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OCC_11177 OCC_11177 OCC_00272 OCC_00272 queC queC tiaS tiaS guaAA guaAA guaAB guaAB OCC_01709 OCC_01709 purA purA OCC_04345 OCC_04345 gatD gatD gatE gatE OCC_05179 OCC_05179 purP purP purC purC OCC_06571 OCC_06571 purL purL purS purS OCC_06656 OCC_06656 purD purD purM purM purC-2 purC-2 OCC_06996 OCC_06996 pyrG pyrG OCC_09299 OCC_09299 OCC_09461 OCC_09461 OCC_09586 OCC_09586 OCC_11964 OCC_11964 OCC_12736 OCC_12736 OCC_12941 OCC_12941 nadE nadE OCC_13795 OCC_13795 OCC_13800 OCC_13800
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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OCC_11177Phosphopantothenoylcysteine decarboxylase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (405 aa)
OCC_00272Dihydropteroate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (274 aa)
queC7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (239 aa)
tiaStRNA(Ile2) 2-agmatinylcytidine synthetase; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. (427 aa)
guaAAGMP synthase; Catalyzes the synthesis of GMP from XMP. (188 aa)
guaABGMP synthase; Catalyzes the synthesis of GMP from XMP. (307 aa)
OCC_01709Lipoate-protein ligase A; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (95 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (339 aa)
OCC_04345Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (262 aa)
gatDglutamyl-tRNA(Gln) amidotransferase; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (439 aa)
gatEglutamyl-tRNA(Gln) amidotransferase; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (627 aa)
OCC_05179Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (203 aa)
purP5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (333 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the SAICAR synthetase family. (219 aa)
OCC_065715-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (310 aa)
purLPhosphoribosylglycinamide synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the tr [...] (712 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (81 aa)
OCC_066565-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (380 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the GARS family. (431 aa)
purMPhosphoribosylaminoimidazole synthetase; Phage-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
purC-2Phosphoribosylaminoimidazole-succinocarboxamide synthase; Phage-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (231 aa)
OCC_06996Nicotinate phosphoribosyltransferase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (390 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (531 aa)
OCC_09299Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (226 aa)
OCC_09461Polyketide cyclase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (139 aa)
OCC_09586Biotin-protein ligase; Catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (248 aa)
OCC_11964ATP pyrophosphatase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (214 aa)
OCC_12736Biotin--[acetyl CoA carboxylase] ligase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (247 aa)
OCC_12941Glutamine synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glutamine synthetase family. (440 aa)
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (254 aa)
OCC_13795Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (121 aa)
OCC_13800Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (87 aa)
Your Current Organism:
Thermococcus litoralis
NCBI taxonomy Id: 523849
Other names: T. litoralis DSM 5473, Thermococcus litoralis ATCC 51850, Thermococcus litoralis DSM 5473, Thermococcus litoralis JCM 8560, Thermococcus litoralis NS-C, Thermococcus litoralis str. DSM 5473, Thermococcus litoralis strain DSM 5473
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