(6 nodes) MCM OB domain network (Verticillium alfalfae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VDBG_08337	DNA helicase; Belongs to the MCM family. (751 aa)
	VDBG_00239	DNA replication licensing factor mcm5; Belongs to the MCM family. (638 aa)
	VDBG_04264	DNA replication licensing factor mcm2; Belongs to the MCM family. (699 aa)
	VDBG_04551	DNA helicase; Belongs to the MCM family. (1010 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (838 aa)
	VDBG_04326	DNA helicase; Belongs to the MCM family. (869 aa)

Your Current Organism:

Verticillium alfalfae

NCBI taxonomy Id: 526221
Other names: V. alfalfae VaMs.102, Verticillium alfalfae VaMs.102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	VDBG_00239	C9SI14	C9S532	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA replication licensing factor mcm5; Belongs to the MCM family.	0.995
MCM7	VDBG_04264	C9SI14	C9SGN3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA replication licensing factor mcm2; Belongs to the MCM family.	0.999
MCM7	VDBG_04326	C9SI14	C9SJ55	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	VDBG_04551	C9SI14	C9SHL9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	VDBG_08337	C9SI14	C9STR6	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
VDBG_00239	MCM7	C9S532	C9SI14	DNA replication licensing factor mcm5; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.995
VDBG_00239	VDBG_04264	C9S532	C9SGN3	DNA replication licensing factor mcm5; Belongs to the MCM family.	DNA replication licensing factor mcm2; Belongs to the MCM family.	0.995
VDBG_00239	VDBG_04326	C9S532	C9SJ55	DNA replication licensing factor mcm5; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.995
VDBG_00239	VDBG_04551	C9S532	C9SHL9	DNA replication licensing factor mcm5; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.995
VDBG_00239	VDBG_08337	C9S532	C9STR6	DNA replication licensing factor mcm5; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.995
VDBG_04264	MCM7	C9SGN3	C9SI14	DNA replication licensing factor mcm2; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
VDBG_04264	VDBG_00239	C9SGN3	C9S532	DNA replication licensing factor mcm2; Belongs to the MCM family.	DNA replication licensing factor mcm5; Belongs to the MCM family.	0.995
VDBG_04264	VDBG_04326	C9SGN3	C9SJ55	DNA replication licensing factor mcm2; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
VDBG_04264	VDBG_04551	C9SGN3	C9SHL9	DNA replication licensing factor mcm2; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
VDBG_04264	VDBG_08337	C9SGN3	C9STR6	DNA replication licensing factor mcm2; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
VDBG_04326	MCM7	C9SJ55	C9SI14	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
VDBG_04326	VDBG_00239	C9SJ55	C9S532	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor mcm5; Belongs to the MCM family.	0.995
VDBG_04326	VDBG_04264	C9SJ55	C9SGN3	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor mcm2; Belongs to the MCM family.	0.999
VDBG_04326	VDBG_04551	C9SJ55	C9SHL9	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
VDBG_04326	VDBG_08337	C9SJ55	C9STR6	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999