(39 nodes) Cholesterol transport network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lcat	Phosphatidylcholine-sterol acyltransferase. (445 aa)
	LOC106518072	LIM domain and actin-binding protein 1-like. (663 aa)
	LOC106517912	LIM domain and actin-binding protein 1-like. (209 aa)
	LOC106517879	Uncharacterized protein LOC106517879. (253 aa)
	kiaa1468	lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X1. (1197 aa)
	star	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (287 aa)
	npc1l1	Niemann-Pick C1-like protein 1. (1355 aa)
	abcg4	ATP-binding cassette sub-family G member 4. (641 aa)
	LOC106513561	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (556 aa)
	LOC106513373	Xin actin-binding repeat-containing protein 1-like isoform X1. (1733 aa)
	LOC106512370	Cholesteryl ester transfer protein-like. (163 aa)
	LOC106511174	ATP-binding cassette sub-family D member 1-like. (777 aa)
	LOC106521187	Synaptotagmin-7-like isoform X1. (564 aa)
	npc2	Epididymal secretory protein E1. (148 aa)
	ldlrap1	Low density lipoprotein receptor adapter protein 1 isoform X1. (313 aa)
	vps4a	Vacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (436 aa)
	cetp	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (499 aa)
	abcg1	ATP-binding cassette sub-family G member 1. (685 aa)
	LOC106535301	ATP-binding cassette sub-family G member 5-like. (658 aa)
	arv1	Protein ARV1. (175 aa)
	abcg8	ATP-binding cassette sub-family G member 8. (666 aa)
	LOC106534304	Apolipoprotein B-100-like. (3309 aa)
	vps4b	Vacuolar protein sorting-associated protein 4B isoform X1; Belongs to the AAA ATPase family. (508 aa)
	spg11	Spatacsin. (2380 aa)
	npc1	Niemann-Pick C1 protein. (1271 aa)
	scarb1	Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (521 aa)
	LOC106531880	LIM domain and actin-binding protein 1-like isoform X1. (657 aa)
	apom	Apolipoprotein M isoform X1. (191 aa)
	LOC106530693	Synaptotagmin-7-like isoform X1. (690 aa)
	apoe	Apolipoprotein E. (251 aa)
	podn	Podocan. (593 aa)
	stard3	stAR-related lipid transfer protein 3. (456 aa)
	LOC106527805	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (550 aa)
	scp2	Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (531 aa)
	LOC106526952	Low density lipoprotein receptor adapter protein 1-A-like isoform X1. (297 aa)
	LOC106523750	Apolipoprotein Eb-like. (265 aa)
	stard3nl	MLN64 N-terminal domain homolog. (232 aa)
	apob	Apolipoprotein B-100 isoform X1. (3804 aa)
	LOC106521237	Apolipoprotein B-100-like isoform X1. (4384 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106511174	scp2	A0A2I4AIS7	A0A2I4CBT1	ATP-binding cassette sub-family D member 1-like.	Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.699
LOC106512370	LOC106521237	A0A2I4ALT6	A0A2I4BN50	Cholesteryl ester transfer protein-like.	Apolipoprotein B-100-like isoform X1.	0.601
LOC106512370	LOC106523750	A0A2I4ALT6	A0A2I4BYB0	Cholesteryl ester transfer protein-like.	Apolipoprotein Eb-like.	0.440
LOC106512370	LOC106534304	A0A2I4ALT6	A0A2I4D288	Cholesteryl ester transfer protein-like.	Apolipoprotein B-100-like.	0.601
LOC106512370	apob	A0A2I4ALT6	A0A2I4BTW0	Cholesteryl ester transfer protein-like.	Apolipoprotein B-100 isoform X1.	0.601
LOC106512370	lcat	A0A2I4ALT6	A0A2I4BIU4	Cholesteryl ester transfer protein-like.	Phosphatidylcholine-sterol acyltransferase.	0.523
LOC106513561	LOC106527805	A0A2I4AQY3	A0A2I4CE38	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.902
LOC106521237	LOC106512370	A0A2I4BN50	A0A2I4ALT6	Apolipoprotein B-100-like isoform X1.	Cholesteryl ester transfer protein-like.	0.601
LOC106521237	LOC106523750	A0A2I4BN50	A0A2I4BYB0	Apolipoprotein B-100-like isoform X1.	Apolipoprotein Eb-like.	0.780
LOC106521237	LOC106526952	A0A2I4BN50	A0A2I4CAX3	Apolipoprotein B-100-like isoform X1.	Low density lipoprotein receptor adapter protein 1-A-like isoform X1.	0.511
LOC106521237	apoe	A0A2I4BN50	A0A2I4CMA5	Apolipoprotein B-100-like isoform X1.	Apolipoprotein E.	0.702
LOC106521237	cetp	A0A2I4BN50	A0A2I4D8T7	Apolipoprotein B-100-like isoform X1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.601
LOC106521237	lcat	A0A2I4BN50	A0A2I4BIU4	Apolipoprotein B-100-like isoform X1.	Phosphatidylcholine-sterol acyltransferase.	0.438
LOC106521237	ldlrap1	A0A2I4BN50	A0A2I4BFR4	Apolipoprotein B-100-like isoform X1.	Low density lipoprotein receptor adapter protein 1 isoform X1.	0.662
LOC106521237	npc2	A0A2I4BN50	A0A2I4BKS3	Apolipoprotein B-100-like isoform X1.	Epididymal secretory protein E1.	0.566
LOC106521237	scarb1	A0A2I4BN50	A0A2I4CUA7	Apolipoprotein B-100-like isoform X1.	Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family.	0.736
LOC106523750	LOC106512370	A0A2I4BYB0	A0A2I4ALT6	Apolipoprotein Eb-like.	Cholesteryl ester transfer protein-like.	0.440
LOC106523750	LOC106521237	A0A2I4BYB0	A0A2I4BN50	Apolipoprotein Eb-like.	Apolipoprotein B-100-like isoform X1.	0.780
LOC106523750	LOC106526952	A0A2I4BYB0	A0A2I4CAX3	Apolipoprotein Eb-like.	Low density lipoprotein receptor adapter protein 1-A-like isoform X1.	0.453
LOC106523750	LOC106534304	A0A2I4BYB0	A0A2I4D288	Apolipoprotein Eb-like.	Apolipoprotein B-100-like.	0.780