimethylamine methyltransferase corrinoid protein. (208 aa) |
| | AKB13822.1 | Trimethylamine methyltransferase corrinoid protein. (217 aa) |
| | AKB13825.1 | Dimethylamine:corrinoid methyltransferase; Pyrrolysine-containing. (467 aa) |
| | AKB13865.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (523 aa) |
| | AKB13894.1 | Methanol methyltransferase corrinoid protein. (258 aa) |
| | AKB13895.1 | Methanol:corrinoid methyltransferase. (461 aa) |
| | aroA-3 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (286 aa) |
| | AKB13917.1 | FmdE, Molybdenum formylmethanofuran dehydrogenase operon. (194 aa) |
| | AKB13966.1 | Valine--pyruvate aminotransferase. (394 aa) |
| | AKB13988.1 | Ferredoxin. (87 aa) |
| | hdrE | CoB--CoM heterodisulfide reductase 2 subunit E; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrE may be responsible for anchoring the complex to the membrane. Electrons probably transfer from phenazine to the high potential 4Fe cluster in HdrD subunit, then to the low potential heme in HdrE subunit and finally to CoM-S-S-CoB. (260 aa) |
| | hdrD | CoB--CoM heterodisulfide reductase 2 iron-sulfur subunit D; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Electrons probably transfer from phenazine to the high potential 4Fe cluster in HdrD subunit, then to the low potential heme in HdrE subunit and finally to CoM-S-S-CoB. (409 aa) |
| | AKB14073.1 | Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase. (307 aa) |
| | cdhE | 5-tetrahydromethanopterin:corrinoid iron-sulfur protein methyltransferase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. (469 aa) |
| | cdhD | CO dehydrogenase/acetyl-CoA synthase subunit delta, corrinoid iron-sulfur subcomplex small subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex. (437 aa) |
| | cdhC | CO dehydrogenase/acetyl-CoA synthase subunit beta, acetyl-CoA synthase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron- sulfur protein (the gamma-delta complex). (472 aa) |
| | cdhB | CO dehydrogenase/acetyl-CoA synthase subunit epsilon, CO dehydrogenase subcomplex; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD- mediated CO oxidation. (170 aa) |
| | cdhA | CO dehydrogenase/acetyl-CoA synthase subunit alpha, CO dehydrogenase subcomplex; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (803 aa) |
| | hacB | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] (166 aa) |
| | AKB14136.1 | Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. (330 aa) |
| | mer | 5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (328 aa) |
| | AKB14277.1 | CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (803 aa) |
| | AKB14278.1 | CoB--CoM heterodisulfide reductase subunit C. (236 aa) |
| | AKB14279.1 | CoB--CoM heterodisulfide reductase subunit B. (314 aa) |
| | leuC-2 | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa) |
