STRINGSTRING
ilvD ilvD AKB12619.1 AKB12619.1 AKB12745.1 AKB12745.1 AKB12746.1 AKB12746.1 AKB12747.1 AKB12747.1 coaD coaD ilvE ilvE mfnA mfnA AKB14110.1 AKB14110.1 AKB14111.1 AKB14111.1 ilvC ilvC AKB14155.1 AKB14155.1 AKB14176.1 AKB14176.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa)
AKB12619.1Acetolactate synthase; Belongs to the TPP enzyme family. (544 aa)
AKB12745.1Phosphopantothenoylcysteine synthetase. (455 aa)
AKB12746.1Pantoate kinase, archaeal. (337 aa)
AKB12747.1Phosphopantothenate synthetase, archaeal. (253 aa)
coaDPhosphopantetheine adenylyltransferase, type II eukaryotic; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (156 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa)
mfnAL-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (401 aa)
AKB14110.1Acetolactate synthase large subunit. (587 aa)
AKB14111.1Acetolactate synthase small subunit. (161 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa)
AKB14155.1Hypothetical protein. (228 aa)
AKB14176.1Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (195 aa)
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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