(52 nodes) Mixed, incl. Regulation of systemic arterial blood pressure mediated by a chemical signal, and Acetylcholine regulates insulin secretion network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106510936	Cysteinyl leukotriene receptor 2-like. (358 aa)
	htr2b	5-hydroxytryptamine receptor 2B. (466 aa)
	LOC106512464	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (644 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (460 aa)
	LOC106513273	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (90 aa)
	agtr1	Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	oxt	Oxytocin-neurophysin 1; Belongs to the vasopressin/oxytocin family. (154 aa)
	LOC106513692	Isotocin-neurophysin IT 1-like isoform X1; Belongs to the vasopressin/oxytocin family. (205 aa)
	ptgfr	Prostaglandin F2-alpha receptor. (357 aa)
	LOC106513815	Endothelin B receptor-like; Belongs to the G-protein coupled receptor 1 family. (419 aa)
	LOC106514329	Gonadotropin-releasing hormone II receptor-like. (395 aa)
	LOC106514699	Endothelin B receptor-like; Belongs to the G-protein coupled receptor 1 family. (462 aa)
	LOC106516075	Isotocin receptor-like; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (395 aa)
	LOC106516251	Guanine nucleotide-binding protein subunit alpha-14-like. (354 aa)
	LOC106516252	Guanine nucleotide-binding protein subunit alpha-11-like. (267 aa)
	adra1b	alpha-1B adrenergic receptor. (510 aa)
	LOC106518019	Vasopressin V2 receptor-like. (353 aa)
	oxtr	Oxytocin receptor; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (394 aa)
	LOC106517997	Guanine nucleotide-binding protein G(I) subunit alpha-2. (402 aa)
	LOC106518250	Vasopressin V2 receptor-like. (358 aa)
	LOC106518979	Gonadotropin-releasing hormone II receptor-like. (421 aa)
	tbxa2r	Thromboxane A2 receptor. (364 aa)
	plcb2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1246 aa)
	LOC106521552	Guanine nucleotide-binding protein subunit alpha-11-like isoform X2. (359 aa)
	LOC106521554	Guanine nucleotide-binding protein subunit alpha-11-like. (369 aa)
	LOC106522675	Endothelin-3-like. (158 aa)
	LOC106523524	Vasopressin V1a receptor-like. (305 aa)
	gnrh2	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (84 aa)
	LOC106523807	Guanine nucleotide-binding protein subunit alpha-14-like isoform X1. (355 aa)
	LOC106523804	Guanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
	LOC106524161	Endothelin-2-like isoform X1. (159 aa)
	LOC106524272	Putative gonadotropin-releasing hormone II receptor. (400 aa)
	LOC106524760	Endothelin B receptor-like; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	plcb3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1170 aa)
	gnrh1	Progonadoliberin-1. (94 aa)
	LOC106527196	5-hydroxytryptamine receptor 2C-like. (580 aa)
	ednra	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	LOC106528393	Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
	LOC106529251	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
	LOC106530016	Endothelin B receptor-like; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	LOC106530112	Endothelin-3-like. (219 aa)
	LOC106531197	Arg8-vasotocin receptor-like. (409 aa)
	gnao1	Guanine nucleotide-binding protein G(O) subunit alpha. (354 aa)
	chrm3	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (558 aa)
	LOC106532727	Extracellular calcium-sensing receptor-like. (523 aa)
	avpr1a	Vasopressin V1a receptor; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (405 aa)
	cysltr1	Cysteinyl leukotriene receptor 1. (336 aa)
	LOC106533066	5-hydroxytryptamine receptor 2A-like. (302 aa)
	LOC106534610	Endothelin-2-like. (157 aa)
	LOC106536564	Gonadotropin-releasing hormone II receptor-like. (374 aa)
	LOC106536877	Type-2 angiotensin II receptor-like; Belongs to the G-protein coupled receptor 1 family. (416 aa)
	LOC106536960	Guanine nucleotide-binding protein G(O) subunit alpha-like. (354 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106510936	LOC106516251	A0A2I4AHY8	A0A2I4B2H3	Cysteinyl leukotriene receptor 2-like.	Guanine nucleotide-binding protein subunit alpha-14-like.	0.721
LOC106510936	LOC106516252	A0A2I4AHY8	A0A2I4B2L0	Cysteinyl leukotriene receptor 2-like.	Guanine nucleotide-binding protein subunit alpha-11-like.	0.721
LOC106510936	LOC106521552	A0A2I4AHY8	A0A2I4BPF6	Cysteinyl leukotriene receptor 2-like.	Guanine nucleotide-binding protein subunit alpha-11-like isoform X2.	0.721
LOC106510936	LOC106521554	A0A2I4AHY8	A0A2I4BPG4	Cysteinyl leukotriene receptor 2-like.	Guanine nucleotide-binding protein subunit alpha-11-like.	0.721
LOC106510936	LOC106523804	A0A2I4AHY8	A0A2I4BYJ7	Cysteinyl leukotriene receptor 2-like.	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.721
LOC106510936	LOC106523807	A0A2I4AHY8	A0A2I4BYI6	Cysteinyl leukotriene receptor 2-like.	Guanine nucleotide-binding protein subunit alpha-14-like isoform X1.	0.721
LOC106510936	LOC106528393	A0A2I4AHY8	A0A2I4CG78	Cysteinyl leukotriene receptor 2-like.	Guanine nucleotide-binding protein subunit alpha-11.	0.721
LOC106510936	cysltr1	A0A2I4AHY8	A0A2I4CWZ8	Cysteinyl leukotriene receptor 2-like.	Cysteinyl leukotriene receptor 1.	0.903
LOC106512464	LOC106516251	A0A2I4AM94	A0A2I4B2H3	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Guanine nucleotide-binding protein subunit alpha-14-like.	0.761
LOC106512464	LOC106516252	A0A2I4AM94	A0A2I4B2L0	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Guanine nucleotide-binding protein subunit alpha-11-like.	0.761
LOC106512464	LOC106521552	A0A2I4AM94	A0A2I4BPF6	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Guanine nucleotide-binding protein subunit alpha-11-like isoform X2.	0.799
LOC106512464	LOC106521554	A0A2I4AM94	A0A2I4BPG4	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Guanine nucleotide-binding protein subunit alpha-11-like.	0.789
LOC106512464	LOC106523804	A0A2I4AM94	A0A2I4BYJ7	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.799
LOC106512464	LOC106523807	A0A2I4AM94	A0A2I4BYI6	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Guanine nucleotide-binding protein subunit alpha-14-like isoform X1.	0.799
LOC106512464	LOC106528393	A0A2I4AM94	A0A2I4CG78	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Guanine nucleotide-binding protein subunit alpha-11.	0.799
LOC106513273	LOC106513692	A0A2I4APR2	A0A2I4ARI7	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.	Isotocin-neurophysin IT 1-like isoform X1; Belongs to the vasopressin/oxytocin family.	0.403
LOC106513273	LOC106514329	A0A2I4APR2	A0A2I4AU35	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.	Gonadotropin-releasing hormone II receptor-like.	0.948
LOC106513273	LOC106518979	A0A2I4APR2	A0A2I4BDS1	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.	Gonadotropin-releasing hormone II receptor-like.	0.935
LOC106513273	LOC106524272	A0A2I4APR2	A0A2I4C0D9	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.	Putative gonadotropin-releasing hormone II receptor.	0.935
LOC106513273	LOC106536564	A0A2I4APR2	A0A2I4DAQ9	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.	Gonadotropin-releasing hormone II receptor-like.	0.944