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| | ADH63665.1 | Amidase, hydantoinase/carbamoylase family; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR010158:IPR002933:IPR011650; KEGG: sus:Acid_0364 amidase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: N-carbamoyl-L-amino-acid hydrolase; SPTR: C1XTG7 Amidase, hydantoinase/carbamoylase family; TIGRFAM: amidase, hydantoinase/carbamoylase family; PFAM: Peptidase family M20/M25/M40; TIGRFAM: amidase, hydantoinase/carbamoylase family. (410 aa) |
| | ADH63674.1 | Acetylornithine transaminase; COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR015424:IPR005814:IPR015421; KEGG: tth:TTC0510 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: C1XTA2 4-aminobutyrate aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (260 aa) |
| | ADH63699.1 | COGs: COG4401 Chorismate mutase; InterPro IPR008243:IPR013813; KEGG: ttj:TTHA0868 chorismate mutase; PFAM: Chorismate mutase of the AroH class; SPTR: C1XT74 Chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Chorismate mutase type I; TIGRFAM: monofunctional chorismate mutase, gram positive type, clade 1. (122 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (423 aa) |
| | ADH63594.1 | COGs: COG0527 Aspartokinase; InterProIPR001341:IPR001048:IPR018042:IPR002912:IPR 005260; KEGG: ttj:TTHA0534 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; PRIAM: Aspartate kinase; SPTR: C1XYW0 Aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (406 aa) |
| | ADH63586.1 | COGs: COG0069 Glutamate synthase domain 2; InterProIPR006982:IPR002489:IPR002932:IPR017932:IPR 000583; KEGG: ttj:TTHA1468 glutamate synthase, large subunit; PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase; glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: C1XYW8 Glutamate synthase (Ferredoxin); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1518 aa) |
| | mtnA | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (329 aa) |
| | ADH63499.1 | COGs: COG0287 Prephenate dehydrogenase; InterPro IPR016040:IPR003099:IPR002912; KEGG: ttj:TTHA0799 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydrogenase; SPTR: C1XUE9 Prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; ACT domain. (360 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa) |
| | ADH63489.1 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (352 aa) |
| | ilvD | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR000581:IPR020558:IPR004404; KEGG: ttj:TTHA1234 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: C1XUG4 Dihydroxyacid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (554 aa) |
| | ADH63484.1 | Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR017439:IPR010168:IPR011650:IPR002933; KEGG: cya:CYA_2514 M20D family peptidase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Aminoacylase; SPTR: C1XUG6 Amidohydrolase; TIGRFAM: amidohydrolase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (399 aa) |
| | ADH63254.1 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR018488:IPR019811:IPR016040:IPR005106:IPR 001342; KEGG: ttj:TTHA0489 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; PRIAM: Homoserine dehydrogenase; SPTR: C1XW41 Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain. (339 aa) |
| | ADH63253.1 | COGs: COG0498 Threonine synthase; InterPro IPR001926:IPR000634:IPR004450; KEGG: rmr:Rmar_1263 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: C1XW42 Threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (428 aa) |
| | ADH63230.1 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR019818:IPR001804; KEGG: ttj:TTHA1378 homoisocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: C1XXL0 Homoisocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: 3-isopropylmalate dehydrogenase; isopropylmalate/isohomocitrate dehydrogenases. (334 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (383 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (219 aa) |
| | ADH63222.1 | COGs: COG0337 3-dehydroquinate synthetase; InterPro IPR002658:IPR016303; KEGG: tth:TTC1020 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase; PRIAM: 3-dehydroquinate synthase; SPTR: C1XXL8 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase; TIGRFAM: 3-dehydroquinate synthase. (351 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (124 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (152 aa) |
| | ADH63189.1 | COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR014273:IPR019818:IPR001804; KEGG: gwc:GWCH70_0444 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: C1XXQ4 Isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase; isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (480 aa) |
| | ADH63183.1 | COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277:IPR015424:IPR015422:IPR015421; KEGG: tro:trd_A0675 methionine gamma-lyase (L-methioninase); PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cystathionine gamma-lyase; SPTR: C1XXR0 Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. (388 aa) |
| | mqnB | Futalosine nucleosidase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (223 aa) |
| | trpF | COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR013785:IPR011060:IPR001240; KEGG: tth:TTC1929 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: C1XXV7 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (206 aa) |
| | ADH63064.1 | NHL repeat containing protein; InterPro IPR001258:IPR011042; KEGG: gau:GAU_0392 hypothetical protein; PFAM: NHL repeat containing protein; SPTR: C1XYP6 Gluconolactonase. (950 aa) |
| | ADH63034.1 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR010140:IPR016195:IPR004013; KEGG: tth:TTC1652 histidinol-phosphatase; PFAM: PHP domain protein; SPTR: C1XX78 Histidinol-phosphate phosphatase; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. (262 aa) |
| | ADH62992.1 | COGs: COG0031 Cysteine synthase; InterProIPR005856:IPR001926:IPR000634:IPR001216:IPR 005859; KEGG: tth:TTC1636 cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: C1XXC3 Cysteine synthase; TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | ADH62885.1 | COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR015421:IPR015424:IPR020578:IPR000192; KEGG: ttj:TTHA0173 aminotransferase, class V; PFAM: aminotransferase class V; SPTR: C1XSN5 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase; PFAM: Aminotransferase class-V. (379 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (290 aa) |
| | ADH62807.1 | Peptidase M20; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR002933:IPR011650:IPR017150; KEGG: tth:TTC1334 carboxypeptidase G2 precursor; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: C1XSF2 Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain. (372 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (142 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (335 aa) |
| | ADH62696.1 | Iron sulfur domain-containing, CDGSH-type; InterPro IPR018967; KEGG: tth:TTC1970 hypothetical protein; PFAM: Iron sulphur domain-containing, CDGSH-type; SPTR: C1XST1 Iron-binding zinc finger protein, CDGSH type; PFAM: Iron-binding zinc finger CDGSH type. (76 aa) |
| | ADH62678.1 | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (226 aa) |
| | hisZ | Histidine--tRNA ligase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (386 aa) |
| | ADH62579.1 | Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: phe:Phep_2045 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: C1XWE0 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; PFAM: Aminotransferase class IV. (280 aa) |
| | ADH62542.1 | Iron sulfur domain-containing, CDGSH-type; InterPro IPR018967; KEGG: tth:TTC0943 hypothetical protein; PFAM: Iron sulphur domain-containing, CDGSH-type; SPTR: C1XWI6 Uncharacterized conserved protein; PFAM: Iron-binding zinc finger CDGSH type. (68 aa) |
| | ADH62402.1 | Quinone oxidoreductase, YhdH/YhfP family; COGs: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductase; InterProIPR016040:IPR013149:IPR011032:IPR013154:IPR 014188; KEGG: rrs:RoseRS_3205 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; SPTR: C1XY77 Putative quinone oxidoreductase, YhdH/YhfP family; TIGRFAM: quinone oxidoreductase, YhdH/YhfP family; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: putative quinone oxidoreductase, YhdH/YhfP family. (325 aa) |
| | ADH65009.1 | COGs: COG2008 Threonine aldolase; InterPro IPR015424:IPR015422:IPR001597:IPR015421; KEGG: tth:TTC0397 L-allo-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Threonine aldolase; SPTR: C1XVC2 L-threonine aldolase; PFAM: Beta-eliminating lyase. (338 aa) |
| | ADH64867.1 | GCN5-related N-acetyltransferase; InterPro IPR000182:IPR016181; KEGG: tth:TTC1955 acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: C1XUY9 Acetyltransferase; PFAM: Acetyltransferase (GNAT) family. (297 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (330 aa) |
| | ADH64796.1 | Glycine C-acetyltransferase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR015424:IPR004839:IPR015421; KEGG: cag:Cagg_0385 glycine C-acetyltransferase; PFAM: aminotransferase class I and II; PRIAM: Glycine C-acetyltransferase; SPTR: C1XV63 2-amino-3-ketobutyrate coenzyme A ligase; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase. (410 aa) |
| | ADH64763.1 | Aminotransferase class-III; COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR015424:IPR005814:IPR015421; KEGG: tro:trd_1080 aminotransferase, class III; PFAM: aminotransferase class-III; SPTR: C1XV97 Aminotransferase; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa) |
| | ADH64712.1 | Alcohol dehydrogenase zinc-binding domain protein; COGs: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductase; InterPro IPR013149:IPR016040:IPR011032:IPR013154; KEGG: ttj:TTHA0466 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; SPTR: C1XTL8 Zn-dependent oxidoreductase, NADPH:quinone reductase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. (342 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (276 aa) |
| | ADH64654.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (313 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (323 aa) |
| | ADH64652.1 | COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: ddr:Deide_11680 putative glycosyltransferase; PFAM: glycosyl transferase group 1; SPTR: C1XTU4 Glycosyltransferase; PFAM: Starch synthase catalytic domain; Glycosyl transferases group 1. (424 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (380 aa) |
| | ADH64595.1 | Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterProIPR016040:IPR017476:IPR014027:IPR014026:IPR 013328:IPR008927:IPR001732; KEGG: sus:Acid_6697 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: C1XU07 Nucleotide sugar dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central doma [...] (475 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (383 aa) |
| | hisC | COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterProIPR015421:IPR001917:IPR015424:IPR005861:IPR 004839; KEGG: ttj:TTHA0428 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: C1XP21 Histidinol phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (352 aa) |
| | hisB | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR020565:IPR020568:IPR000807; KEGG: tth:TTC0061 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: C1XP22 Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (211 aa) |
| | ADH64415.1 | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (409 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa) |
| | ADH64413.1 | Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198:IPR016040:IPR002347; KEGG: ter:Tery_4543 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: C1XP79 Putative uncharacterized protein; PFAM: short chain dehydrogenase. (249 aa) |
| | ADH64412.1 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa) |
| | ADH64411.1 | COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterProIPR016035:IPR014043:IPR004410:IPR016036:IPR 001227; KEGG: ttj:TTHA0416 malonyl CoA-[acyl carrier protein] transacylase; PFAM: Acyl transferase; SPTR: C1XP82 (Acyl-carrier-protein) S-malonyltransferase; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase. (304 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (333 aa) |
| | hisA | COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR013785:IPR011060:IPR006063:IPR006062; KEGG: ttj:TTHA1165 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR: C1XP87 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: His [...] (233 aa) |
| | ADH64379.1 | Alcohol dehydrogenase zinc-binding domain protein; COGs: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductase; InterPro IPR016040:IPR013149:IPR011032:IPR013154; KEGG: dge:Dgeo_0753 zinc-binding alcohol dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; SPTR: C1XPB4 Zn-dependent oxidoreductase, NADPH:quinone reductase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. (322 aa) |
| | ADH64362.1 | Peptidase M20; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR001261:IPR011650:IPR002933; KEGG: ttj:TTHA1351 M20/M25/M40 family peptidase; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: C1XPD4 Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain. (337 aa) |
| | ADH64355.1 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR013221:IPR004101:IPR001645; KEGG: ttj:TTHA1340 folyl-polyglutamate synthetase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; PRIAM: Tetrahydrofolate synthase; SPTR: C1XPE1 Folylpolyglutamate synthase/dihydrofolate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase. (389 aa) |
| | ADH64343.1 | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR004809:IPR014746:IPR008146; KEGG: ttj:TTHA1329 glutamine synthetase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: C1XPF3 L-glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (446 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa) |
| | ADH64316.1 | Fumarate lyase; COGs: COG0165 Argininosuccinate lyase; InterPro IPR000362:IPR008948:IPR020557:IPR003031; KEGG: ddr:Deide_1p00670 putative argininosuccinate lyase; PFAM: fumarate lyase; SPTR: C1XPI0 Argininosuccinate lyase; PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (480 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | ADH64261.1 | COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR015424:IPR005814:IPR015421; KEGG: rrs:RoseRS_4570 aminotransferase class-III; PFAM: aminotransferase class-III; SPTR: C1XPN8 4-aminobutyrate aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa) |
| | ADH64256.1 | COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR015424:IPR004632:IPR005814:IPR015421; KEGG: pfs:PFLU4036 putative 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; PRIAM: (S)-3-amino-2-methylpropionate transaminase; SPTR: C1XPP3 4-aminobutyrate aminotransferase; TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (430 aa) |
| | ADH64243.1 | COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterProIPR020578:IPR015422:IPR015424:IPR000192:IPR 015421; KEGG: tth:TTC0213 soluble hydrogenase, small subunit; PFAM: aminotransferase class V; SPTR: C1XPQ6 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase; PFAM: Aminotransferase class-V. (355 aa) |
| | ADH64242.1 | COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterProIPR016040:IPR006140:IPR002912:IPR006236:IPR 006139; KEGG: tth:TTC0586 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: C1XPQ7 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic do [...] (521 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (422 aa) |
| | argG | COGs: COG0137 Argininosuccinate synthase; InterPro IPR018223:IPR001518:IPR014729; KEGG: ttj:TTHA0284 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: C1XPT4 Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (397 aa) |
| | ADH64218.1 | GCN5-related N-acetyltransferase; InterPro IPR000182:IPR016181; KEGG: hypothetical protein; PFAM: GCN5-related N-acetyltransferase; SPTR: C1XPT5 Acetyltransferase, N-acetylglutamate synthase; PFAM: Acetyltransferase (GNAT) family. (160 aa) |
| | argH | COGs: COG0165 Argininosuccinate lyase; InterProIPR020557:IPR008948:IPR000362:IPR009049:IPR 003031; KEGG: ttj:TTHA0283 argininosuccinate lyase; PFAM: fumarate lyase; SPTR: C1XPT6 Argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (464 aa) |
| | ADH64216.1 | GCN5-related N-acetyltransferase; COGs: COG1246 N-acetylglutamate synthase and related acetyltransferase; InterPro IPR000182:IPR016181; KEGG: ttj:TTHA0282 acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: C1XPT7 N-acetylglutamate synthase; PFAM: Acetyltransferase (GNAT) family; Belongs to the acetyltransferase family. (180 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR001317:IPR006274:IPR017926:IPR002474:IPR 011702:IPR006220:IPR000991; KEGG: ttj:TTHA0280 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: C1XPT9 Carbamoyl-phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (388 aa) |
| | ADH64211.1 | Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG1171 Threonine dehydratase; InterPro IPR000634:IPR001926; KEGG: ttj:TTHA0279 putative threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: C1XPU2 L-threonine ammonia-lyase; PFAM: Pyridoxal-phosphate dependent enzyme. (304 aa) |
| | ADH64185.1 | 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein; COGs: COG0332 3-oxoacyl-(acyl-carrier-protein); InterPro IPR013747:IPR016039:IPR016038:IPR013751; KEGG: tth:TTC0343 hypothetical protein; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; SPTR: C1XPW8 3-oxoacyl-(Acyl-carrier-protein) synthase III; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III. (336 aa) |
| | dapA | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (313 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR013816:IPR006275:IPR005480:IPR013817:IPR 005479:IPR016185:IPR005483:IPR005481:IPR011761; KEGG: ttj:TTHA0612 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: C1XQ23 Carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Car [...] (1030 aa) |
| | ADH64104.1 | COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; InterPro IPR002220:IPR020625:IPR013785; KEGG: ttj:TTHA0737 putative dihidrodipicolinate synthase; PFAM: dihydrodipicolinate synthetase; SPTR: C1XQ60 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (287 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa) |
| | ADH64088.1 | Aminotransferase class-III; COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814:IPR015424:IPR015421; KEGG: tth:TTC0553 ornithine aminotransferase; PFAM: aminotransferase class-III; SPTR: C1XK59 Ornithine/acetylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (411 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | hisI | phosphoribosyl-ATP diphosphatase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR008179:IPR002496; KEGG: ttj:TTHA1445 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; SPTR: C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; b [...] (215 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | ADH64026.1 | COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR013798:IPR013785:IPR011060:IPR001468; KEGG: ttj:TTHA1164 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: C1XQE2 Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | ADH64024.1 | Hypothetical protein; InterPro IPR008969; KEGG: bcj:BCAS0321 hypothetical glycine-rich autotransporter protein; SPTR: C1XQE4 Putative uncharacterized protein. (411 aa) |
| | ADH64016.1 | Acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR012846:IPR012001:IPR012000:IPR011766:IPR 000399; KEGG: tth:TTC0852 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: C1XJ74 Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-termi [...] (562 aa) |
| | ADH64015.1 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR004789:IPR019455; KEGG: ttj:TTHA1212 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: C1XQF5 Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (170 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (519 aa) |
| | ADH64011.1 | 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterProIPR005675:IPR013709:IPR000891:IPR013785:IPR 002034; KEGG: tth:TTC0847 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; SPTR: C1XQF9 2-isopropylmalate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family prote [...] (528 aa) |
| | ADH63981.1 | FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterProIPR009051:IPR017896:IPR013027:IPR012285:IPR 000759; KEGG: gyc:GYMC61_2212 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: C1XQJ4 Glutamate synthase (NADPH) small subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase. (445 aa) |
| | ADH63963.1 | Chorismate mutase; COGs: COG0077 Prephenate dehydratase; InterPro IPR001086:IPR002912; KEGG: ttj:TTHA1104 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; PRIAM: Chorismate mutase; SPTR: C1XQL1 Prephenate dehydratase; PFAM: Prephenate dehydratase; ACT domain. (280 aa) |
| | ADH63949.1 | Peptidase M20; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR011650:IPR002933; KEGG: ttj:TTHA0509 N-acyl-L-amino acid amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: C1XQM5 Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain. (440 aa) |
| | ADH63899.1 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (173 aa) |
| | ADH63882.1 | Peptidase M20; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR011650:IPR002933; KEGG: ttj:TTHA1130 ArgE/DapE/Acy1 family peptidase; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: C1XQU3 Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain. (451 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (388 aa) |
| | ADH63847.1 | COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: ddr:Deide_09660 putative lipopolysaccharide biosynthesis protein (glycosyltranferase); PFAM: glycosyl transferase group 1; SPTR: C1XT26 Glycosyltransferase; PFAM: Glycosyl transferases group 1. (361 aa) |
| | ADH63822.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1223 aa) |
| | ADH63814.1 | KEGG: ttj:TTHA1426 hypothetical protein; SPTR: C1XT61 Putative uncharacterized protein. (240 aa) |
| | ADH63744.1 | Amidase, hydantoinase/carbamoylase family; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR011650:IPR010158:IPR002933; KEGG: rxy:Rxyl_0221 amidase, hydantoinase/carbamoylase; PFAM: peptidase M20; PRIAM: N-carbamoyl-L-amino-acid hydrolase; SPTR: C1XSY6 Amidase, hydantoinase/carbamoylase family; TIGRFAM: amidase, hydantoinase/carbamoylase family; PFAM: Peptidase family M20/M25/M40; TIGRFAM: amidase, hydantoinase/carbamoylase family. (413 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa) |
| | ADH62401.1 | Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198:IPR016040:IPR002347; KEGG: dge:Dgeo_2403 gluconate 5-dehydrogenase; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: C1XY80 Putative uncharacterized protein; PFAM: short chain dehydrogenase. (258 aa) |
| | ADH62385.1 | Pyruvate carboxyltransferase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR002034:IPR013785; KEGG: hypothetical protein; PFAM: pyruvate carboxyltransferase; SPTR: C1XQW7 Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. (413 aa) |
| | leuC | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (423 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (166 aa) |
| | ADH62378.1 | Lysine biosynthesis enzyme LysX; COGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterProIPR011870:IPR016185:IPR013651:IPR004666:IPR 011761; KEGG: ttj:TTHA1907 lysine biosynthesis enzyme LysX; PFAM: RimK domain protein ATP-grasp; SPTR: C1XQX4 L-2-aminoadipate N-acetyltransferase; TIGRFAM: lysine biosynthesis enzyme LysX; alpha-L-glutamate ligase, RimK family; PFAM: RimK-like ATP-grasp domain; TIGRFAM: Lysine biosynthesis enzyme LysX; alpha-L-glutamate ligases, RimK family; Belongs to the RimK family. (281 aa) |
| | lysY | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of [LysW]- aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (344 aa) |
| | lysZ | Acetylglutamate kinase; Catalyzes the phosphorylation of LysW-gamma-alpha- aminoadipate; Belongs to the acetylglutamate kinase family. LysZ subfamily. (269 aa) |
| | ADH62290.1 | COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: ttj:TTHA1749 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (FolK); PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR: C1XR66 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydro [...] (175 aa) |
| | lysJ | Acetylornithine and succinylornithine aminotransferase; Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (395 aa) |
| | lysK | N-acetyl-ornithine/N-acetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine. (366 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (469 aa) |
| | ADH62282.1 | Glutamine amidotransferase of anthranilate synthase; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR001317:IPR017926:IPR011702:IPR006220:IPR 000991:IPR006221; KEGG: ttj:TTHA1843 anthranilate synthase component II; PFAM: glutamine amidotransferase class-I; SPTR: C1XR74 Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (229 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (346 aa) |
| | ADH62266.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (373 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (394 aa) |
| | ADH62252.1 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (118 aa) |
| | ADH62251.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (272 aa) |
| | ADH62250.1 | Short-chain dehydrogenase/reductase SDR; COGs: COG0623 Enoyl-(acyl-carrier-protein); InterPro IPR016040:IPR002198:IPR002347; KEGG: ttj:TTHA0304 enoyl-[acyl carrier protein] reductase; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: C1XRA7 Enoyl-(Acyl-carrier-protein) reductase (NADH); PFAM: short chain dehydrogenase. (263 aa) |
| | ADH62223.1 | Alcohol dehydrogenase zinc-binding domain protein; COGs: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductase; InterPro IPR016040:IPR013149:IPR011032:IPR013154; KEGG: tth:TTC1833 quinone oxidoreductase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; SPTR: C1XRD6 Zn-dependent oxidoreductase, NADPH:quinone reductase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. (320 aa) |
| | ADH62146.1 | ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; COGs: COG0439 Biotin carboxylase; InterPro IPR013815:IPR003135:IPR011761; KEGG: rca:Rcas_4094 biotin carboxylase-like protein; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; SPTR: C1XRL5 Biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain. (388 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (293 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (425 aa) |
| | ADH62041.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa) |
| | ADH62023.1 | COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR011650:IPR002933:IPR010182:IPR001261; KEGG: rxy:Rxyl_2475 acetylornithine deacetylase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Succinyl-diaminopimelate desuccinylase; SPTR: C1XS00 Acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: acetylornithine deacetylase or succinyl-di [...] (404 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (206 aa) |
| | ADH62016.1 | COGs: COG1171 Threonine dehydratase; InterPro IPR001926:IPR002912:IPR005789; KEGG: cag:Cagg_0043 threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; SPTR: C1XS07 L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine dehydratase, medium form. (410 aa) |
| | ADH61994.1 | InterPro IPR000182:IPR016181; KEGG: smt:Smal_0855 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: C1XS32 Acetyltransferase (GNAT) family protein; PFAM: Acetyltransferase (GNAT) family. (165 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (319 aa) |
| | ADH61982.1 | Peptidase M20; COGs: COG4187 Arginine degradation protein (predicted deacylase); InterPro IPR002933:IPR011650:IPR012166; KEGG: oan:Oant_3500 peptidase M20; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: C1XS44 Arginine degradation protein (Predicted deacylase); PFAM: Peptidase family M20/M25/M40. (530 aa) |
| | ADH63662.1 | Amidase, hydantoinase/carbamoylase family; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR011650:IPR010158:IPR002933; KEGG: dge:Dgeo_2610 allantoate amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; PRIAM: Allantoate deiminase; SPTR: C1XTH0 Amidase, hydantoinase/carbamoylase family; TIGRFAM: amidase, hydantoinase/carbamoylase family; PFAM: Peptidase family M20/M25/M40; TIGRFAM: amidase, hydantoinase/carbamoylase family. (407 aa) |
