STRINGSTRING
ACZ07054.1 ACZ07054.1 ACZ07055.1 ACZ07055.1 ACZ07141.1 ACZ07141.1 ACZ07258.1 ACZ07258.1 murE murE ACZ07612.1 ACZ07612.1 ACZ07659.1 ACZ07659.1 asnA asnA ACZ08523.1 ACZ08523.1 ACZ08567.1 ACZ08567.1 ACZ08711.1 ACZ08711.1 argC argC ACZ08761.1 ACZ08761.1 argJ argJ argB argB argD argD ACZ08765.1 ACZ08765.1 ACZ08824.1 ACZ08824.1 ACZ09023.1 ACZ09023.1 ACZ09024.1 ACZ09024.1 metAA metAA ACZ09026.1 ACZ09026.1 ACZ09027.1 ACZ09027.1 hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI ACZ09036.1 ACZ09036.1 pdxS pdxS pdxT pdxT ACZ09039.1 ACZ09039.1 ACZ09040.1 ACZ09040.1 ACZ09041.1 ACZ09041.1 ACZ09092.1 ACZ09092.1 ACZ09122.1 ACZ09122.1 argH argH argG argG ACZ09142.1 ACZ09142.1 aroK aroK aroE aroE ACZ09228.1 ACZ09228.1 aroC aroC aroA aroA aroB aroB ACZ09279.1 ACZ09279.1 ACZ09280.1 ACZ09280.1 ACZ09386.1 ACZ09386.1 thrB thrB ACZ09806.1 ACZ09806.1 ACZ09812.1 ACZ09812.1 ACZ09819.1 ACZ09819.1 dapB dapB asd asd dapA dapA ACZ09831.1 ACZ09831.1 dapF dapF ACZ09833.1 ACZ09833.1 lysA lysA ACZ09856.1 ACZ09856.1 ACZ09857.1 ACZ09857.1 ACZ09863.1 ACZ09863.1 ACZ09905.1 ACZ09905.1 ACZ09923.1 ACZ09923.1 ACZ10121.1 ACZ10121.1 ACZ10140.1 ACZ10140.1 ACZ10141.1 ACZ10141.1 trpD trpD ACZ10143.1 ACZ10143.1 trpF trpF trpB trpB trpA trpA ACZ10180.1 ACZ10180.1 pepA pepA ACZ10233.1 ACZ10233.1 ACZ10282.1 ACZ10282.1 ACZ10283.1 ACZ10283.1 aguA aguA ACZ10285.1 ACZ10285.1 ACZ10286.1 ACZ10286.1 ACZ10323.1 ACZ10323.1 ACZ10612.1 ACZ10612.1 ACZ10835.1 ACZ10835.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ACZ07054.1TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; KEGG: hac:Hac_0304 hypothetical protein. (175 aa)
ACZ07055.1TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: gme:Gmet_2988 cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa)
ACZ07141.1Hypothetical protein; KEGG: ATP-dependent RNA helicase; K01509 adenosinetriphosphatase. (212 aa)
ACZ07258.1KEGG: ASNS; asparagine synthetase; K01953 asparagine synthase (glutamine-hydrolysing); TIGRFAM: asparagine synthase (glutamine- hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. (528 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (481 aa)
ACZ07612.1Branched-chain-amino-acid transaminase; PFAM: aminotransferase class IV; KEGG: dar:Daro_3294 branched-chain amino acid aminotransferase. (312 aa)
ACZ07659.1Carbamate kinase; KEGG: ecw:EcE24377A_3199 carbamate kinase; TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (312 aa)
asnAKEGG: aspartate--ammonia ligase; K01914 aspartate--ammonia ligase; TIGRFAM: aspartate/ammonia ligase; PFAM: aspartate--ammonia ligase. (336 aa)
ACZ08523.1Carbamate kinase; KEGG: ecw:EcE24377A_3199 carbamate kinase; TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (313 aa)
ACZ08567.1TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; KEGG: nam:NAMH_1464 histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (289 aa)
ACZ08711.1PFAM: PHP domain protein; KEGG: nam:NAMH_1464 histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (257 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (345 aa)
ACZ08761.1PFAM: GCN5-related N-acetyltransferase; KEGG: mms:mma_2445 phosphinothricin N- acetyltransferase. (165 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (291 aa)
argDKEGG: sat:SYN_02155 acetylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (387 aa)
ACZ08765.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (331 aa)
ACZ08824.1TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; KEGG: tdn:Suden_1866 histidinol phosphate phosphatase, HisJ; Belongs to the PHP hydrolase family. HisK subfamily. (268 aa)
ACZ09023.1O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: sat:SYN_01255 O-acetyl-L-homoserine sulfhydrolase / O-acetyl-L-serine sulfhydrolase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase. (423 aa)
ACZ09024.1KEGG: cju:C8J_1146 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (292 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (289 aa)
ACZ09026.1Hypothetical protein. (151 aa)
ACZ09027.1PFAM: tRNA synthetase class II (G H P and S); KEGG: gbm:Gbem_0553 histidyl-tRNA synthetase. (375 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (205 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mmw:Mmwyl1_1133 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (355 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: azc:AZC_4502 imidazoleglycerol-phosphate dehydratase. (196 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (204 aa)
hisAKEGG: cco:CCC13826_0444 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. (237 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa)
hisITIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: nis:NIS_1544 histidine biosynthesis bifunctional protein HisI; In the N-terminal section; belongs to the PRA-CH family. (217 aa)
ACZ09036.1TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; KEGG: abu:Abu_1904 histidinol-phosphate phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (279 aa)
pdxSPyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (291 aa)
pdxTSNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (188 aa)
ACZ09039.1Conserved hypothetical protein; KEGG: sml:Smlt3468 putative transmembrane protein. (186 aa)
ACZ09040.1PFAM: Methylated-DNA-[protein]-cysteine S- methyltransferase DNA binding; KEGG: dde:Dde_3099 methylated-DNA--protein-cysteine methyltransferase. (113 aa)
ACZ09041.1KEGG: vfm:VFMJ11_0497 acetyltransferase, GNAT family. (84 aa)
ACZ09092.1PFAM: aminotransferase class I and II; KEGG: ftn:FTN_0410 aspartate aminotransferase. (396 aa)
ACZ09122.1KEGG: nis:NIS_1040 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (497 aa)
argHTIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: pca:Pcar_2418 argininosuccinate lyase. (461 aa)
argGKEGG: argininosuccinate synthase; K01940 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa)
ACZ09142.1TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: sfu:Sfum_1692 phosphomethylpyrimidine kinase. (269 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (165 aa)
aroEShikimate dehydrogenase substrate binding domain protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa)
ACZ09228.1Chorismate mutase; KEGG: vsp:VS_0556 P-protein [includes: chorismate mutase,Prephenatedehydratase]; TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; Chorismate mutase. (378 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (424 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (354 aa)
ACZ09279.1PFAM: Prephenate dehydrogenase; KEGG: maq:Maqu_1025 3-phosphoshikimate 1- carboxyvinyltransferase. (282 aa)
ACZ09280.1Phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: gme:Gmet_0346 3-deoxy-7-phosphoheptulonate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (340 aa)
ACZ09386.1KEGG: Protein kinase domain containing protein. (317 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa)
ACZ09806.1KEGG: vvu:VV1_0333 aminoacyl-histidine dipeptidase; TIGRFAM: aminoacyl-histidine dipeptidase; PFAM: peptidase dimerisation domain protein; peptidase M20. (487 aa)
ACZ09812.1PFAM: aminotransferase class I and II; KEGG: ypg:YpAngola_A2760 aminotransferase, classes I and II. (386 aa)
ACZ09819.1Tetrahydrodipicolinate succinyltransferase domain protein; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (231 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (241 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (332 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
ACZ09831.1KEGG: bcs:BCAN_A0953 hypothetical protein. (145 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (285 aa)
ACZ09833.1TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: hhe:HH0618 aspartate kinase; Belongs to the aspartokinase family. (400 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (435 aa)
ACZ09856.1KEGG: sfu:Sfum_2173 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (406 aa)
ACZ09857.1PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: glo:Glov_1214 homoserine dehydrogenase. (398 aa)
ACZ09863.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: bxe:Bxe_B2346 putative dehydrogenase. (313 aa)
ACZ09905.1TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: gur:Gura_3907 cysteine synthase A. (304 aa)
ACZ09923.1PFAM: homocysteine S-methyltransferase; cobalamin B12-binding domain protein; Methionine synthase B12- binding module cap domain protein; dihydropteroate synthase DHPS; KEGG: gsu:GSU2921 5-methyltetrahydrofolate- homocysteine methyltransferase, truncation. (791 aa)
ACZ10121.1TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: gme:Gmet_2988 cysteine synthase. (302 aa)
ACZ10140.1Anthranilate synthase; PFAM: Chorismate binding-like; KEGG: ccv:CCV52592_1683 anthranilate synthase component 1 (anthranilate synthasecomponent I). (419 aa)
ACZ10141.1TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cff:CFF8240_0351 anthranilate synthase component II. (197 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa)
ACZ10143.1PFAM: Indole-3-glycerol phosphate synthase; KEGG: abu:Abu_0850 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (244 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: cco:CCC13826_0970 N- (5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (196 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (252 aa)
ACZ10180.1KEGG: aci:ACIAD1456 hypothetical protein. (424 aa)
pepALeucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (471 aa)
ACZ10233.1Serine acetyltransferase-like protein; KEGG: cjd:JJD26997_1249 serine acetyltransferase. (180 aa)
ACZ10282.1Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; SMART: regulatory protein LuxR; KEGG: shl:Shal_2879 LuxR family transcriptional regulator. (335 aa)
ACZ10283.1Carbamate kinase; KEGG: ecw:EcE24377A_3199 carbamate kinase; TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (312 aa)
aguAAgmatine deiminase; KEGG: pcr:Pcryo_0822 peptidyl-arginine deiminase; TIGRFAM: agmatine deiminase; PFAM: Porphyromonas-type peptidyl-arginine deiminase. (366 aa)
ACZ10285.1PFAM: amino acid permease-associated region; KEGG: pla:Plav_1143 amino acid permease-associated region. (455 aa)
ACZ10286.1KEGG: pla:Plav_1142 putrescine carbamoyltransferase; TIGRFAM: ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region. (338 aa)
ACZ10323.1PFAM: dihydrodipicolinate synthetase; KEGG: smd:Smed_3832 N-acetylneuraminate lyase. (289 aa)
ACZ10612.1KEGG: dal:Dalk_2955 histidinol phosphate phosphatase HisJ family; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; Belongs to the PHP hydrolase family. HisK subfamily. (278 aa)
ACZ10835.1TIGRFAM: aspartate racemase; PFAM: Asp/Glu/hydantoin racemase; KEGG: sse:Ssed_2728 hypothetical protein; Belongs to the aspartate/glutamate racemases family. (231 aa)
Your Current Organism:
Sebaldella termitidis
NCBI taxonomy Id: 526218
Other names: S. termitidis ATCC 33386, Sebaldella termitidis ATCC 33386, Sebaldella termitidis NCTC 11300, Sebaldella termitidis str. ATCC 33386, Sebaldella termitidis strain ATCC 33386
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