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| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa) |
| | ADH62017.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (405 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | cmk | COGs: COG0283 Cytidylate kinase; InterPro IPR011994:IPR003136; KEGG: ttj:TTHA0458 cytidylate kinase; PFAM: cytidylate kinase region; SPTR: C1XRU9 Cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase. (222 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (138 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (381 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (239 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (400 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (293 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa) |
| | ADH62140.1 | KEGG: ttj:TTHA0179 hypothetical protein; SPTR: C1XRM1 Putative uncharacterized protein. (231 aa) |
| | ADH62146.1 | ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; COGs: COG0439 Biotin carboxylase; InterPro IPR013815:IPR003135:IPR011761; KEGG: rca:Rcas_4094 biotin carboxylase-like protein; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; SPTR: C1XRL5 Biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain. (388 aa) |
| | ADH62165.1 | IMP dehydrogenase/GMP reductase; InterPro IPR001093:IPR013785:IPR015875; KEGG: lsa:LSA0276 inosine 5'-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; SPTR: C1XRJ6 IMP dehydrogenase/GMP reductase; PFAM: IMP dehydrogenase / GMP reductase domain. (370 aa) |
| | gmhA | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (191 aa) |
| | ADH62217.1 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (289 aa) |
| | ADH62275.1 | COGs: COG0314 Molybdopterin converting factor large subunit; InterProIPR003448:IPR012675:IPR003749:IPR016155:IPR 010038:IPR010034; KEGG: tth:TTC1947 molybdopterin (MPT) converting factor, subunit 2; PFAM: molybdopterin biosynthesis MoaE protein; thiamineS protein; SPTR: C1XR81 Molybdopterin synthase subunit MoaE; molybdopterin synthase subunit MoaD; TIGRFAM: molybdopterin converting factor, subunit 1; MoaD family protein; PFAM: ThiS family; MoaE protein; TIGRFAM: MoaD family protein, archaeal; molybdopterin converting factor, subunit 1, non-archaeal. (233 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (254 aa) |
| | ADH62301.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (407 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (436 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (265 aa) |
| | ADH62310.1 | Thiamine biosynthesis protein ThiS; InterPro IPR003749:IPR012675:IPR016155:IPR010035; KEGG: ttj:TTHA0675 putative thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; SPTR: C1XR46 Thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS. (68 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (208 aa) |
| | ADH62372.1 | COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123:IPR004552; KEGG: tth:TTC0983 putative acyltransferase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; SPTR: C1XQY0 1-acyl-sn-glycerol-3-phosphate acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases. (212 aa) |
| | ADH62404.1 | InterPro IPR004360; KEGG: sro:Sros_5397 hypothetical protein; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: C1XY75 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. (145 aa) |
| | ADH62415.1 | KEGG: tth:TTC1474 putative cytoplasmic protein; SPTR: C1XY64 Putative uncharacterized protein. (240 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (407 aa) |
| | ADH62534.1 | Fumble domain protein; COGs: COG5146 Pantothenate kinase acetyl-CoA regulated; InterPro IPR008040:IPR011602; KEGG: gau:GAU_3146 hypothetical protein; PFAM: Fumble domain protein; Hydantoinaseoxoprolinase domain protein; SPTR: C1XWJ5 Pantothenate kinase, acetyl-CoA regulated; PFAM: Fumble; TIGRFAM: pantothenate kinase, eukaryotic/staphyloccocal type. (278 aa) |
| | ADH62641.1 | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (324 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (182 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (205 aa) |
| | ADH62666.1 | Metal dependent phosphohydrolase; COGs: COG1713 HD superfamily hydrolase involved in NAD metabolism; InterPro IPR005249:IPR006674:IPR003607; KEGG: tth:TTC1420 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: C1XSQ1 Metal dependent phosphohydrolase; PFAM: HD domain; TIGRFAM: conserved hypothetical protein TIGR00488. (229 aa) |
| | ADH62677.1 | Ribose-phosphate pyrophosphokinase; COGs: COG0462 Phosphoribosylpyrophosphate synthetase; InterPro IPR000836:IPR005946:IPR000842; KEGG: ttj:TTHA1549 ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; PRIAM: Ribose-phosphate diphosphokinase; SPTR: C1XSR2 Ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: ribose-phosphate pyrophosphokinase. (361 aa) |
| | ADH62739.1 | InterPro IPR004305:IPR016084; KEGG: rxy:Rxyl_2792 TenA family transcription regulator; PFAM: TENA/THI-4 domain protein; SPTR: C1XS82 Putative transcription activator; PFAM: TENA/THI-4/PQQC family. (207 aa) |
| | ADH62774.1 | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; COGs: COG1044 UDP-3-O-(3-hydroxymyristoyl); InterPro IPR001451:IPR011004:IPR018357; KEGG: dth:DICTH_0661 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; SPTR: C1XSB8 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; TIGRFAM: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase. (332 aa) |
| | ADH62775.1 | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. Belongs to the LpxC family. (268 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (142 aa) |
| | ADH62778.1 | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (261 aa) |
| | ADH62779.1 | Glycosyl transferase family 19; InterPro IPR003835; KEGG: syf:Synpcc7942_1378 hypothetical protein; PFAM: glycosyl transferase family 19; SPTR: C1XSC3 Lipid A disaccharide synthetase; PFAM: Lipid-A-disaccharide synthetase. (389 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (209 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (275 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (158 aa) |
| | ADH62840.1 | COGs: COG1564 Thiamine pyrophosphokinase; InterPro IPR007371:IPR006282; KEGG: bbk:BARBAKC583_0128 thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic region; SPTR: C1XSI6 Thiamine pyrophosphokinase; TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, vitamin B1 binding domain; Thiamin pyrophosphokinase, catalytic domain; TIGRFAM: thiamine pyrophosphokinase. (211 aa) |
| | ADH62867.1 | COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123; KEGG: ttj:TTHA1390 acyltransferase family protein; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; SPTR: C1XSL6 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Acyltransferase. (198 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (343 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (491 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (743 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (228 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (86 aa) |
| | purC | COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR013816:IPR001636:IPR018236; KEGG: tth:TTC1151 phosphoribosylamidoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: C1XXF3 Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (235 aa) |
| | ADH62963.1 | COGs: COG0015 Adenylosuccinate lyase; InterProIPR000362:IPR003031:IPR008948:IPR020557:IPR 019468:IPR004769; KEGG: tth:TTC1149 putative adenylosuccinate lyase protein; PFAM: fumarate lyase; Adenylosuccinate lyase-like; SPTR: C1XXF2 Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (436 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (167 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (503 aa) |
| | plsY | Protein of unknown function DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (574 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (458 aa) |
| | ADH63184.1 | Protein of unknown function UPF0157; COGs: COG2320 conserved hypothetical protein; InterPro IPR007344; KEGG: ddr:Deide_3p00052 hypothetical protein; PFAM: protein of unknown function UPF0157; SPTR: C1XXQ9 Uncharacterized conserved protein; PFAM: Uncharacterised protein family (UPF0157). (375 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (361 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa) |
| | ADH63205.1 | Diacylglycerol kinase catalytic region; COGs: COG1597 Sphingosine kinase; InterPro IPR005829:IPR001206; KEGG: ddr:Deide_04630 putative diacylglycerol kinase; PFAM: diacylglycerol kinase catalytic region; SPTR: C1XXN7 Sphingosine/diacylglycerol kinase-like enzyme; PFAM: Diacylglycerol kinase catalytic domain. (318 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (224 aa) |
| | ADH63334.1 | COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020845:IPR000873; KEGG: tth:TTC0919 acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase and ligase; SPTR: C1XVW0 Acyl-CoA synthetase/AMP-acid ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme; TIGRFAM: acetoacetyl-CoA synthase. (642 aa) |
| | atpE | H+transporting two-sector ATPase E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (188 aa) |
| | atpC | H+transporting two-sector ATPase C (AC39) subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (325 aa) |
| | atpA | H(+)-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (576 aa) |
| | atpB | H(+)-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (466 aa) |
| | atpD | V-type ATPase, D subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (223 aa) |
| | ADH63381.1 | COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123; KEGG: dge:Dgeo_2308 phospholipid/glycerol acyltransferase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; SPTR: C1XVQ8 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Acyltransferase. (228 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa) |
| | ADH63417.1 | Protein of unknown function DUF205; COGs: COG0344 membrane protein; InterPro IPR003811; KEGG: ttj:TTHA0808 hypothetical protein; PFAM: protein of unknown function DUF205; SPTR: C1XUN9 Predicted membrane protein, COG0344; PFAM: Domain of unknown function (DUF205); TIGRFAM: conserved hypothetical integral membrane protein TIGR00023; Belongs to the PlsY family. (182 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa) |
| | purD | COGs: COG0151 Phosphoribosylamine-glycine ligase; InterProIPR020559:IPR000115:IPR016185:IPR011054:IPR 020562:IPR020561:IPR020560:IPR013817:IPR013815:IPR013816:I PR011761; KEGG: tth:TTC0460 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: C1XUN4 Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribo [...] (423 aa) |
| | acsA | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa) |
| | ADH63529.1 | Metallophosphoesterase; COGs: COG1408 phosphohydrolase; InterPro IPR004843; KEGG: ddr:Deide_3p01711 putative phosphoesterase; PFAM: metallophosphoesterase; SPTR: C1XUB6 Predicted phosphohydrolase; PFAM: Calcineurin-like phosphoesterase. (249 aa) |
| | ADH63535.1 | Riboflavin biosynthesis protein RibF; COGs: COG0196 FAD synthase; InterPro IPR015865:IPR004821:IPR015864:IPR002606; KEGG: ttj:TTHA0527 riboflavin kinase/FMN adenylyltransferase; PFAM: Riboflavin kinase; FAD synthetase; SMART: Riboflavin kinase; SPTR: C1XUB0 FMN adenylyltransferase; riboflavin kinase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; cytidyltransferase-related domain; Belongs to the ribF family. (296 aa) |
| | ADH63595.1 | COGs: COG2236 phosphoribosyltransferase; InterPro IPR000836; KEGG: sti:Sthe_1633 phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: C1XYV9 Predicted phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (169 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (555 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (363 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (439 aa) |
| | pyrB | COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR006132:IPR006130:IPR006131:IPR002082; KEGG: ttj:TTHA0782 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; SPTR: C1XSX5 Aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate carbamoyltransferase; Be [...] (314 aa) |
| | ADH63821.1 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (516 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (374 aa) |
| | ADH63837.1 | Phosphatidate cytidylyltransferase; COGs: COG0575 CDP-diglyceride synthetase; InterPro IPR000374; KEGG: ttj:TTHA0857 phosphatidate cytidylyltransferase; PFAM: phosphatidate cytidylyltransferase; SPTR: C1XT37 Phosphatidate cytidylyltransferase; PFAM: Cytidylyltransferase family; Belongs to the CDS family. (275 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (234 aa) |
| | ADH63843.1 | Diacylglycerol kinase catalytic region; COGs: COG1597 Sphingosine kinase; InterPro IPR001206; KEGG: dra:DR_1363 hypothetical protein; PFAM: diacylglycerol kinase catalytic region; SMART: diacylglycerol kinase catalytic region; SPTR: C1XT30 Sphingosine/diacylglycerol kinase-like enzyme; PFAM: Diacylglycerol kinase catalytic domain. (334 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (336 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (303 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (190 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa) |
| | ADH63978.1 | Dihydropyrimidinase; COGs: COG0044 Dihydroorotase and related cyclic amidohydrolase; InterPro IPR006680:IPR011778:IPR011059; KEGG: pjd:Pjdr2_4687 dihydropyrimidinase; PFAM: amidohydrolase; SPTR: C1XQJ6 D-hydantoinase; TIGRFAM: dihydropyrimidinase; PFAM: Amidohydrolase family; TIGRFAM: D-hydantoinase; dihydroorotase, multifunctional complex type. (459 aa) |
| | fdhD | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (283 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (507 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607:IPR013982:IPR002695; KEGG: dge:Dgeo_0513 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SPTR: C1XQA7 IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase [...] (502 aa) |
| | udk | COGs: COG0572 Uridine kinase; InterPro IPR017975:IPR006083:IPR000764:IPR003593; KEGG: ttj:TTHA0578 uridine kinase; PFAM: phosphoribulokinase/uridine kinase; SMART: AAA ATPase; SPTR: C1XQ96 Uridine kinase; TIGRFAM: uridine kinase; PFAM: Phosphoribulokinase / Uridine kinase family; TIGRFAM: uridine kinase. (223 aa) |
| | tdk | COGs: COG1435 Thymidine kinase; InterPro IPR020633:IPR001267; KEGG: dge:Dgeo_0578 thymidine kinase; PFAM: thymidine kinase; PRIAM: Thymidine kinase; SPTR: C1XQ88 Thymidine kinase; PFAM: Thymidine kinase. (203 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa) |
| | ADH64100.1 | COGs: COG0818 Diacylglycerol kinase; InterPro IPR000829; KEGG: ttj:TTHA1044 diacylglycerol kinase; PFAM: diacylglycerol kinase; SPTR: C1XJH3 Diacylglycerol kinase; PFAM: Prokaryotic diacylglycerol kinase. (131 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR013816:IPR006275:IPR005480:IPR013817:IPR 005479:IPR016185:IPR005483:IPR005481:IPR011761; KEGG: ttj:TTHA0612 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: C1XQ23 Carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Car [...] (1030 aa) |
| | ADH64206.1 | Phosphoribosyltransferase; COGs: COG0503 Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; InterPro IPR000836; KEGG: ttj:TTHA1613 adenine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: C1XPU7 PRPP-binding protein, adenine/guanine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (180 aa) |
| | ADH64207.1 | Phosphoribosyltransferase; COGs: COG0503 Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; InterPro IPR000836; KEGG: ttj:TTHA1614 adenine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: C1XPU6 PRPP-binding protein, adenine/guanine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (178 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR001317:IPR006274:IPR017926:IPR002474:IPR 011702:IPR006220:IPR000991; KEGG: ttj:TTHA0280 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: C1XPT9 Carbamoyl-phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (388 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | ADH64306.1 | COGs: COG1428 Deoxynucleoside kinase; InterPro IPR002624; KEGG: dra:DR_0299 deoxyguanosine kinase/deoxyadenosine kinase subunit; PFAM: deoxynucleoside kinase; SPTR: C1XPJ0 Deoxynucleoside kinase; PFAM: Deoxynucleoside kinase. (205 aa) |
| | ADH64307.1 | COGs: COG1428 Deoxynucleoside kinase; InterPro IPR002624; KEGG: dra:DR_0298 deoxyguanosine kinase/deoxyadenosine kinase subunit; PFAM: deoxynucleoside kinase; SPTR: C1XPI9 Deoxynucleoside kinase; PFAM: Deoxynucleoside kinase. (214 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (202 aa) |
| | ADH64356.1 | Molybdenum cofactor synthesis domain protein; COGs: COG0521 Molybdopterin biosynthesis protein; InterPro IPR008284:IPR001453:IPR020817; KEGG: saf:SULAZ_0427 molybdenum cofactor biosynthesis protein; PFAM: molybdopterin binding domain; SMART: molybdopterin binding domain; SPTR: C1XPE0 Molybdopterin adenylyltransferase; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (186 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | ADH64450.1 | Putative phosphoslipase; COGs: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase; InterPro IPR001736; KEGG: tth:TTC0824 putative phosphoslipase; SPTR: C1XP39 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase. (392 aa) |
| | ADH64529.1 | InterPro IPR016155; KEGG: aca:ACP_1949 hypothetical protein; SPTR: C1XZ62 Putative uncharacterized protein. (98 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (183 aa) |
| | gpsA | COGs: COG0240 Glycerol-3-phosphate dehydrogenase; InterProIPR016040:IPR006168:IPR011128:IPR013328:IPR 008927:IPR006109; KEGG: ttj:TTHA1740 glycerol-3-phosphate dehydrogenase; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; PRIAM: Glycerol-3-phosphate dehydrogenase (NAD(P)(+)); SPTR: C1XU48 Glycerol-3-phosphate dehydrogenase; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (316 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (190 aa) |
| | pyrF | COGs: COG0284 Orotidine-5'-phosphate decarboxylase; InterProIPR018089:IPR013785:IPR001754:IPR011995:IPR 011060; KEGG: tth:TTC1381 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; PRIAM: Orotidine-5'-phosphate decarboxylase; SPTR: C1XU45 Orotidine 5'-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 2; Belongs to the OMP decarboxylase family. Type 2 subfamily. (259 aa) |
| | ADH64581.1 | Ribose-phosphate pyrophosphokinase; COGs: COG0462 Phosphoribosylpyrophosphate synthetase; InterPro IPR000836:IPR005946; KEGG: ttj:TTHA1637 ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; PRIAM: Ribose-phosphate diphosphokinase; SPTR: C1XU23 Ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: ribose-phosphate pyrophosphokinase. (308 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR010918:IPR016188:IPR004733:IPR000728; KEGG: tth:TTC1619 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: C1XTX0 Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phospho [...] (335 aa) |
| | plsY-2 | Protein of unknown function DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (205 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (211 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (183 aa) |
| | folE | COGs: COG0302 GTP cyclohydrolase I; InterPro IPR001474:IPR020602:IPR018234; KEGG: ttj:TTHA1878 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: C1XV88 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (201 aa) |
| | ADH64842.1 | COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836:IPR005904; KEGG: ttj:TTHA0220 hypoxanthine-guanine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: C1XV15 Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (330 aa) |
| | ADH64866.1 | Diacylglycerol kinase catalytic region; COGs: COG1597 Sphingosine kinase; InterPro IPR005218:IPR001206; KEGG: tth:TTC1957 protein BmrU; PFAM: diacylglycerol kinase catalytic region; SMART: diacylglycerol kinase catalytic region; SPTR: C1XUZ0 Putative uncharacterized protein; PFAM: Diacylglycerol kinase catalytic domain; TIGRFAM: conserved protein of unknown function cotranscribed with Bmr (bmrU). (292 aa) |
| | ADH64945.1 | Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterProIPR004167:IPR001078:IPR000089:IPR003016:IPR 011053; KEGG: ttj:TTHA0184 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; biotin/lipoyl attachment domain-containing protein; SPTR: C1XYG5 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; PFAM: 2-oxoacid dehydrogen [...] (428 aa) |
| | ADH65001.1 | Molybdenum cofactor synthesis domain protein; COGs: COG0521 Molybdopterin biosynthesis protein; InterPro IPR001453:IPR020817; KEGG: ttj:TTHA0341 molybdopterin biosynthesis enzyme, MoaB; PFAM: molybdopterin binding domain; SMART: molybdopterin binding domain; SPTR: C1XVD0 Molybdopterin adenylyltransferase; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (161 aa) |
