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ilvD ilvD AKB11785.1 AKB11785.1 AKB12190.1 AKB12190.1 leuC leuC AKB12595.1 AKB12595.1 AKB12619.1 AKB12619.1 argC argC argJ argJ AKB13345.1 AKB13345.1 AKB13346.1 AKB13346.1 AKB13375.1 AKB13375.1 ilvE ilvE argB argB AKB13551.1 AKB13551.1 argD argD AKB13670.1 AKB13670.1 leuD leuD AKB13795.1 AKB13795.1 AKB13796.1 AKB13796.1 AKB13804.1 AKB13804.1 AKB13908.1 AKB13908.1 cimA cimA AKB14110.1 AKB14110.1 AKB14111.1 AKB14111.1 ilvC ilvC hacB hacB AKB14136.1 AKB14136.1 leuC-2 leuC-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa)
AKB11785.1Aspartate aminotransferase. (380 aa)
AKB12190.1Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. (405 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (431 aa)
AKB12595.1Biosynthetic Aromatic amino acid aminotransferase alpha / Aspartate aminotransferase. (370 aa)
AKB12619.1Acetolactate synthase; Belongs to the TPP enzyme family. (544 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (337 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (395 aa)
AKB13345.12-isopropylmalate synthase. (442 aa)
AKB13346.13-isopropylmalate dehydrogenase. (342 aa)
AKB13375.1GCN5-related N-acetyltransferase. (151 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa)
AKB13551.12-isopropylmalate synthase. (430 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa)
AKB13670.1Aspartokinase; Belongs to the aspartokinase family. (472 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa)
AKB13795.1Aconitate hydratase. (934 aa)
AKB13796.1Citrate synthase (si). (355 aa)
AKB13804.1N-acetylglutamate synthase. (146 aa)
AKB13908.1Aspartate-semialdehyde dehydrogenase. (342 aa)
cimA(R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (483 aa)
AKB14110.1Acetolactate synthase large subunit. (587 aa)
AKB14111.1Acetolactate synthase small subunit. (161 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa)
hacBCoenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] (166 aa)
AKB14136.1Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. (330 aa)
leuC-2Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa)
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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