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| | Gobs_0049 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: rop:ROP_19820 hypothetical protein. (130 aa) |
| | Gobs_0052 | PFAM: metallophosphoesterase; KEGG: mgi:Mflv_4868 metallophosphoesterase. (441 aa) |
| | Gobs_0064 | PFAM: CinA domain protein; molybdopterin binding domain; KEGG: mjl:Mjls_2737 competence damage-inducible protein A; Belongs to the CinA family. (434 aa) |
| | Gobs_0073 | PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase; KEGG: rsk:RSKD131_1430 phospholipase D/transphosphatidylase. (504 aa) |
| | Gobs_0091 | PFAM: thiamine monophosphate synthase; KEGG: stp:Strop_3885 thiamine monophosphate synthase. (199 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (281 aa) |
| | Gobs_0093 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: sde:Sde_1455 hypothetical protein. (66 aa) |
| | Gobs_0094 | TIGRFAM: glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; KEGG: sgr:SGR_5394 putative glycine oxidase. (368 aa) |
| | Gobs_0096 | Transcriptional activator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP); Belongs to the TenA family. (198 aa) |
| | Gobs_0097 | PFAM: TENA/THI-4 domain protein; KEGG: npu:Npun_R3311 TenA family transcription regulator. (205 aa) |
| | Gobs_0140 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: bwe:BcerKBAB4_2400 glyoxalase/bleomycin resistance protein/dioxygenase. (143 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (570 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (501 aa) |
| | Gobs_0265 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mva:Mvan_4455 glyoxalase/bleomycin resistance protein/dioxygenase. (159 aa) |
| | Gobs_0273 | IMP dehydrogenase family protein; KEGG: tfu:Tfu_2440 inosine 5-monophosphate dehydrogenase; TIGRFAM: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; SMART: CBS domain containing protein. (477 aa) |
| | Gobs_0362 | KEGG: xca:xccb100_4118 thymidylate kinase. (209 aa) |
| | Gobs_0460 | PFAM: sugar isomerase (SIS); KEGG: sco:SCO6186 phosphoheptose isomerase. (226 aa) |
| | Gobs_0503 | PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase; KEGG: msm:MSMEG_0375 phospholipase D family protein. (546 aa) |
| | Gobs_0509 | PFAM: metallophosphoesterase; KEGG: nfa:nfa3370 hypothetical protein. (321 aa) |
| | acsA | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa) |
| | Gobs_0559 | PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; KEGG: nca:Noca_1494 phospholipid/glycerol acyltransferase. (219 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (225 aa) |
| | Gobs_0615 | KEGG: sen:SACE_0395 hypoxanthine-guanine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (195 aa) |
| | folE | KEGG: mbt:JTY_3674 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. (206 aa) |
| | Gobs_0634 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (558 aa) |
| | Gobs_0635 | KEGG: saq:Sare_4714 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (304 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (273 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (220 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (167 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | Gobs_0879 | PFAM: carboxyl transferase; KEGG: rer:RER_58860 acetyl-CoA carboxylase beta chain. (506 aa) |
| | Gobs_0885 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (480 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (321 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (498 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa) |
| | Gobs_0975 | KEGG: ace:Acel_0844 flagellar protein export ATPase FliI; TIGRFAM: flagellar protein export ATPase FliI; ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain protein; SMART: AAA ATPase. (435 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (324 aa) |
| | Gobs_1025 | KEGG: met:M446_2290 hypothetical protein. (299 aa) |
| | Gobs_1026 | PFAM: Myo-inositol-1-phosphate synthase; Myo- inositol-1-phosphate synthase GAPDH domain protein; KEGG: mch:Mchl_2906 inositol-3-phosphate synthase. (398 aa) |
| | Gobs_1185 | KEGG: rop:ROP_19820 hypothetical protein. (80 aa) |
| | Gobs_1247 | PFAM: protein of unknown function UPF0157; KEGG: cmi:CMM_0656 hypothetical protein. (197 aa) |
| | Gobs_1351 | PFAM: isochorismatase hydrolase; KEGG: tfu:Tfu_2374 putative pyrazinamidase / nicotinamidase. (191 aa) |
| | Gobs_1352 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (427 aa) |
| | idi | Isopentenyl-diphosphate delta-isomerase, type 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (190 aa) |
| | Gobs_1398 | PFAM: diacylglycerol kinase catalytic region; SMART: diacylglycerol kinase catalytic region; KEGG: sen:SACE_3293 hypothetical protein. (310 aa) |
| | Gobs_1409 | PFAM: phosphoribosyltransferase; KEGG: cms:CMS_2395 adenine phosphoribosyltransferase. (176 aa) |
| | Gobs_1439 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: fre:Franean1_7202 glyoxalase/bleomycin resistance protein/dioxygenase. (137 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (423 aa) |
| | Gobs_1560 | PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; KEGG: fre:Franean1_0164 circadian phase modifier CpmA. (236 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (247 aa) |
| | Gobs_1800 | KEGG: ach:Achl_1315 glutamine amidotransferase. (242 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (164 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (638 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (297 aa) |
| | Gobs_2218 | TIGRFAM: pyridoxal kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: met:M446_1429 pyridoxal kinase; Belongs to the pyridoxine kinase family. (283 aa) |
| | Gobs_2378 | PFAM: AMP-dependent synthetase and ligase; KEGG: tfu:Tfu_2808 putative acetyl-coenzyme A synthetase. (567 aa) |
| | Gobs_2491 | PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; KEGG: nca:Noca_0015 phospholipid/glycerol acyltransferase. (367 aa) |
| | Gobs_2619 | KEGG: kra:Krad_1970 hypothetical protein. (466 aa) |
| | Gobs_2700 | PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; KEGG: sma:SAV_1485 1-acylglycerol-3-phosphate O- acyltransferase. (286 aa) |
| | Gobs_2707 | PFAM: thymidine kinase; KEGG: stp:Strop_2343 thymidine kinase. (243 aa) |
| | coaA | TIGRFAM: pantothenate kinase; KEGG: mxa:MXAN_2325 pantothenate kinase. (320 aa) |
| | Gobs_2731 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: sen:SACE_3847 CDP-diacylglycerol--glycerol-3- phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (223 aa) |
| | purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa) |
| | purU-3 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa) |
| | cmk | TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region; KEGG: mva:Mvan_3275 cytidylate kinase. (229 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (566 aa) |
| | Gobs_3007 | PFAM: Thiamin pyrophosphokinase catalytic region; KEGG: saq:Sare_1905 thiamin pyrophosphokinase catalytic region. (395 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (344 aa) |
| | Gobs_3031 | PFAM: diacylglycerol kinase catalytic region; KEGG: aau:AAur_4154 diacylglycerol kinase catalytic subunit. (293 aa) |
| | Gobs_3125 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (203 aa) |
| | pyrF | KEGG: sco:SCO1481 orotidine 5'-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (292 aa) |
| | Gobs_3131 | PFAM: dihydroorotate oxidase; KEGG: zmo:ZMO0120 hypothetical protein. (385 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl- phosphate synthetase large chain domain protein; KEGG: sen:SACE_2083 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1101 aa) |
| | carA | KEGG: sco:SCO1484 carbamoyl phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (388 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa) |
| | pyrB | KEGG: ace:Acel_1301 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa) |
| | Gobs_3171 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (861 aa) |
| | apt | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (197 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (217 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (302 aa) |
| | Gobs_3186 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: rop:ROP_68590 phosphatidylinositol synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (218 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa) |
| | Gobs_3217 | PFAM: phosphoribosyltransferase; KEGG: cms:CMS_2395 adenine phosphoribosyltransferase. (181 aa) |
| | Gobs_3295 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: fal:FRAAL2165 CDP-diacylglycerol-inositol 3- phosphatidyltransferase. (218 aa) |
| | Gobs_3324 | PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; KEGG: sen:SACE_1702 1-acyl-sn-glycerol-3-phosphate acyltransferase. (254 aa) |
| | Gobs_3397 | PFAM: glutamine amidotransferase class-I; KEGG: stp:Strop_3336 glutamine amidotransferase class-I. (246 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (611 aa) |
| | Gobs_3459 | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (462 aa) |
| | Gobs_3663 | PFAM: NUDIX hydrolase; KEGG: bcv:Bcav_0671 NUDIX hydrolase. (154 aa) |
| | Gobs_3938 | TIGRFAM: CDP-diacylglycerol/glycerol-3-phosphate 3- phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: sen:SACE_5881 CDP-diacylglycerol--glycerol-3- phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (220 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (272 aa) |
| | Gobs_3956 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: stp:Strop_1379 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (324 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (387 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (398 aa) |
| | Gobs_3987 | PFAM: phosphatidate cytidylyltransferase; KEGG: sen:SACE_6034 phosphatidate cytidylyltransferase; Belongs to the CDS family. (348 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (261 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | Gobs_4038 | KEGG: tfu:Tfu_2391 hypothetical protein. (210 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (328 aa) |
| | Gobs_4045 | KEGG: rxy:Rxyl_0272 CDP-diacylglycerol-choline O- phosphatidyltransferase. (267 aa) |
| | gpsA | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; NADP oxidoreductase coenzyme F420-dependent; Ketopantoate reductase ApbA/PanE domain protein; KEGG: sma:SAV_2680 NAD(P)H-dependent glycerol-3- phosphate dehydrogenase. (336 aa) |
| | Gobs_4048 | PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; KEGG: stp:Strop_1265 phospholipid/glycerol acyltransferase. (271 aa) |
| | Gobs_4130 | KEGG: sen:SACE_1989 adenylate cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase. (348 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (129 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (478 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (326 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (545 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (290 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (195 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (275 aa) |
| | Gobs_4163 | KEGG: sma:SAV_7311 1-acylglycerol-3-phosphate O- acyltransferase. (241 aa) |
| | Gobs_4165 | KEGG: rha:RHA1_ro05084 adenylate cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase. (357 aa) |
| | Gobs_4177 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; 3-demethylubiquinone-9 3- methyltransferase; KEGG: bcv:Bcav_1646 glyoxalase/bleomycin resistance protein/dioxygenase. (137 aa) |
| | psd | Phosphatidylserine decarboxylase related protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (229 aa) |
| | Gobs_4179 | TIGRFAM: CDP-diacylglycerol/serine O- phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: hha:Hhal_0691 CDP-diacylglycerol--serine O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (276 aa) |
| | Gobs_4183 | PFAM: diacylglycerol kinase catalytic region; SMART: diacylglycerol kinase catalytic region; KEGG: sma:SAV_3015 hypothetical protein. (340 aa) |
| | Gobs_4235 | KEGG: sma:SAV_6261 hypothetical protein. (216 aa) |
| | Gobs_4289 | KEGG: ace:Acel_1940 putative acetyltransferase. (197 aa) |
| | Gobs_4336 | KEGG: nfa:nfa46400 hypothetical protein. (266 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (401 aa) |
| | Gobs_4386 | TIGRFAM: uracil phosphoribosyltransferase; KEGG: stp:Strop_0829 uracil phosphoribosyltransferase; Belongs to the UPRTase family. (207 aa) |
| | Gobs_4395 | KEGG: sen:SACE_6573 adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: adenosine/AMP deaminase. (358 aa) |
| | folD-2 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (289 aa) |
| | purH | KEGG: rer:RER_44230 bifunctional purine biosynthesis protein PurH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. (516 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (205 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (520 aa) |
| | Gobs_4446 | TIGRFAM: IMP dehydrogenase family protein; KEGG: stp:Strop_3836 IMP dehydrogenase family protein. (383 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (501 aa) |
| | Gobs_4470 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (397 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (155 aa) |
| | Gobs_4472 | TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain; KEGG: sgr:SGR_4299 putative molybdopterin biosynthesis protein. (165 aa) |
| | fdhD | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (276 aa) |
| | Gobs_4474 | Conserved hypothetical protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (205 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (204 aa) |
| | Gobs_4586 | PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; KEGG: sen:SACE_6955 phospholipid/glycerol acyltransferase. (302 aa) |
| | tmk-2 | Major facilitator superfamily MFS_1; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (727 aa) |
| | Gobs_4702 | PFAM: protein of unknown function DUF201; KEGG: ace:Acel_0637 hypothetical protein. (346 aa) |
| | Gobs_4738 | PFAM: metallophosphoesterase; KEGG: stp:Strop_1223 metallophosphoesterase. (513 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: fal:FRAAL0129 phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (351 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (512 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (792 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (223 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (79 aa) |
| | purC | KEGG: sen:SACE_7150 phosphoribosylaminoimidazole- succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase. (287 aa) |
| | Gobs_4771 | TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; KEGG: tfu:Tfu_3014 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | purD | KEGG: stp:Strop_0134 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP- grasp (A) domain; Phosphoribosylglycinamide synthetase, N- domain; Phosphoribosylglycinamide synthetase, C-domain; protein of unknown function DUF201; Belongs to the GARS family. (421 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (199 aa) |
| | Gobs_4794 | PFAM: diacylglycerol kinase catalytic region; SMART: diacylglycerol kinase catalytic region; KEGG: kra:Krad_3655 diacylglycerol kinase catalytic region. (307 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (196 aa) |
| | Gobs_4858 | KEGG: nca:Noca_4509 pyruvate dehydrogenase (acetyl- transferring); TIGRFAM: pyruvate dehydrogenase (acetyl- transferring) E1 component, alpha subunit; PFAM: dehydrogenase E1 component. (412 aa) |
| | Gobs_4892 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: sco:SCO1393 acetoacetyl-CoA synthetase. (666 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (326 aa) |
| | Gobs_4962 | PFAM: thiamineS protein; KEGG: saq:Sare_5047 thiamineS protein. (82 aa) |
| | Gobs_4966 | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: stp:Strop_4546 molybdopterin biosynthesis MoaE protein. (136 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (219 aa) |
| | Gobs_5051 | TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: kra:Krad_0854 phosphomethylpyrimidine kinase. (274 aa) |
| | Gobs_5074 | TIGRFAM: inositol 1-phosphate synthase; PFAM: Myo-inositol-1-phosphate synthase; Myo- inositol-1-phosphate synthase GAPDH domain protein; KEGG: fra:Francci3_4529 myo-inositol-1-phosphate synthase. (359 aa) |
| | Gobs_5076 | PFAM: protein of unknown function DUF179; KEGG: sen:SACE_7376 hypothetical protein; Belongs to the UPF0301 (AlgH) family. (187 aa) |
