(37 nodes) Papain-like cysteine peptidase superfamily network (Verticillium alfalfae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VDBG_07448	Ubiquitin thioesterase OTU1. (299 aa)
	VDBG_07511	USP domain-containing protein; Belongs to the peptidase C19 family. (1063 aa)
	VDBG_07514	USP domain-containing protein. (475 aa)
	VDBG_07756	Uncharacterized protein. (177 aa)
	VDBG_07952	Ubiquitin carboxyl-terminal hydrolase. (953 aa)
	VDBG_08312	Ubiquitin carboxyl-terminal hydrolase. (247 aa)
	VDBG_08824	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family. (2284 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1118 aa)
	VDBG_09296	DNA repair protein rhp41. (777 aa)
	VDBG_09377	Ubiquitin carboxyl-terminal hydrolase. (318 aa)
	VDBG_09735	Ubiquitin carboxyl-terminal hydrolase. (479 aa)
	VDBG_04106	U4/U6.U5 tri-snRNP-associated protein. (549 aa)
	VDBG_03414	ULP_PROTEASE domain-containing protein. (817 aa)
	VDBG_02541	Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (898 aa)
	VDBG_02537	Ubiquitin carboxyl-terminal hydrolase. (239 aa)
	VDBG_01963	Ubiquitin carboxyl-terminal hydrolase. (541 aa)
	VDBG_01804	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. (491 aa)
	VDBG_02373	Ubiquitin carboxyl-terminal hydrolase. (274 aa)
	VDBG_04154	Sentrin-specific protease. (1079 aa)
	VDBG_00155	Ubiquitin C-terminal hydrolase family protein. (746 aa)
	VDBG_00150	Cytokinesis protein Cyk3. (1246 aa)
	VDBG_01393	Uncharacterized protein. (66 aa)
	VDBG_01392	Uncharacterized protein. (512 aa)
	VDBG_00946	TGc domain-containing protein. (656 aa)
	VDBG_00592	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family. (879 aa)
	VDBG_00310	Predicted protein. (180 aa)
	VDBG_00252	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family. (1148 aa)
	VDBG_02311	Ubiquitin thioesterase OTUB1. (648 aa)
	VDBG_03487	DNA repair protein rhp42. (1024 aa)
	VDBG_04302	Calpain-5; Belongs to the peptidase C2 family. (781 aa)
	VDBG_05060	NEDD8-specific protease. (312 aa)
	VDBG_05798	Calpain-13; Belongs to the peptidase C2 family. (854 aa)
	VDBG_06701	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family. (1870 aa)
	VDBG_07071	Ubiquitinyl hydrolase 1. (528 aa)
	VDBG_07339	PNG1. (473 aa)
	VDBG_06962	PALB. (247 aa)
	VDBG_07440	Ubiquitinyl hydrolase 1. (519 aa)

Your Current Organism:

Verticillium alfalfae

NCBI taxonomy Id: 526221
Other names: V. alfalfae VaMs.102, Verticillium alfalfae VaMs.102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PAN2	VDBG_04106	C9SWJ6	C9SFQ2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...]	U4/U6.U5 tri-snRNP-associated protein.	0.497
VDBG_00155	VDBG_01963	C9S8X1	C9SBX0	Ubiquitin C-terminal hydrolase family protein.	Ubiquitin carboxyl-terminal hydrolase.	0.431
VDBG_00155	VDBG_06701	C9S8X1	C9SP76	Ubiquitin C-terminal hydrolase family protein.	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	0.532
VDBG_00155	VDBG_07071	C9S8X1	C9SQ36	Ubiquitin C-terminal hydrolase family protein.	Ubiquitinyl hydrolase 1.	0.758
VDBG_00252	VDBG_00310	C9S545	C9S5D1	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	Predicted protein.	0.608
VDBG_00252	VDBG_00592	C9S545	C9S6J3	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	0.405
VDBG_00252	VDBG_01963	C9S545	C9SBX0	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	Ubiquitin carboxyl-terminal hydrolase.	0.638
VDBG_00252	VDBG_02311	C9S545	C9S9Y9	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	Ubiquitin thioesterase OTUB1.	0.496
VDBG_00252	VDBG_04106	C9S545	C9SFQ2	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	U4/U6.U5 tri-snRNP-associated protein.	0.528
VDBG_00252	VDBG_06701	C9S545	C9SP76	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	0.578
VDBG_00252	VDBG_07071	C9S545	C9SQ36	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	Ubiquitinyl hydrolase 1.	0.778
VDBG_00252	VDBG_07448	C9S545	C9SRC3	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	Ubiquitin thioesterase OTU1.	0.495
VDBG_00252	VDBG_07511	C9S545	C9SRI6	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.724
VDBG_00252	VDBG_07952	C9S545	C9SSS7	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	Ubiquitin carboxyl-terminal hydrolase.	0.609
VDBG_00310	VDBG_00252	C9S5D1	C9S545	Predicted protein.	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	0.608
VDBG_00310	VDBG_00592	C9S5D1	C9S6J3	Predicted protein.	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	0.522
VDBG_00310	VDBG_01963	C9S5D1	C9SBX0	Predicted protein.	Ubiquitin carboxyl-terminal hydrolase.	0.537
VDBG_00310	VDBG_06701	C9S5D1	C9SP76	Predicted protein.	Ubiquitin carboxyl-terminal hydrolase; Belongs to the peptidase C19 family.	0.563
VDBG_00310	VDBG_07071	C9S5D1	C9SQ36	Predicted protein.	Ubiquitinyl hydrolase 1.	0.624
VDBG_00310	VDBG_07440	C9S5D1	C9SRB5	Predicted protein.	Ubiquitinyl hydrolase 1.	0.510