STRINGSTRING
topA topA Sdel_2161 Sdel_2161 Sdel_1410 Sdel_1410 ruvA ruvA Sdel_0951 Sdel_0951 Sdel_0852 Sdel_0852 Sdel_1231 Sdel_1231 Sdel_0766 Sdel_0766 ruvB ruvB gyrA gyrA Sdel_0066 Sdel_0066 gyrB gyrB Sdel_0769 Sdel_0769 Sdel_1633 Sdel_1633 Sdel_1595 Sdel_1595 Sdel_1535 Sdel_1535 Sdel_1416 Sdel_1416 Sdel_0767 Sdel_0767 priA priA Sdel_1910 Sdel_1910
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (694 aa)
Sdel_2161TIGRFAM: Mg chelatase, subunit ChlI; PFAM: magnesium chelatase ChlI subunit; KEGG: ccv:CCV52592_1502 putative Mg chelatase-like protein. (511 aa)
Sdel_1410PFAM: UvrD/REP helicase; KEGG: ccv:CCV52592_1083 acyl carrier protein. (676 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (186 aa)
Sdel_0951KEGG: sun:SUN_0733 hypothetical protein. (492 aa)
Sdel_0852PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; KEGG: sun:SUN_1915 ATP-dependent DNA helicase RecG. (614 aa)
Sdel_1231PFAM: Abortive phage infection; KEGG: nmu:Nmul_A2605 hypothetical protein. (567 aa)
Sdel_0766PFAM: Relaxase/mobilization nuclease family protein; KEGG: sun:SUN_2446 DNA relaxase TraI. (521 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (340 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (846 aa)
Sdel_0066PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: cco:CCC13826_1825 recombination factor protein RarA. (396 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (770 aa)
Sdel_0769Hypothetical protein. (105 aa)
Sdel_1633PFAM: UvrD/REP helicase; KEGG: nis:NIS_1473 ATP-dependent DNA helicase UvrD. (681 aa)
Sdel_1595Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (476 aa)
Sdel_1535KEGG: sun:SUN_2266 ATP-dependent DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP- dependent DNA helicase, RecQ family; PFAM: HRDC domain protein; DEAD/DEAH box helicase domain protein; RQC domain; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; HRDC domain protein. (596 aa)
Sdel_1416KEGG: sun:SUN_0982 hypothetical protein. (442 aa)
Sdel_0767Hypothetical protein. (185 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (611 aa)
Sdel_1910PFAM: UvrD/REP helicase; KEGG: tdn:Suden_0090 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (907 aa)
Your Current Organism:
Sulfurospirillum deleyianum
NCBI taxonomy Id: 525898
Other names: S. deleyianum DSM 6946, Sulfurospirillum deleyianum DSM 6946, Sulfurospirillum deleyianum str. DSM 6946, Sulfurospirillum deleyianum strain DSM 6946
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