STRINGSTRING
SEB00748.1 SEB00748.1 SEA91326.1 SEA91326.1 SEA91065.1 SEA91065.1 SEA86378.1 SEA86378.1 pyrG pyrG SEA75118.1 SEA75118.1 SEA69173.1 SEA69173.1 SEA63333.1 SEA63333.1 dut dut pyrH pyrH pyrD pyrD SEA54940.1 SEA54940.1 SEA48120.1 SEA48120.1 pyrC pyrC ppnP ppnP cmk cmk pyrF pyrF dcd dcd pyrE pyrE tgt tgt tmk tmk SEA28636.1 SEA28636.1 rlmL rlmL SEA23491.1 SEA23491.1 ndk ndk tadA tadA nrdR nrdR SDZ97704.1 SDZ97704.1 SDZ95333.1 SDZ95333.1 SDZ95258.1 SDZ95258.1 SDZ92430.1 SDZ92430.1 pyrB pyrB SDZ87272.1 SDZ87272.1 SDZ86229.1 SDZ86229.1 SDZ86167.1 SDZ86167.1 SDZ83969.1 SDZ83969.1 SDZ77865.1 SDZ77865.1 surE surE SEA91732.1 SEA91732.1 SEA91907.1 SEA91907.1 SEA94011.1 SEA94011.1 thyA thyA groS groS SEA96157.1 SEA96157.1 SEA96244.1 SEA96244.1 SEA97333.1 SEA97333.1 SEB01845.1 SEB01845.1 carA carA carB carB SEB02789.1 SEB02789.1 SEB02841.1 SEB02841.1 SEB03814.1 SEB03814.1 SEB05432.1 SEB05432.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEB00748.1MFS transporter, UMF1 family. (417 aa)
SEA91326.1NACHT domain-containing protein. (539 aa)
SEA91065.1Reactive intermediate/imine deaminase. (127 aa)
SEA86378.1Hypothetical protein; Belongs to the LOG family. (241 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (552 aa)
SEA75118.15'-nucleotidase; Belongs to the 5'-nucleotidase family. (617 aa)
SEA69173.1MFS transporter, PPP family, 3-phenylpropionic acid transporter. (392 aa)
SEA63333.1Dihydroorotase. (445 aa)
dutdUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (244 aa)
pyrDDihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (338 aa)
SEA54940.1Endonuclease YncB, thermonuclease family. (192 aa)
SEA48120.1Hypothetical protein. (236 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (342 aa)
ppnPHypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (103 aa)
cmkCytidylate kinase. (217 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (229 aa)
dcddCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (370 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa)
SEA28636.1Short-chain dehydrogenase. (279 aa)
rlmL23S rRNA (guanine2445-N2)-methyltransferase / 23S rRNA (guanine2069-N7)-methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (711 aa)
SEA23491.123S rRNA (cytosine1962-C5)-methyltransferase; Belongs to the methyltransferase superfamily. (286 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
tadAtRNA(adenine34) deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (161 aa)
nrdRTranscriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (169 aa)
SDZ97704.1Hypothetical protein. (241 aa)
SDZ95333.1Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (188 aa)
SDZ95258.1Pyrimidine operon attenuation protein / uracil phosphoribosyltransferase. (168 aa)
SDZ92430.1Dihydroorotase. (424 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (331 aa)
SDZ87272.1HNH endonuclease. (225 aa)
SDZ86229.1Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (1274 aa)
SDZ86167.1Ribonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (426 aa)
SDZ83969.1Putative hydrolase of the HAD superfamily. (225 aa)
SDZ77865.15-methylcytosine-specific restriction endonuclease McrA. (200 aa)
surE5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (243 aa)
SEA91732.1Hypothetical protein. (341 aa)
SEA91907.1TIR domain-containing protein. (912 aa)
SEA94011.1BON domain-containing protein. (147 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
groSChaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
SEA96157.1LVIVD repeat-containing protein. (782 aa)
SEA96244.12',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase; Belongs to the 5'-nucleotidase family. (656 aa)
SEA97333.1LysM domain-containing protein. (371 aa)
SEB01845.1NTP pyrophosphatase, house-cleaning of non-canonical NTPs. (118 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (379 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1076 aa)
SEB02789.1HNH endonuclease. (108 aa)
SEB02841.1HNH endonuclease. (141 aa)
SEB03814.1Na+/melibiose symporter. (453 aa)
SEB05432.1HNH endonuclease. (116 aa)
Your Current Organism:
Thiothrix caldifontis
NCBI taxonomy Id: 525918
Other names: DSM 21228, T. caldifontis, Thiothrix caldifontis Chernousova et al. 2009, VKM B-2520, strain G1
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