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tmk tmk ACZ07204.1 ACZ07204.1 ACZ07233.1 ACZ07233.1 ACZ07234.1 ACZ07234.1 ACZ07235.1 ACZ07235.1 ACZ07265.1 ACZ07265.1 ACZ07418.1 ACZ07418.1 ACZ07464.1 ACZ07464.1 ACZ07479.1 ACZ07479.1 upp upp ACZ07626.1 ACZ07626.1 ACZ07665.1 ACZ07665.1 ACZ07811.1 ACZ07811.1 ACZ07812.1 ACZ07812.1 ACZ07813.1 ACZ07813.1 folD folD apt apt ade ade guaB guaB guaA guaA thyA thyA ACZ08469.1 ACZ08469.1 ACZ08524.1 ACZ08524.1 ACZ08525.1 ACZ08525.1 ACZ08526.1 ACZ08526.1 ACZ08527.1 ACZ08527.1 ACZ08528.1 ACZ08528.1 ACZ08542.1 ACZ08542.1 ACZ08641.1 ACZ08641.1 ACZ08647.1 ACZ08647.1 ACZ08650.1 ACZ08650.1 ACZ08651.1 ACZ08651.1 ACZ08652.1 ACZ08652.1 ACZ08740.1 ACZ08740.1 ACZ08901.1 ACZ08901.1 fhs fhs ACZ08960.1 ACZ08960.1 purE purE purC purC purF purF purM purM purN purN purH purH purD purD ACZ09002.1 ACZ09002.1 purA purA ACZ09004.1 ACZ09004.1 ACZ09116.1 ACZ09116.1 glyA glyA ACZ09335.1 ACZ09335.1 ACZ09467.1 ACZ09467.1 pyrE pyrE ACZ09508.1 ACZ09508.1 pyrF pyrF pyrD pyrD ACZ09511.1 ACZ09511.1 pyrI pyrI pyrB pyrB carB carB carA carA dut dut xpt xpt gmk gmk ACZ09813.1 ACZ09813.1 tdk tdk udk udk ACZ10460.1 ACZ10460.1 ACZ10568.1 ACZ10568.1 ACZ10595.1 ACZ10595.1 ACZ10909.1 ACZ10909.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (227 aa)
ACZ07204.1PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: sat:SYN_02264 UDP-sugar diphosphatase / 5'- nucleotidase; Belongs to the 5'-nucleotidase family. (489 aa)
ACZ07233.1TIGRFAM: NAD pyrophosphatase/5'-nucleotidase NadN; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: hiq:CGSHiGG_03645 NAD nucleotidase; Belongs to the 5'-nucleotidase family. (591 aa)
ACZ07234.1PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: apj:APJL_1779 2',3'-cyclic-nucleotide 2'- phosphodiesterase; Belongs to the 5'-nucleotidase family. (547 aa)
ACZ07235.1PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: hpy:HP0104 2',3'-cyclic-nucleotide 2'- phosphodiesterase (CpdB); Belongs to the 5'-nucleotidase family. (579 aa)
ACZ07265.1PFAM: cyclic-AMP phosphodiesterase class-II; KEGG: yps:YPTB2912 putative 3',5'-cyclic-nucleotide phosphodiesterase. (329 aa)
ACZ07418.1PFAM: purine or other phosphorylase family 1; KEGG: sse:Ssed_2504 uridine phosphorylase. (248 aa)
ACZ07464.1Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (427 aa)
ACZ07479.1TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: pau:PA14_61480 uracil permease. (403 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (207 aa)
ACZ07626.1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (250 aa)
ACZ07665.1TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: afw:Anae109_2748 putative trifunctional 2- polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein. (761 aa)
ACZ07811.1TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: ppw:PputW619_2057 xanthine permease. (436 aa)
ACZ07812.1PFAM: CMP/dCMP deaminase zinc-binding; KEGG: avi:Avi_5084 CMP/dCMP deaminase zinc-binding. (160 aa)
ACZ07813.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: pca:Pcar_0417 D-3-phosphoglycerate dehydrogenase. (326 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
adeKEGG: dvl:Dvul_2495 adenine deaminase; TIGRFAM: adenine deaminase; PFAM: amidohydrolase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (568 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (512 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (289 aa)
ACZ08469.1Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (155 aa)
ACZ08524.1Hypothetical protein. (92 aa)
ACZ08525.1TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: dps:DP1412 xanthine permease. (450 aa)
ACZ08526.1TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: dps:DP1412 xanthine permease. (465 aa)
ACZ08527.1S-adenosylhomocysteine deaminase; PFAM: amidohydrolase; Amidohydrolase 3; KEGG: bur:Bcep18194_A5267 hydroxydechloroatrazine ethylaminohydrolase. (462 aa)
ACZ08528.1TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: reh:H16_A1007 nucleobase:cation symporter 2 (NCS2) family transporter. (460 aa)
ACZ08542.1TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3; KEGG: shl:Shal_0638 phenylhydantoinase. (464 aa)
ACZ08641.1Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
ACZ08647.1KEGG: mxa:MXAN_5710 pyrimidine-nucleoside phosphorylase; TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: Pyrimidine nucleoside phosphorylase domain; glycosyl transferase family 3; Glycosyl transferase, family 3-like. (435 aa)
ACZ08650.1PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: apl:APL_1743 Ser/Thr protein phosphatase family protein; Belongs to the 5'-nucleotidase family. (549 aa)
ACZ08651.1TIGRFAM: purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1; KEGG: asa:ASA_3652 purine nucleoside phosphorylase. (232 aa)
ACZ08652.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (133 aa)
ACZ08740.1TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; KEGG: dat:HRM2_17030 FolC; Belongs to the folylpolyglutamate synthase family. (407 aa)
ACZ08901.1KEGG: spe:Spro_3998 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (184 aa)
fhsPFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: pmr:PMI0670 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (553 aa)
ACZ08960.1KEGG: dno:DNO_1110 phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. (1244 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa)
purCKEGG: dno:DNO_1112 phosphoribosylaminoimidazole- succinocarboxamidesynthase; TIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase. (235 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (475 aa)
purMKEGG: dno:DNO_1113 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (331 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (189 aa)
purHKEGG: har:HEAR0255 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. (500 aa)
purDPhosphoribosylamine/glycine ligase; KEGG: dno:DNO_0940 phosphoribosylglycinamide synthetase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. (416 aa)
ACZ09002.1KEGG: vfm:VFMJ11_2290 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (425 aa)
ACZ09004.1TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ADL; adenylosuccinate lyase; K01756 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (479 aa)
ACZ09116.1PFAM: Xanthine/uracil/vitamin C permease; KEGG: seh:SeHA_C0631 putative purine permease YbbY. (431 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
ACZ09335.1PFAM: CMP/dCMP deaminase zinc-binding; KEGG: similar to dCMP deaminase; K01493 dCMP deaminase. (164 aa)
ACZ09467.1FolC bifunctional protein; KEGG: rco:RC0779 folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein. (413 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (207 aa)
ACZ09508.1TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: afr:AFE_1463 dihydroorotase. (418 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (322 aa)
ACZ09511.1PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: gsu:GSU1756 dihydroorotate dehydrogenase, electron transfer subunit, putative. (271 aa)
pyrIAspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (149 aa)
pyrBKEGG: cvi:CV_0369 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
carBTIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; RimK domain protein ATP-grasp; phosphoribosylglycinamide synthetase; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; protein of unknown function DUF201; KEGG: dat:HRM2_47760 CarB2; Belongs to the CarB family. (1069 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: pca:Pcar_1613 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (351 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (146 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (181 aa)
ACZ09813.1Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (195 aa)
tdkPFAM: thymidine kinase; KEGG: mxa:MXAN_5072 thymidine kinase. (357 aa)
udkTIGRFAM: uridine kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mxa:MXAN_4159 uridine kinase. (213 aa)
ACZ10460.1Ribosylpyrimidine nucleosidase; PFAM: Inosine/uridine-preferring nucleoside hydrolase; KEGG: eum:ECUMN_2498 ribonucleoside hydrolase 2. (308 aa)
ACZ10568.1Ribosylpyrimidine nucleosidase; PFAM: Inosine/uridine-preferring nucleoside hydrolase; KEGG: elf:LF82_1884 pyrimidine-specific ribonucleoside hydrolase RihB. (310 aa)
ACZ10595.1PFAM: Ham1 family protein; KEGG: bja:bll0673 putative deoxyribonucleotide triphosphate pyrophosphatase. (204 aa)
ACZ10909.1KEGG: hch:HCH_05422 dihydrofolate reductase. (172 aa)
Your Current Organism:
Sebaldella termitidis
NCBI taxonomy Id: 526218
Other names: S. termitidis ATCC 33386, Sebaldella termitidis ATCC 33386, Sebaldella termitidis NCTC 11300, Sebaldella termitidis str. ATCC 33386, Sebaldella termitidis strain ATCC 33386
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