STRINGSTRING
OCC_00332 OCC_00332 OCC_00337 OCC_00337 OCC_00342 OCC_00342 OCC_00347 OCC_00347 OCC_00352 OCC_00352 OCC_00357 OCC_00357 OCC_00582 OCC_00582 OCC_01039 OCC_01039 OCC_01109 OCC_01109 guaAA guaAA guaAB guaAB guaB guaB purA purA gcvT gcvT OCC_03763 OCC_03763 OCC_04093 OCC_04093 OCC_04098 OCC_04098 tdh tdh glyA glyA OCC_05516 OCC_05516 OCC_06428 OCC_06428 purC purC purL purL purS purS purD purD purE purE purT purT purM purM purC-2 purC-2 purF purF OCC_06861 OCC_06861 OCC_07084 OCC_07084 OCC_07089 OCC_07089 gcvPB gcvPB gcvPA gcvPA OCC_07341 OCC_07341 OCC_08410 OCC_08410 OCC_09114 OCC_09114 gcvH gcvH glmS glmS OCC_09993 OCC_09993 pyrD pyrD OCC_10003 OCC_10003 OCC_10008 OCC_10008 pyrI pyrI pyrB pyrB pyrE pyrE mfnA mfnA OCC_10209 OCC_10209 OCC_10945 OCC_10945 OCC_11152 OCC_11152 OCC_11814 OCC_11814 OCC_11984 OCC_11984 OCC_12321 OCC_12321 OCC_12356 OCC_12356 OCC_12591 OCC_12591 OCC_12941 OCC_12941 OCC_13515 OCC_13515 OCC_13795 OCC_13795 OCC_13800 OCC_13800
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OCC_00332Sarcosine oxidase subunit beta; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (387 aa)
OCC_00337D-nopaline dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (93 aa)
OCC_00342Polyferredoxin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (168 aa)
OCC_00347Sarcosine oxidase subunit alpha; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (477 aa)
OCC_00352Sarcosine oxidase subunit beta; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (379 aa)
OCC_00357D-nopaline dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (494 aa)
OCC_005824-aminobutyrate aminotransferase; Catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (447 aa)
OCC_01039Maleate cis-trans isomerase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (237 aa)
OCC_01109Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (450 aa)
guaAAGMP synthase; Catalyzes the synthesis of GMP from XMP. (188 aa)
guaABGMP synthase; Catalyzes the synthesis of GMP from XMP. (307 aa)
guaBInosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (483 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (339 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (397 aa)
OCC_03763Adenine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (237 aa)
OCC_04093ferredoxin--NADP reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (282 aa)
OCC_04098Dihydropyrimidine dehydrogenase subunit A; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (480 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (350 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
OCC_05516Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (364 aa)
OCC_06428Asparagine synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (480 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the SAICAR synthetase family. (219 aa)
purLPhosphoribosylglycinamide synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the tr [...] (712 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (81 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the GARS family. (431 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (143 aa)
purTPhosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (429 aa)
purMPhosphoribosylaminoimidazole synthetase; Phage-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
purC-2Phosphoribosylaminoimidazole-succinocarboxamide synthase; Phage-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (231 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (443 aa)
OCC_068612-amino-3-ketobutyrate CoA ligase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (395 aa)
OCC_07084ferredoxin--NADP reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (289 aa)
OCC_07089Dihydropyrimidine dehydrogenase subunit A; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (476 aa)
gcvPBGlycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (499 aa)
gcvPAGlycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (451 aa)
OCC_07341Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (186 aa)
OCC_084104-aminobutyrate aminotransferase; Catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (458 aa)
OCC_09114Apolipoprotein N- acyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (264 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (134 aa)
glmSGlucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (601 aa)
OCC_09993Orotidine 5-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (249 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (306 aa)
OCC_10003Dihydroorotate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (235 aa)
OCC_10008Dihydroorotase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (419 aa)
pyrIAspartate carbamoyltransferase; Involved in allosteric regulation of aspartate carbamoyltransferase. (150 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (306 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (190 aa)
mfnAL-tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (385 aa)
OCC_10209Asparaginase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (345 aa)
OCC_109454-aminobutyrate aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
OCC_11152Aspartate racemase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (225 aa)
OCC_11814Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (352 aa)
OCC_11984Aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (321 aa)
OCC_12321Glutamate synthase; Unknown function; probable involvement in glutamate synthesis; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (351 aa)
OCC_12356Asparaginase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (305 aa)
OCC_12591Uracil permease; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (427 aa)
OCC_12941Glutamine synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glutamine synthetase family. (440 aa)
OCC_13515Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (156 aa)
OCC_13795Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (121 aa)
OCC_13800Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (87 aa)
Your Current Organism:
Thermococcus litoralis
NCBI taxonomy Id: 523849
Other names: T. litoralis DSM 5473, Thermococcus litoralis ATCC 51850, Thermococcus litoralis DSM 5473, Thermococcus litoralis JCM 8560, Thermococcus litoralis NS-C, Thermococcus litoralis str. DSM 5473, Thermococcus litoralis strain DSM 5473
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