(38 nodes) Mixed, incl. Common Pathway of Fibrin Clot Formation, and Dissolution of Fibrin Clot network (Austrofundulus limnaeus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	serpinc1	antithrombin-III; Belongs to the serpin family. (447 aa)
	LOC106510984	Leukocyte elastase inhibitor-like; Belongs to the serpin family. (379 aa)
	LOC106511452	Coagulation factor X-like. (510 aa)
	LOC106512819	Coagulation factor X-like. (123 aa)
	LOC106514564	Protein AMBP-like. (354 aa)
	LOC106514565	Protein AMBP-like; Belongs to the calycin superfamily. Lipocalin family. (206 aa)
	LOC106517630	Coagulation factor VII-like. (450 aa)
	LOC106517631	Coagulation factor VII-like. (405 aa)
	LOC106518721	Coagulation factor X-like; Belongs to the peptidase S1 family. (419 aa)
	hpx	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (424 aa)
	fgg	Fibrinogen gamma chain. (431 aa)
	serpind1	Heparin cofactor 2; Belongs to the serpin family. (505 aa)
	plat	Tissue-type plasminogen activator isoform X1. (609 aa)
	LOC106520092	Serine protease inhibitor A3K-like; Belongs to the serpin family. (117 aa)
	LOC106521060	Protein Z-dependent protease inhibitor-like; Belongs to the serpin family. (406 aa)
	LOC106521511	Tissue factor-like. (288 aa)
	LOC106522009	Urokinase-type plasminogen activator-like isoform X1. (463 aa)
	LOC106523145	Chymase-like; Belongs to the peptidase S1 family. (251 aa)
	f9	Coagulation factor IX. (527 aa)
	LOC106526005	fetuin-B-like. (355 aa)
	LOC106526883	Thrombomodulin-like. (564 aa)
	LOC106526945	Serpin A3-5-like; Belongs to the serpin family. (426 aa)
	LOC106526959	Serpin A3-5-like; Belongs to the serpin family. (424 aa)
	LOC106526963	Complement factor H-related protein 1-like. (165 aa)
	serpine1	Plasminogen activator inhibitor 1; Belongs to the serpin family. (391 aa)
	ahsg	alpha-2-HS-glycoprotein. (356 aa)
	LOC106528480	Beta-2-glycoprotein 1-like. (364 aa)
	LOC106528479	Beta-2-glycoprotein 1-like. (351 aa)
	LOC106529235	Fibrinogen alpha chain-like. (681 aa)
	fgb	Fibrinogen beta chain. (495 aa)
	LOC106529237	Fibrinogen alpha chain-like. (217 aa)
	plg	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (801 aa)
	serpine2	Glia-derived nexin isoform X1; Belongs to the serpin family. (394 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (621 aa)
	serpinf2	Alpha-2-antiplasmin isoform X1; Belongs to the serpin family. (514 aa)
	LOC106533647	Coagulation factor V-like; Belongs to the multicopper oxidase family. (864 aa)
	LOC106533695	Plasminogen-like. (126 aa)
	LOC106534295	Vitamin K-dependent protein C-like. (437 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106510984	LOC106520092	A0A2I4AI56	A0A2I4BIC9	Leukocyte elastase inhibitor-like; Belongs to the serpin family.	Serine protease inhibitor A3K-like; Belongs to the serpin family.	0.437
LOC106510984	LOC106529235	A0A2I4AI56	A0A2I4CJ73	Leukocyte elastase inhibitor-like; Belongs to the serpin family.	Fibrinogen alpha chain-like.	0.544
LOC106510984	LOC106533695	A0A2I4AI56	A0A2I4D002	Leukocyte elastase inhibitor-like; Belongs to the serpin family.	Plasminogen-like.	0.430
LOC106510984	LOC106534295	A0A2I4AI56	A0A2I4D281	Leukocyte elastase inhibitor-like; Belongs to the serpin family.	Vitamin K-dependent protein C-like.	0.466
LOC106510984	f2	A0A2I4AI56	A0A2I4CRB0	Leukocyte elastase inhibitor-like; Belongs to the serpin family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.808
LOC106510984	fgb	A0A2I4AI56	A0A2I4CJ77	Leukocyte elastase inhibitor-like; Belongs to the serpin family.	Fibrinogen beta chain.	0.498
LOC106510984	fgg	A0A2I4AI56	A0A2I4BGR7	Leukocyte elastase inhibitor-like; Belongs to the serpin family.	Fibrinogen gamma chain.	0.494
LOC106510984	plg	A0A2I4AI56	A0A2I4CKP4	Leukocyte elastase inhibitor-like; Belongs to the serpin family.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.430
LOC106510984	serpind1	A0A2I4AI56	A0A2I4BHL7	Leukocyte elastase inhibitor-like; Belongs to the serpin family.	Heparin cofactor 2; Belongs to the serpin family.	0.458
LOC106511452	LOC106521060	A0A2I4AJL3	A0A2I4BMF1	Coagulation factor X-like.	Protein Z-dependent protease inhibitor-like; Belongs to the serpin family.	0.582
LOC106511452	LOC106521511	A0A2I4AJL3	A0A2I4BP88	Coagulation factor X-like.	Tissue factor-like.	0.731
LOC106511452	LOC106529235	A0A2I4AJL3	A0A2I4CJ73	Coagulation factor X-like.	Fibrinogen alpha chain-like.	0.463
LOC106511452	LOC106533647	A0A2I4AJL3	A0A2I4CZT7	Coagulation factor X-like.	Coagulation factor V-like; Belongs to the multicopper oxidase family.	0.540
LOC106511452	LOC106534295	A0A2I4AJL3	A0A2I4D281	Coagulation factor X-like.	Vitamin K-dependent protein C-like.	0.504
LOC106511452	f2	A0A2I4AJL3	A0A2I4CRB0	Coagulation factor X-like.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.736
LOC106511452	f9	A0A2I4AJL3	A0A2I4BZD5	Coagulation factor X-like.	Coagulation factor IX.	0.404
LOC106511452	fgb	A0A2I4AJL3	A0A2I4CJ77	Coagulation factor X-like.	Fibrinogen beta chain.	0.438
LOC106511452	fgg	A0A2I4AJL3	A0A2I4BGR7	Coagulation factor X-like.	Fibrinogen gamma chain.	0.472
LOC106511452	serpinc1	A0A2I4AJL3	A0A2I4AHY9	Coagulation factor X-like.	antithrombin-III; Belongs to the serpin family.	0.697
LOC106511452	serpind1	A0A2I4AJL3	A0A2I4BHL7	Coagulation factor X-like.	Heparin cofactor 2; Belongs to the serpin family.	0.488