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cobQ cobQ AKB13006.1 AKB13006.1 AKB13011.1 AKB13011.1 AKB13022.1 AKB13022.1 AKB13110.1 AKB13110.1 cobD cobD cobS cobS AKB13114.1 AKB13114.1 AKB13338.1 AKB13338.1 AKB13339.1 AKB13339.1 AKB13340.1 AKB13340.1 AKB13341.1 AKB13341.1 AKB13342.1 AKB13342.1 AKB13343.1 AKB13343.1 cbiT cbiT AKB13548.1 AKB13548.1 cbiA cbiA AKB13814.1 AKB13814.1 cbiD cbiD AKB13845.1 AKB13845.1 AKB13846.1 AKB13846.1 AKB13847.1 AKB13847.1 AKB13848.1 AKB13848.1 hemA hemA AKB13850.1 AKB13850.1 hemL hemL hemC hemC gltX gltX AKB13919.1 AKB13919.1 cbiX cbiX AKB14207.1 AKB14207.1 AKB14208.1 AKB14208.1 AKB14209.1 AKB14209.1 cbiA-2 cbiA-2 AKB14292.1 AKB14292.1 AKB14293.1 AKB14293.1 AKB14294.1 AKB14294.1
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (485 aa)
AKB13006.1ChlD component of cobalt chelatase involved in B12 biosynthesis. (679 aa)
AKB13011.1CobN component of cobalt chelatase involved in B12 biosynthesis. (1328 aa)
AKB13022.1Methylcobamide:CoM methyltransferase MtbA. (348 aa)
AKB13110.1L-threonine 3-O-phosphate decarboxylase. (483 aa)
cobDAdenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (328 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (280 aa)
AKB13114.1Putative adenosylcobinamide-phosphate guanylyltransferase CobY. (201 aa)
AKB13338.1Cobalt-precorrin-8x methylmutase. (243 aa)
AKB13339.1Cobalt-precorrin-3b C17-methyltransferase. (266 aa)
AKB13340.1Cobalamin biosynthesis protein CbiG. (117 aa)
AKB13341.1Cobalamin biosynthesis protein CbiG. (133 aa)
AKB13342.1Cobalt-precorrin-4 C11-methyltransferase. (242 aa)
AKB13343.1Cobalt-precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (202 aa)
cbiTCobalt-precorrin-6y C15-methyltransferase (decarboxylating); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (184 aa)
AKB13548.1Bacterioferritin. (156 aa)
cbiACobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (439 aa)
AKB13814.1Cobalt-precorrin-6y C5-methyltransferase. (195 aa)
cbiDCobalt-precorrin-6 synthase, anaerobic; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (339 aa)
AKB13845.1Radical SAM domain heme biosynthesis protein. (349 aa)
AKB13846.1Heme biosynthesis protein related to NirD and NirG. (182 aa)
AKB13847.1Heme biosynthesis protein related to NirL and NirH. (152 aa)
AKB13848.1Siroheme synthase; Precorrin-2 oxidase; Sirohydrochlorin ferrochelatase. (224 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (505 aa)
AKB13850.1Porphobilinogen synthase; Belongs to the ALAD family. (315 aa)
hemLGlutamate-1-semialdehyde aminotransferase. (424 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (316 aa)
gltXGlutamyl-tRNA synthetase / Glutamyl-tRNA(Gln) synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (571 aa)
AKB13919.1CobN-like chelatase BtuS for metalloporphyrine salvage. (1446 aa)
cbiXSirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (130 aa)
AKB14207.1UDP-N-acetylmuramoylalanine--D-glutamate ligase. (475 aa)
AKB14208.1Nitrogenase-related protein. (370 aa)
AKB14209.1Nitrogenase reductase-like protein. (265 aa)
cbiA-2Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (495 aa)
AKB14292.1Radical SAM domain protein. (399 aa)
AKB14293.1Uroporphyrinogen-III synthase. (272 aa)
AKB14294.1Uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. (255 aa)
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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