(44 nodes) Chemokine-mediated signaling pathway, and Chemokine interleukin-8-like domain network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cxcl14	C-X-C motif chemokine 14. (98 aa)
	LOC106514188	C-C chemokine receptor type 1-like; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	LOC106514187	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family. (340 aa)
	LOC106514244	C-C chemokine receptor type 1-like isoform X1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	LOC106515514	C-C motif chemokine 25-like. (99 aa)
	LOC106515534	C-C motif chemokine 20-like. (119 aa)
	LOC106516879	C-C motif chemokine 21c-like. (110 aa)
	LOC106517490	C-C chemokine receptor type 9-like; Belongs to the G-protein coupled receptor 1 family. (365 aa)
	LOC106518959	C-C chemokine receptor type 6-like; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	LOC106520002	C-C motif chemokine 4-like. (107 aa)
	LOC106520939	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (105 aa)
	LOC106520938	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (121 aa)
	ackr4	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	LOC106521077	C-X-C motif chemokine 5-like isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (187 aa)
	LOC106521577	C-C motif chemokine 25-like. (154 aa)
	LOC106521844	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (108 aa)
	LOC106522010	C-C chemokine receptor type 7-like; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	LOC106522252	C-X-C chemokine receptor type 1-like; Belongs to the G-protein coupled receptor 1 family. (388 aa)
	LOC106522254	C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	LOC106522348	C-X-C motif chemokine 9-like. (136 aa)
	LOC106522573	LOW QUALITY PROTEIN: C-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	cxcr5	C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	LOC106523704	C-C motif chemokine 3-like. (91 aa)
	cxcl12	Stromal cell-derived factor 1 isoform X1. (99 aa)
	LOC106524505	Atypical chemokine receptor 4-like; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	LOC106524538	Chemokine XC receptor 1-like; Belongs to the G-protein coupled receptor 1 family. (346 aa)
	LOC106524551	C-X-C motif chemokine. (102 aa)
	LOC106525440	C-C motif chemokine 4-like. (109 aa)
	LOC106525438	C-C motif chemokine 20-like. (92 aa)
	LOC106525716	C-X-C chemokine receptor type 1-like; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	cxcr4	C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (381 aa)
	LOC106525953	C-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	LOC106526018	C-X-C chemokine receptor type 3-like; Belongs to the G-protein coupled receptor 1 family. (337 aa)
	LOC106526017	C-X-C chemokine receptor type 3-like; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	LOC106526041	C-X-C chemokine receptor type 3-like. (385 aa)
	LOC106526779	C-C chemokine receptor type 9-like; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	ccr7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (560 aa)
	LOC106526961	C-C motif chemokine. (105 aa)
	LOC106526971	Eotaxin-like. (96 aa)
	LOC106530437	C-X-C motif chemokine. (105 aa)
	ackr3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	LOC106533239	C-C chemokine receptor type 6-like; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	ccr6	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (388 aa)
	LOC106536276	C-C motif chemokine 3-like. (94 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106514187	LOC106514244	A0A2I4ATG2	A0A2I4ATN7	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 1-like isoform X1; Belongs to the G-protein coupled receptor 1 family.	0.642
LOC106514187	LOC106517490	A0A2I4ATG2	A0A2I4B7X7	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 9-like; Belongs to the G-protein coupled receptor 1 family.	0.460
LOC106514187	LOC106520002	A0A2I4ATG2	A0A2I4BHY8	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 4-like.	0.722
LOC106514187	LOC106520938	A0A2I4ATG2	A0A2I4BLY0	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.552
LOC106514187	LOC106521077	A0A2I4ATG2	A0A2I4BMI9	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine 5-like isoform X1; Belongs to the intercrine alpha (chemokine CxC) family.	0.586
LOC106514187	LOC106521577	A0A2I4ATG2	A0A2I4BPM6	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 25-like.	0.537
LOC106514187	LOC106522010	A0A2I4ATG2	A0A2I4BRC6	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 7-like; Belongs to the G-protein coupled receptor 1 family.	0.472
LOC106514187	LOC106522252	A0A2I4ATG2	A0A2I4BSB4	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-X-C chemokine receptor type 1-like; Belongs to the G-protein coupled receptor 1 family.	0.455
LOC106514187	LOC106522254	A0A2I4ATG2	A0A2I4BSG0	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family.	0.455
LOC106514187	LOC106522573	A0A2I4ATG2	A0A2I4BTK5	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	LOW QUALITY PROTEIN: C-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family.	0.635
LOC106514187	LOC106524538	A0A2I4ATG2	A0A2I4C1G0	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	Chemokine XC receptor 1-like; Belongs to the G-protein coupled receptor 1 family.	0.906
LOC106514187	LOC106525440	A0A2I4ATG2	A0A2I4C566	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 4-like.	0.579
LOC106514187	LOC106525716	A0A2I4ATG2	A0A2I4C684	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-X-C chemokine receptor type 1-like; Belongs to the G-protein coupled receptor 1 family.	0.455
LOC106514187	LOC106525953	A0A2I4ATG2	A0A2I4C740	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family.	0.900
LOC106514187	LOC106526018	A0A2I4ATG2	A0A2I4C7C9	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-X-C chemokine receptor type 3-like; Belongs to the G-protein coupled receptor 1 family.	0.447
LOC106514187	LOC106526779	A0A2I4ATG2	A0A2I4CA94	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 9-like; Belongs to the G-protein coupled receptor 1 family.	0.460
LOC106514187	LOC106536276	A0A2I4ATG2	A0A2I4D9M2	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 3-like.	0.435
LOC106514187	ackr3	A0A2I4ATG2	A0A2I4CVB6	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.403
LOC106514187	ccr7	A0A2I4ATG2	A0A2I4CAQ9	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.440
LOC106514187	cxcl12	A0A2I4ATG2	A0A2I4BZL4	C-C chemokine receptor type 8-like; Belongs to the G-protein coupled receptor 1 family.	Stromal cell-derived factor 1 isoform X1.	0.586