(12 nodes) Wnt protein, conserved site, and Frizzled/Smoothened family membrane region network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106511763	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
	LOC106515365	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	fzd4	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (547 aa)
	fzd6	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (691 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	fzd2	Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (542 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	LOC106531582	Secreted frizzled-related protein 1-like. (305 aa)
	ryk	Tyrosine-protein kinase RYK isoform X1. (627 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	LOC106537279	Frizzled-5-like; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106511763	LOC106531582	A0A2I4AKG3	A0A2I4CSH0	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 1-like.	0.794
LOC106511763	LOC106537279	A0A2I4AKG3	A0A2I4DCZ9	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled-5-like; Belongs to the G-protein coupled receptor Fz/Smo family.	0.797
LOC106511763	fzd2	A0A2I4AKG3	A0A2I4CFH6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.799
LOC106511763	fzd4	A0A2I4AKG3	A0A2I4BP43	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.834
LOC106511763	fzd6	A0A2I4AKG3	A0A2I4BZ19	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.808
LOC106511763	ryk	A0A2I4AKG3	A0A2I4CX38	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase RYK isoform X1.	0.583
LOC106511763	wnt1	A0A2I4AKG3	A0A2I4C2Q7	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.582
LOC106511763	wnt11	A0A2I4AKG3	A0A2I4B6L6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.711
LOC106511763	wnt3a	A0A2I4AKG3	A0A2I4CYH8	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.537
LOC106511763	wnt4	A0A2I4AKG3	A0A2I4CGQ9	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.569
LOC106515365	LOC106531582	A0A2I4AYK9	A0A2I4CSH0	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 1-like.	0.820
LOC106515365	LOC106537279	A0A2I4AYK9	A0A2I4DCZ9	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled-5-like; Belongs to the G-protein coupled receptor Fz/Smo family.	0.800
LOC106515365	fzd2	A0A2I4AYK9	A0A2I4CFH6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.888
LOC106515365	fzd4	A0A2I4AYK9	A0A2I4BP43	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.812
LOC106515365	fzd6	A0A2I4AYK9	A0A2I4BZ19	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.778
LOC106515365	ryk	A0A2I4AYK9	A0A2I4CX38	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase RYK isoform X1.	0.726
LOC106515365	wnt1	A0A2I4AYK9	A0A2I4C2Q7	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.643
LOC106515365	wnt11	A0A2I4AYK9	A0A2I4B6L6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.641
LOC106515365	wnt3a	A0A2I4AYK9	A0A2I4CYH8	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.554
LOC106515365	wnt4	A0A2I4AYK9	A0A2I4CGQ9	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.603