STRINGSTRING
ADH62059.1 ADH62059.1 ADH62094.1 ADH62094.1 pckG pckG ADH62873.1 ADH62873.1 ADH62874.1 ADH62874.1 ADH63036.1 ADH63036.1 ADH63038.1 ADH63038.1 ADH63039.1 ADH63039.1 ADH63040.1 ADH63040.1 ADH63050.1 ADH63050.1 ADH63189.1 ADH63189.1 ADH63328.1 ADH63328.1 ADH63329.1 ADH63329.1 ADH63330.1 ADH63330.1 ADH63331.1 ADH63331.1 purU purU ADH63507.1 ADH63507.1 ppc ppc ADH63567.1 ADH63567.1 mdh mdh ADH63728.1 ADH63728.1 pdhA pdhA ADH63818.1 ADH63818.1 ADH63819.1 ADH63819.1 ADH63820.1 ADH63820.1 ADH63951.1 ADH63951.1 ADH63998.1 ADH63998.1 fumC fumC sucC sucC sucD sucD ADH64944.1 ADH64944.1 ADH64945.1 ADH64945.1
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second shell of interactors
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proteins of unknown 3D structure
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ADH62059.1E3 binding domain protein; InterPro IPR004167; KEGG: tth:TTC1530 hypothetical protein; PFAM: E3 binding domain protein; SPTR: C1XRV9 E3 binding domain protein; PFAM: e3 binding domain. (526 aa)
ADH62094.1COGs: COG1485 ATPase; InterPro IPR005654; KEGG: tth:TTC1657 putative ATP/GTP-binding integral membrane protein; PFAM: AFG1-family ATPase; SPTR: C1XRS1 Predicted ATPase, COG1485; PFAM: AFG1-like ATPase. (325 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (632 aa)
ADH62873.1KEGG: bav:BAV1833 hypothetical protein; SPTR: C1XSM2 Putative uncharacterized protein. (91 aa)
ADH62874.1COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143; KEGG: bbr:BB2891 putative lipoate-protein ligase A; PFAM: biotin/lipoate A/B protein ligase; PRIAM: Lipoate--protein ligase; SPTR: C1XSM3 Lipoate-protein ligase A; PFAM: Biotin/lipoate A/B protein ligase family. (257 aa)
ADH63036.1COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR012999:IPR013027:IPR006258:IPR004099:IPR 000815:IPR001327:IPR016156; KEGG: ttj:TTHA0233 pyruvate dehydrogenase complex, dihydrolipoamide dehydrogenase E3 component; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: C1XX76 Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, di [...] (464 aa)
ADH63038.1Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterProIPR004167:IPR001078:IPR000089:IPR003016:IPR 011053; KEGG: ttj:TTHA0232 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; biotin/lipoyl attachment domain-containing protein; SPTR: C1XX74 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; PFAM: 2-oxoacid dehydrogen [...] (476 aa)
ADH63039.1Transketolase central region; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR015941:IPR009014:IPR005475:IPR005476; KEGG: ttj:TTHA0230 2-oxoisovalerate dehydrogenase, E1 component beta subunit; PFAM: Transketolase central region; Transketolase domain protein; SPTR: C1XX73 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (324 aa)
ADH63040.13-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); COGs: COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type alpha subunit; InterPro IPR001017; KEGG: tth:TTC1757 2-oxoisovalerate dehydrogenase alpha subunit; PFAM: dehydrogenase E1 component; PRIAM: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); SPTR: C1XX72 Branched-chain alpha-keto acid dehydrogenase E1 component; PFAM: Dehydrogenase E1 component. (368 aa)
ADH63050.1Mercuric reductase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR012999:IPR013027:IPR004099:IPR011796:IPR 000815:IPR001327:IPR016156; KEGG: ttj:TTHA1153 mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: C1XX60 Mercuric reductase; TIGRFAM: mercuric reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: mercuric reductase. (457 aa)
ADH63189.1COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR014273:IPR019818:IPR001804; KEGG: gwc:GWCH70_0444 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: C1XXQ4 Isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase; isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (480 aa)
ADH63328.1InterPro IPR014314:IPR000701; KEGG: ttj:TTHA1456 succinate dehydrogenase, cytochrome subunit; PFAM: succinate dehydrogenase cytochrome b subunit; SPTR: C1XVW6 Succinate dehydrogenase subunit C; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit. (123 aa)
ADH63329.1KEGG: ttj:TTHA1455 succinate dehydrogenase, membrane subunit (SdhD); SPTR: C1XVW5 Succinate dehydrogenase subunit D; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (130 aa)
ADH63330.1COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterProIPR003952:IPR004112:IPR013027:IPR003953:IPR 014006:IPR015939:IPR011281; KEGG: ttj:TTHA1454 succinate dehydrogenase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; SPTR: C1XVW4 Succinate dehydrogenase subunit A; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; succinate dehydrogenase, flavoprotein subunit; PFAM: domain; FAD binding domain; TIGRFAM: succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgr [...] (577 aa)
ADH63331.1COGs: COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; InterProIPR001041:IPR017896:IPR012675:IPR012285:IPR 009051:IPR017900:IPR004489; KEGG: tth:TTC1089 succinate dehydrogenase iron-sulfur subunit; PRIAM: Succinate dehydrogenase; SPTR: C1XVW3 Succinate dehydrogenase subunit B; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein. (232 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
ADH63507.12-methylcitrate synthase/citrate synthase II; COGs: COG0372 Citrate synthase; InterPro IPR002020:IPR016141:IPR011278:IPR016142; KEGG: tth:TTC0978 citrate synthase; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: C1XUE1 Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family. (379 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (892 aa)
ADH63567.1Isocitrate dehydrogenase, NADP-dependent; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR001804:IPR004439:IPR019818; KEGG: rmr:Rmar_1401 isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; SPTR: C1XU73 Isocitrate dehydrogenase [NADP]; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (425 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
ADH63728.1Transketolase central region; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR009014:IPR005476:IPR005475:IPR015941; KEGG: ttj:TTHA0938 pyruvate dehydrogenase E1 component, beta subunit; PFAM: Transketolase central region; Transketolase domain protein; SMART: Transketolase central region; SPTR: C1XT03 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (335 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (346 aa)
ADH63818.1COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR011603:IPR005475:IPR001017; KEGG: ttj:TTHA0289 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component; PRIAM: Oxoglutarate dehydrogenase (succinyl-transferring); SMART: Transketolase central region; SPTR: C1XT57 2-oxoglutarate dehydrogenase E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component. (919 aa)
ADH63819.12-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa)
ADH63820.1COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR012999:IPR013027:IPR006258:IPR004099:IPR 000815:IPR001327:IPR016156; KEGG: tth:TTC1700 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: C1XT55 Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide d [...] (459 aa)
ADH63951.1Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); COGs: COG0281 Malic enzyme; InterProIPR016040:IPR012301:IPR015884:IPR012302:IPR 001891; KEGG: ttj:TTHA0520 malate dehydrogenase; PFAM: malic protein NAD-binding; malic protein domain protein; PRIAM: Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); SPTR: C1XQM3 Malic enzyme; PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain. (579 aa)
ADH63998.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
ADH64944.12-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (908 aa)
ADH64945.1Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterProIPR004167:IPR001078:IPR000089:IPR003016:IPR 011053; KEGG: ttj:TTHA0184 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; biotin/lipoyl attachment domain-containing protein; SPTR: C1XYG5 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; PFAM: 2-oxoacid dehydrogen [...] (428 aa)
Your Current Organism:
Meiothermus silvanus
NCBI taxonomy Id: 526227
Other names: M. silvanus DSM 9946, Meiothermus silvanus ATCC 700542, Meiothermus silvanus DSM 9946, Meiothermus silvanus VI-R2, Meiothermus silvanus str. DSM 9946, Meiothermus silvanus strain DSM 9946
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