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ACZ06914.1 ACZ06914.1 ACZ06915.1 ACZ06915.1 ACZ06916.1 ACZ06916.1 ACZ06917.1 ACZ06917.1 ACZ06920.1 ACZ06920.1 ilvD ilvD ACZ06988.1 ACZ06988.1 ACZ06989.1 ACZ06989.1 ACZ06990.1 ACZ06990.1 ACZ06991.1 ACZ06991.1 leuA leuA ACZ06993.1 ACZ06993.1 ACZ06995.1 ACZ06995.1 ACZ06998.1 ACZ06998.1 leuB leuB ilvC ilvC ACZ07038.1 ACZ07038.1 ACZ07142.1 ACZ07142.1 ACZ07156.1 ACZ07156.1 ACZ07183.1 ACZ07183.1 ACZ07373.1 ACZ07373.1 ACZ07374.1 ACZ07374.1 ACZ07438.1 ACZ07438.1 ACZ07439.1 ACZ07439.1 ACZ07941.1 ACZ07941.1 ACZ07942.1 ACZ07942.1 ACZ07968.1 ACZ07968.1 ACZ08047.1 ACZ08047.1 ACZ08377.1 ACZ08377.1 accD accD accA accA ACZ08607.1 ACZ08607.1 ACZ08793.1 ACZ08793.1 ACZ08794.1 ACZ08794.1 ACZ09007.1 ACZ09007.1 ACZ09008.1 ACZ09008.1 ACZ09009.1 ACZ09009.1 ACZ09193.1 ACZ09193.1 ACZ09194.1 ACZ09194.1 ACZ09195.1 ACZ09195.1 fabZ fabZ ACZ09239.1 ACZ09239.1 ACZ09314.1 ACZ09314.1 ACZ09317.1 ACZ09317.1 fabH fabH ldh ldh ACZ09563.1 ACZ09563.1 ACZ09564.1 ACZ09564.1 fabV fabV ACZ09954.1 ACZ09954.1 ACZ10098.1 ACZ10098.1 ACZ10099.1 ACZ10099.1 ACZ10100.1 ACZ10100.1 ACZ10279.1 ACZ10279.1 ACZ10449.1 ACZ10449.1 ACZ10470.1 ACZ10470.1 ACZ10472.1 ACZ10472.1 ACZ10473.1 ACZ10473.1 ACZ10537.1 ACZ10537.1 ACZ10579.1 ACZ10579.1 ACZ10602.1 ACZ10602.1 ACZ10603.1 ACZ10603.1 ACZ10604.1 ACZ10604.1 ACZ10605.1 ACZ10605.1 ACZ10606.1 ACZ10606.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ACZ06914.1TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide- disulphide oxidoreductase; glucose-inhibited division protein A; HI0933 family protein; biotin/lipoyl attachment domain-containing protein; KEGG: pla:Plav_3138 dihydrolipoamide dehydrogenase. (563 aa)
ACZ06915.1PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain- containing protein; E3 binding domain protein; KEGG: dat:HRM2_47640 PdhC. (442 aa)
ACZ06916.1PFAM: Transketolase central region; Transketolase domain protein; KEGG: dat:HRM2_47610 PdhB. (327 aa)
ACZ06917.1PFAM: dehydrogenase E1 component; KEGG: oan:Oant_4117 pyruvate dehydrogenase (acetyl- transferring). (320 aa)
ACZ06920.1PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ecl:EcolC_1649 short-chain dehydrogenase/reductase SDR. (252 aa)
ilvDKEGG: sat:SYN_01708 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (552 aa)
ACZ06988.1TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: ade:Adeh_3448 L-threonine ammonia-lyase. (401 aa)
ACZ06989.1TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: sfu:Sfum_3025 acetolactate synthase, small subunit. (161 aa)
ACZ06990.1TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; KEGG: geo:Geob_1509 acetolactate synthase, large subunit, biosynthetic type. (568 aa)
ACZ06991.1TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dds:Ddes_1904 acetolactate synthase, small subunit. (162 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (505 aa)
ACZ06993.1TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: geo:Geob_2938 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (529 aa)
ACZ06995.1TIGRFAM: homoaconitate hydratase family protein; 3- isopropylmalate dehydratase; PFAM: aconitate hydratase domain protein; KEGG: 3-isopropylmalate dehydratase; K01703 3- isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Belongs to the aconitase/IPM isomerase family. (435 aa)
ACZ06998.1TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: 3-isopropylmalate dehydratase small subunit; K01704 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Belongs to the LeuD family. (181 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (352 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (359 aa)
ACZ07038.1TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase; KEGG: fph:Fphi_0269 biotin-(acetyl-CoA-carboxylase) ligase. (231 aa)
ACZ07142.1PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: pca:Pcar_2295 putative oxidoreductase. (413 aa)
ACZ07156.1PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: ank:AnaeK_3118 glutamate dehydrogenase (NADP(+)); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa)
ACZ07183.13-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (410 aa)
ACZ07373.1TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: gur:Gura_3720 acetolactate synthase, large subunit, biosynthetic type. (566 aa)
ACZ07374.1TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: pha:PSHAb0463 acetolactate synthase 3 regulatory subunit. (162 aa)
ACZ07438.1TIGRFAM: ammonium transporter; PFAM: Rh family protein/ammonium transporter; KEGG: ppd:Ppro_0486 ammonium transporter. (422 aa)
ACZ07439.1PFAM: nitrogen regulatory protein P-II; KEGG: wsu:WS0409 nitrogen regulatory protein P-II. (111 aa)
ACZ07941.1KEGG: ecc:c4538 putative pyruvate formate-lyase 3 activating enzyme; TIGRFAM: glycyl-radical enzyme activating protein family; PFAM: Radical SAM domain protein. (298 aa)
ACZ07942.1Pyruvate formate-lyase; KEGG: ses:SARI_02080 hypothetical protein; TIGRFAM: pyruvate formate-lyase; PFAM: pyruvate formate-lyase PFL; formate C- acetyltransferase glycine radical. (802 aa)
ACZ07968.1PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: dps:DP2376 biotin synthase. (364 aa)
ACZ08047.1acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa)
ACZ08377.1PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: sfr:Sfri_1898 iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (863 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (314 aa)
ACZ08607.1acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
ACZ08793.1KEGG: tau:Tola_1902 pyruvate formate-lyase; TIGRFAM: pyruvate formate-lyase; PFAM: pyruvate formate-lyase PFL; formate C- acetyltransferase glycine radical. (765 aa)
ACZ08794.1KEGG: tau:Tola_1901 glycyl-radical enzyme activating protein family; TIGRFAM: glycyl-radical enzyme activating protein family; PFAM: Radical SAM domain protein. (273 aa)
ACZ09007.1TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain protein; KEGG: dal:Dalk_3952 aconitate hydratase. (644 aa)
ACZ09008.1PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: aha:AHA_1152 isocitrate dehydrogenase. (333 aa)
ACZ09009.1PFAM: Citrate synthase; KEGG: noc:Noc_2628 methylcitrate synthase. (441 aa)
ACZ09193.1TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mca:MCA2040 glutamate synthase subunit beta. (482 aa)
ACZ09194.1PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; KEGG: glo:Glov_3016 glutamate synthase (ferredoxin). (1483 aa)
ACZ09195.1PFAM: glutamine synthetase catalytic region; KEGG: sat:SYN_01613 glutamine synthetase. (702 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (141 aa)
ACZ09239.1KEGG: bba:Bd1150 pyruvate phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate- binding; PEP-utilising protein mobile region; PEP- utilizing protein; Belongs to the PEP-utilizing enzyme family. (880 aa)
ACZ09314.13-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (411 aa)
ACZ09317.1TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: pca:Pcar_1437 malonyl CoA-acyl carrier protein transacylase. (301 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (318 aa)
ACZ09563.1KEGG: tau:Tola_0881 formate acetyltransferase; TIGRFAM: formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C- acetyltransferase glycine radical. (742 aa)
ACZ09564.1Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (241 aa)
fabVTrans-2-enoyl-CoA reductase (NAD(+)); Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (397 aa)
ACZ09954.1PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier- protein (ACP)] synthase III; KEGG: lpp:lpp1601 3-oxoacyl-(acyl carrier protein) synthase III. (325 aa)
ACZ10098.1Transcriptional regulator, DeoR family; PFAM: regulatory protein DeoR; SMART: regulatory protein DeoR; KEGG: bpy:Bphyt_4951 transcriptional regulator, DeoR family. (251 aa)
ACZ10099.1KEGG: dat:HRM2_49340 PflC2; TIGRFAM: glycyl-radical enzyme activating protein family; PFAM: Radical SAM domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein. (303 aa)
ACZ10100.1KEGG: tau:Tola_2307 pyruvate formate-lyase; TIGRFAM: pyruvate formate-lyase; PFAM: pyruvate formate-lyase PFL; formate C- acetyltransferase glycine radical. (805 aa)
ACZ10279.1PFAM: short-chain dehydrogenase/reductase SDR; KEGG: oca:OCAR_5704 oxidoreductase, short chain dehydrogenase/reductase family. (264 aa)
ACZ10449.1TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: cco:CCC13826_1933 pyruvate:ferredoxin (flavodoxin) oxidoreductase. (1178 aa)
ACZ10470.1PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; NAD-dependent epimerase/dehydratase; KEGG: shl:Shal_2747 short-chain dehydrogenase/reductase SDR. (236 aa)
ACZ10472.1TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: ppd:Ppro_0548 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit. (286 aa)
ACZ10473.1PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: dps:DP2103 2-oxoacid ferredoxin oxidoreductase, alpha subunit. (551 aa)
ACZ10537.1KEGG: vpa:VPA1567 putative pyruvate formate lyase; TIGRFAM: pyruvate formate-lyase; PFAM: pyruvate formate-lyase PFL; formate C- acetyltransferase glycine radical. (807 aa)
ACZ10579.1PFAM: BioY protein; KEGG: mes:Meso_0776 BioY protein. (190 aa)
ACZ10602.1KEGG: asu:Asuc_0554 lipoyltransferase and lipoate- protein ligase; TIGRFAM: lipoyltransferase and lipoate-protein ligase; PFAM: biotin/lipoate A/B protein ligase. (329 aa)
ACZ10603.1TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide- disulphide oxidoreductase; glucose-inhibited division protein A; HI0933 family protein; biotin/lipoyl attachment domain-containing protein; KEGG: pla:Plav_3138 dihydrolipoamide dehydrogenase. (562 aa)
ACZ10604.1PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain- containing protein; E3 binding domain protein; KEGG: dat:HRM2_47640 PdhC. (442 aa)
ACZ10605.1PFAM: Transketolase central region; Transketolase domain protein; KEGG: dat:HRM2_47610 PdhB. (327 aa)
ACZ10606.1PFAM: dehydrogenase E1 component; KEGG: oan:Oant_4117 pyruvate dehydrogenase (acetyl- transferring). (320 aa)
Your Current Organism:
Sebaldella termitidis
NCBI taxonomy Id: 526218
Other names: S. termitidis ATCC 33386, Sebaldella termitidis ATCC 33386, Sebaldella termitidis NCTC 11300, Sebaldella termitidis str. ATCC 33386, Sebaldella termitidis strain ATCC 33386
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