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hisF hisF hisI hisI Sdel_0208 Sdel_0208 Sdel_0216 Sdel_0216 hisC hisC Sdel_0230 Sdel_0230 trpA trpA aroE aroE Sdel_0572 Sdel_0572 hisG hisG aroA aroA hisB hisB trpB trpB trpD trpD aroB aroB Sdel_1291 Sdel_1291 trpC trpC hisD hisD trpF trpF Sdel_1638 Sdel_1638 Sdel_1681 Sdel_1681 trpB-2 trpB-2 aroK aroK hisA hisA hisH hisH aroC aroC
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisITIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: nis:NIS_1544 histidine biosynthesis bifunctional protein HisI; In the N-terminal section; belongs to the PRA-CH family. (227 aa)
Sdel_0208KEGG: abu:Abu_0221 3-phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD- superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. (206 aa)
Sdel_0216TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; Chorismate mutase; KEGG: cff:CFF8240_0269 chorismate mutase/prephenate dehydratase. (355 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: wsu:WS2000 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa)
Sdel_0230PFAM: Prephenate dehydrogenase; KEGG: nis:NIS_0406 prephenate dehydrogenase. (275 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (246 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (263 aa)
Sdel_0572Anthranilate synthase; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; KEGG: tdn:Suden_1277 anthranilate synthase. (470 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (203 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: abu:Abu_0977 imidazoleglycerol-phosphate dehydratase. (190 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (401 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (327 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (348 aa)
Sdel_1291PFAM: aminotransferase class I and II; KEGG: nis:NIS_0815 aspartate aminotransferase. (389 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: sun:SUN_1695 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (262 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: nis:NIS_0321 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (195 aa)
Sdel_1638PFAM: Chorismate binding-like; KEGG: nis:NIS_0375 para-aminobenzoate synthase component I. (320 aa)
Sdel_1681TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: abu:Abu_2004 anthranilate synthase component II. (189 aa)
trpB-2Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa)
hisAKEGG: nis:NIS_1411 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. (240 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (203 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (358 aa)
Your Current Organism:
Sulfurospirillum deleyianum
NCBI taxonomy Id: 525898
Other names: S. deleyianum DSM 6946, Sulfurospirillum deleyianum DSM 6946, Sulfurospirillum deleyianum str. DSM 6946, Sulfurospirillum deleyianum strain DSM 6946
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