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| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (355 aa) |
| | thyX | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (204 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (131 aa) |
| | Sdel_0044 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: sun:SUN_1936 UTP--glucose-1-phosphate uridylyltransferase. (289 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (546 aa) |
| | Sdel_0049 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (340 aa) |
| | Sdel_0055 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; KEGG: wsu:WS0416 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (442 aa) |
| | Sdel_0060 | KEGG: tdn:Suden_2092 hypothetical protein. (182 aa) |
| | Sdel_0064 | KpsF/GutQ family protein; KEGG: nis:NIS_0063 arabinose-5-phosphate isomerase; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. (321 aa) |
| | Sdel_0069 | PFAM: protein of unknown function DUF218; KEGG: nam:NAMH_1317 hypothetical protein. (261 aa) |
| | purM | KEGG: nam:NAMH_0144 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (331 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (201 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (445 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (362 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (149 aa) |
| | lpxA | acyl-(acyl-carrier-protein)--UDP-N-acetylglucosa mineO-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (263 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl- phosphate synthetase large chain domain protein; KEGG: ccv:CCV52592_0870 carbamoyl phosphate synthase large subunit; Belongs to the CarB family. (1085 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (263 aa) |
| | Sdel_0200 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (343 aa) |
| | Sdel_0203 | KEGG: cla:Cla_1371 hypothetical protein. (246 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (331 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (610 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa) |
| | lpxC | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (294 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (202 aa) |
| | Sdel_0260 | KEGG: ccv:CCV52592_0132 hypothetical protein. (115 aa) |
| | Sdel_0263 | PFAM: glycosyl transferase family 9; KEGG: tdn:Suden_0585 heptosyltransferase-like protein. (320 aa) |
| | Sdel_0301 | PFAM: glycosyl transferase family 2; KEGG: pla:Plav_3309 glycosyl transferase family protein. (309 aa) |
| | Sdel_0302 | PFAM: WbqC-like family protein; KEGG: mmw:Mmwyl1_0831 WbqC-like family protein. (230 aa) |
| | Sdel_0304 | KEGG: nmu:Nmul_A0286 hypothetical protein. (120 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (309 aa) |
| | pyrB | KEGG: cha:CHAB381_0964 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa) |
| | Sdel_0336 | Hypothetical protein; KEGG: cti:RALTA_B1244 putative aspartate/glutamate/hydantoin racemase. (278 aa) |
| | Sdel_0370 | PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: ccv:CCV52592_0922 putative periplasmic protein. (365 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: cjr:CJE1589 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | Sdel_0423 | PFAM: triosephosphate isomerase; KEGG: abu:Abu_2134 triosephosphate isomerase. (237 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (482 aa) |
| | Sdel_0492 | UDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (437 aa) |
| | Sdel_0501 | Pyruvate kinase; KEGG: cff:CFF8240_0630 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (481 aa) |
| | Sdel_0510 | PFAM: H+transporting two-sector ATPase B/B' subunit; KEGG: ccv:CCV52592_1733 F0F1 ATP synthase subunit B'; Belongs to the ATPase B chain family. (140 aa) |
| | atpF | H+transporting two-sector ATPase B/B' subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (171 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (176 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (501 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (294 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (465 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (131 aa) |
| | Sdel_0526 | Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (231 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa) |
| | coaX | Transcriptional activator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (207 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (511 aa) |
| | purD | KEGG: nis:NIS_1337 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP- grasp (A) domain; Phosphoribosylglycinamide synthetase, N- domain; Phosphoribosylglycinamide synthetase, C-domain; ATP-dependent carboxylate-amine ligase domain protein ATP- grasp; Belongs to the GARS family. (424 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (100 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (277 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa) |
| | Sdel_0647 | RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (718 aa) |
| | Sdel_0650 | KEGG: ccv:CCV52592_0486 N-acetylmuramoyl-L-alanine amidase domain-containing protein; PFAM: cell wall hydrolase/autolysin; SMART: cell wall hydrolase/autolysin. (525 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (190 aa) |
| | rlpA | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (264 aa) |
| | Sdel_0664 | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: nis:NIS_0778 YrbI family phosphatase. (165 aa) |
| | Sdel_0670 | KEGG: ccv:CCV52592_0450 penicillin-binding protein 2; TIGRFAM: penicillin-binding protein 2; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. (607 aa) |
| | Sdel_0672 | KEGG: sun:SUN_1127 hypothetical protein. (337 aa) |
| | Sdel_0678 | PFAM: Lytic transglycosylase catalytic; KEGG: cju:C8J_0790 soluble lytic murein transglycosylase, putative. (547 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (185 aa) |
| | Sdel_0958 | KEGG: abu:Abu_1070 deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; SMART: metal-dependent phosphohydrolase HD region. (480 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (404 aa) |
| | Sdel_1045 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (702 aa) |
| | ddl | D-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (344 aa) |
| | murJ | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (469 aa) |
| | Sdel_1056 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (355 aa) |
| | mltG | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (282 aa) |
| | pgi | PFAM: phosphoglucose isomerase (PGI); KEGG: sun:SUN_1935 glucose-6-phosphate isomerase; Belongs to the GPI family. (422 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (433 aa) |
| | Sdel_1124 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa) |
| | Sdel_1129 | PFAM: glycoside hydrolase family 3 domain protein; KEGG: cff:CFF8240_0777 glycosy hydrolase family protein. (345 aa) |
| | gpsA | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: abu:Abu_0029 NAD(P)H-dependent glycerol-3- phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (296 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (225 aa) |
| | Sdel_1191 | TIGRFAM: membrane lipoprotein lipid attachment site; KEGG: nis:NIS_1695 hypothetical protein. (207 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (373 aa) |
| | Sdel_1280 | PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; KEGG: wsu:WS0137 NCAIR mutase (PurE)-related protein. (248 aa) |
| | murA | UDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (422 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (194 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl) glucosamine N- acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (317 aa) |
| | Sdel_1339 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (358 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (312 aa) |
| | kdsB | 3-deoxy-D-manno- octulosonatecytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (237 aa) |
| | Sdel_1369 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; KEGG: cco:CCC13826_2025 bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (293 aa) |
| | purC | KEGG: cla:Cla_0709 phosphoribosylaminoimidazole- succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase. (237 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (81 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (223 aa) |
| | purH | KEGG: cco:CCC13826_1632 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. (510 aa) |
| | Sdel_1441 | PFAM: thioesterase superfamily protein; KEGG: wsu:WS1541 acyl-CoA hydrolase. (161 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (733 aa) |
| | Sdel_1454 | S-adenosylmethionine/tRNA-ribosyltransferase-iso merase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (308 aa) |
| | Sdel_1466 | PFAM: Phosphoglycerate mutase; KEGG: dat:HRM2_06990 putative molybdopterine- guanine dinucleotide biosynthesis protein MobA. (198 aa) |
| | Sdel_1475 | PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; ferredoxin; [2Fe-2S]-binding domain protein; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: sfu:Sfum_1310 aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding. (907 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (280 aa) |
| | acsA | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (648 aa) |
| | Sdel_1588 | UDP-sugar diphosphatase; PFAM: NUDIX hydrolase; KEGG: pin:Ping_3682 UDP-sugar diphosphatase. (189 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (354 aa) |
| | Sdel_1607 | KEGG: abu:Abu_0860 ribulose-phosphate 3-epimerase; TIGRFAM: ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (213 aa) |
| | Sdel_1648 | KEGG: cco:CCC13826_1432 hypothetical protein. (81 aa) |
| | Sdel_1652 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (391 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa) |
| | Sdel_1662 | TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin- binding protein transpeptidase; KEGG: cff:CFF8240_1032 penicillin-binding protein 1A (PBP-1a) (PBP1a). (641 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (342 aa) |
| | Sdel_1680 | KEGG: abu:Abu_2003 hypothetical protein. (395 aa) |
| | Sdel_1684 | PFAM: phosphoribosyltransferase; KEGG: cla:Cla_0429 nucleotide phosphoribosyltransferase, putative. (149 aa) |
| | glmS | Glucosamine/fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (603 aa) |
| | ispDF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (374 aa) |
| | Sdel_1720 | PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: wsu:WS0721 penicillin-binding protein; Belongs to the peptidase S11 family. (309 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (227 aa) |
| | kdsA | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: cjr:CJE0433 2-dehydro-3-deoxyphosphooctonate aldolase. (266 aa) |
| | Sdel_1767 | PFAM: Oligosaccharyl transferase STT3 subunit; KEGG: tdn:Suden_1474 oligosaccharyl transferase, STT3 subunit. (715 aa) |
| | Sdel_1768 | PFAM: lipopolysaccharide biosynthesis protein; KEGG: nam:NAMH_1653 chain length determinant protein. (297 aa) |
| | Sdel_1769 | PFAM: polysaccharide biosynthesis protein CapD; Male sterility domain; dTDP-4-dehydrorhamnose reductase; short-chain dehydrogenase/reductase SDR; NAD-dependent epimerase/dehydratase; KEGG: abu:Abu_0696 sugar epimerase/dehydratase. (577 aa) |
| | Sdel_1770 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (190 aa) |
| | Sdel_1771 | PFAM: Glycosyl transferase, family 4, conserved region; KEGG: abu:Abu_0694 glycosyltransferase. (321 aa) |
| | Sdel_1772 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; dTDP-4-dehydrorhamnose reductase; KEGG: bba:Bd1697 UDP-N-acetyl-D-quinovosamine 4- epimerase. (285 aa) |
| | Sdel_1773 | PFAM: glycosyl transferase family 2; KEGG: abc:ACICU_00086 glycosyltransferase. (272 aa) |
| | Sdel_1780 | Acetyltransferase; KEGG: rfr:Rfer_0688 acetyltransferase. (203 aa) |
| | Sdel_1785 | TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; KEGG: abu:Abu_1816 dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (346 aa) |
| | fcl | NAD-dependent epimerase/dehydratase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (310 aa) |
| | gmd | GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (372 aa) |
| | Sdel_1792 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; dTDP-4-dehydrorhamnose reductase; KEGG: tdn:Suden_0894 NAD-dependent epimerase/dehydratase. (353 aa) |
| | Sdel_1795 | Nucleotide sugar dehydrogenase; KEGG: abu:Abu_0659 UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP- glucose/GDP-mannose dehydrogenase dimerisation; UDP- glucose/GDP-mannose dehydrogenase. (389 aa) |
| | Sdel_1797 | TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; KEGG: abu:Abu_1816 dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (338 aa) |
| | Sdel_1804 | KEGG: abu:Abu_1801 hypothetical protein. (347 aa) |
| | Sdel_1805 | PFAM: glycosyl transferase family 9; KEGG: abu:Abu_1800 lipopolysaccharide heptosyltransferase II. (308 aa) |
| | Sdel_1806 | PFAM: glycosyl transferase group 1; KEGG: tdn:Suden_0588 glycosyl transferase, group 1. (359 aa) |
| | Sdel_1808 | TIGRFAM: lipopolysaccharide heptosyltransferase I; PFAM: glycosyl transferase family 9; KEGG: tdn:Suden_0589 lipopolysaccharide heptosyltransferase I. (327 aa) |
| | Sdel_1809 | Hypothetical protein; KEGG: tau:Tola_0027 glycosyl transferase group 1. (154 aa) |
| | Sdel_1810 | PFAM: lipid A biosynthesis acyltransferase; KEGG: ccv:CCV52592_1229 lipid A biosynthesis lauroyl acyltransferase. (306 aa) |
| | Sdel_1811 | PFAM: O-antigen polymerase; KEGG: tdn:Suden_1699 O-antigen polymerase. (417 aa) |
| | gmhA | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (188 aa) |
| | hldE | rfaE bifunctional protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (472 aa) |
| | Sdel_1815 | TIGRFAM: D,D-heptose 1,7-bisphosphate phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: Polynucleotide kinase 3 phosphatase central region; KEGG: nis:NIS_1450 D-glycero-D-manno-heptose 1,7- bisphosphate phosphatase. (169 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (312 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate- independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (496 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide-transferas e; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (354 aa) |
| | Sdel_1840 | UDP-N-acetylmuramoylalanine/D-glutamate ligase; KEGG: cff:CFF8240_1358 UDP-N-acetylmuramoyl-L- alanyl-D-glutamate synthetase; TIGRFAM: UDP-N-acetylmuramoylalanine/D-glutamate ligase; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; Belongs to the MurCDEF family. (397 aa) |
| | Sdel_1847 | PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; RimK domain protein ATP-grasp; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: abu:Abu_0605 acetyl CoA carboxylase, biotin carboxylase subunit. (481 aa) |
| | Sdel_1848 | KEGG: abu:Abu_1549 CiaB protein. (621 aa) |
| | Sdel_1875 | PFAM: thioesterase superfamily protein; KEGG: cla:Cla_1269 conserved hypothetical protein, putative acyl-coA thioester hydrolase. (139 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (222 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (192 aa) |
| | Sdel_1879 | KEGG: wsu:WS1659 hypothetical protein. (180 aa) |
| | Sdel_1882 | PFAM: metallophosphoesterase; KEGG: wsu:WS1724 hypothetical protein. (255 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (386 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl- phosphate synthase small chain; KEGG: sun:SUN_0176 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (376 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (415 aa) |
| | Sdel_1933 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (656 aa) |
| | murE | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (437 aa) |
| | Sdel_1977 | KEGG: ccv:CCV52592_2067 TPR repeat-containing protein. (347 aa) |
| | Sdel_2003 | PFAM: Lytic transglycosylase catalytic; KEGG: tdn:Suden_1800 lytic transglycosylase, catalytic. (207 aa) |
| | Sdel_2014 | KEGG: cha:CHAB381_0073 hypothetical protein. (178 aa) |
| | uppP | Undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (255 aa) |
| | Sdel_2037 | PFAM: sulfatase; protein of unknown function DUF1705; KEGG: wsu:WS0643 hypothetical protein. (518 aa) |
| | Sdel_2098 | PFAM: glycosyl transferase family 2; KEGG: ppd:Ppro_0921 glycosyl transferase family protein. (234 aa) |
| | Sdel_2099 | PFAM: lipid A biosynthesis acyltransferase; KEGG: saz:Sama_3384 glycosyl transferase, group 2 family protein. (287 aa) |
| | Sdel_2105 | KEGG: fph:Fphi_1084 aconitate hydratase. (393 aa) |
| | Sdel_2144 | PFAM: MltA domain protein; 3D domain protein; KEGG: tdn:Suden_1285 MltA. (356 aa) |
| | Sdel_2155 | Flagellar protein export ATPase FliI; KEGG: ccv:CCV52592_1495 flagellum-specific ATP synthase; TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (434 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (192 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (212 aa) |
| | Sdel_2198 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (443 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (186 aa) |
| | Sdel_2208 | TIGRFAM: UDP-N-acetylglucosamine 4,6-dehydratase; PFAM: polysaccharide biosynthesis protein CapD; 3- beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; dTDP-4-dehydrorhamnose reductase; short- chain dehydrogenase/reductase SDR; NAD-dependent epimerase/dehydratase; KEGG: ccv:CCV52592_0560 polysaccharide biosynthesis protein. (329 aa) |
| | Sdel_2210 | TIGRFAM: pseudaminic acid CMP-transferase; PFAM: acylneuraminate cytidylyltransferase; KEGG: abu:Abu_2245 acylneuraminate cytidylyltransferase. (232 aa) |
| | Sdel_2217 | PFAM: glycosyl transferase group 1; KEGG: tdn:Suden_0191 glycosyl transferase, group 1. (385 aa) |
| | Sdel_2222 | PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; KEGG: acp:A2cp1_4443 dTDP-glucose 4,6-dehydratase. (345 aa) |
| | Sdel_2223 | Hypothetical protein; KEGG: cco:CCC13826_0529 DedA family protein. (429 aa) |
| | Sdel_2227 | KEGG: wsu:WS2197 hypothetical protein. (672 aa) |
| | Sdel_2228 | PFAM: protein of unknown function DUF115; KEGG: hps:HPSH_00575 hypothetical protein. (627 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (423 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (257 aa) |
| | Sdel_2246 | PFAM: metallophosphoesterase; KEGG: ccv:CCV52592_1132 cytoplasmic membrane protein. (373 aa) |
