node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKB12619.1 | AKB14110.1 | MSTHT_0861 | MSTHT_2352 | Acetolactate synthase; Belongs to the TPP enzyme family. | Acetolactate synthase large subunit. | 0.913 |
AKB12619.1 | AKB14111.1 | MSTHT_0861 | MSTHT_2353 | Acetolactate synthase; Belongs to the TPP enzyme family. | Acetolactate synthase small subunit. | 0.995 |
AKB12619.1 | ilvC | MSTHT_0861 | MSTHT_2354 | Acetolactate synthase; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.972 |
AKB12619.1 | ilvD | MSTHT_0861 | MSTHT_0014 | Acetolactate synthase; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.761 |
AKB12619.1 | ilvE | MSTHT_0861 | MSTHT_1624 | Acetolactate synthase; Belongs to the TPP enzyme family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.797 |
AKB12745.1 | AKB12746.1 | MSTHT_0987 | MSTHT_0988 | Phosphopantothenoylcysteine synthetase. | Pantoate kinase, archaeal. | 0.861 |
AKB12745.1 | AKB12747.1 | MSTHT_0987 | MSTHT_0989 | Phosphopantothenoylcysteine synthetase. | Phosphopantothenate synthetase, archaeal. | 0.973 |
AKB12745.1 | coaD | MSTHT_0987 | MSTHT_1070 | Phosphopantothenoylcysteine synthetase. | Phosphopantetheine adenylyltransferase, type II eukaryotic; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. | 0.913 |
AKB12746.1 | AKB12745.1 | MSTHT_0988 | MSTHT_0987 | Pantoate kinase, archaeal. | Phosphopantothenoylcysteine synthetase. | 0.861 |
AKB12746.1 | AKB12747.1 | MSTHT_0988 | MSTHT_0989 | Pantoate kinase, archaeal. | Phosphopantothenate synthetase, archaeal. | 0.989 |
AKB12746.1 | AKB14176.1 | MSTHT_0988 | MSTHT_2418 | Pantoate kinase, archaeal. | Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.603 |
AKB12747.1 | AKB12745.1 | MSTHT_0989 | MSTHT_0987 | Phosphopantothenate synthetase, archaeal. | Phosphopantothenoylcysteine synthetase. | 0.973 |
AKB12747.1 | AKB12746.1 | MSTHT_0989 | MSTHT_0988 | Phosphopantothenate synthetase, archaeal. | Pantoate kinase, archaeal. | 0.989 |
AKB12747.1 | AKB14176.1 | MSTHT_0989 | MSTHT_2418 | Phosphopantothenate synthetase, archaeal. | Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.473 |
AKB12747.1 | mfnA | MSTHT_0989 | MSTHT_1822 | Phosphopantothenate synthetase, archaeal. | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. | 0.932 |
AKB14110.1 | AKB12619.1 | MSTHT_2352 | MSTHT_0861 | Acetolactate synthase large subunit. | Acetolactate synthase; Belongs to the TPP enzyme family. | 0.913 |
AKB14110.1 | AKB14111.1 | MSTHT_2352 | MSTHT_2353 | Acetolactate synthase large subunit. | Acetolactate synthase small subunit. | 0.999 |
AKB14110.1 | ilvC | MSTHT_2352 | MSTHT_2354 | Acetolactate synthase large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.991 |
AKB14110.1 | ilvD | MSTHT_2352 | MSTHT_0014 | Acetolactate synthase large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.954 |
AKB14110.1 | ilvE | MSTHT_2352 | MSTHT_1624 | Acetolactate synthase large subunit. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.797 |