(74 nodes) Ubiquitin-dependent ERAD pathway network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	wfs1	Wolframin. (960 aa)
	LOC106512241	Calreticulin. (431 aa)
	LOC106512547	Meckelin-like. (104 aa)
	ube2j2	Ubiquitin-conjugating enzyme E2 J2. (261 aa)
	march6	E3 ubiquitin-protein ligase MARCH6. (915 aa)
	ufd1l	Ubiquitin fusion degradation protein 1 homolog. (311 aa)
	LOC106514573	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (839 aa)
	LOC106514928	E3 ubiquitin-protein ligase MARCH6-like isoform X1. (922 aa)
	amfr	E3 ubiquitin-protein ligase AMFR isoform X1. (625 aa)
	LOC106515052	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (910 aa)
	tmem67	Meckelin isoform X1. (988 aa)
	rhbdd2	Rhomboid domain-containing protein 2. (294 aa)
	fam8a1	Protein FAM8A1. (298 aa)
	edem1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (672 aa)
	ttc33	Tetratricopeptide repeat protein 33. (273 aa)
	LOC106516382	RING finger protein 121. (332 aa)
	dnajb12	dnaJ homolog subfamily B member 12. (366 aa)
	dnajb14	dnaJ homolog subfamily B member 14. (377 aa)
	erlec1	Endoplasmic reticulum lectin 1. (480 aa)
	foxred2	FAD-dependent oxidoreductase domain-containing protein 2. (698 aa)
	os9	Protein OS-9 isoform X1. (662 aa)
	psmc6	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (389 aa)
	yod1	Ubiquitin thioesterase OTU1. (300 aa)
	aup1	Ancient ubiquitous protein 1. (413 aa)
	LOC106519271	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like. (726 aa)
	LOC106519313	F-box only protein 6-like. (288 aa)
	LOC106519317	F-box only protein 44-like. (301 aa)
	LOC106519314	F-box only protein 6-like. (280 aa)
	jkamp	JNK1/MAPK8-associated membrane protein isoform X1. (309 aa)
	LOC106520850	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B. (804 aa)
	vcp	Transitional endoplasmic reticulum ATPase isoform X1; Belongs to the AAA ATPase family. (810 aa)
	LOC106521872	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (226 aa)
	ube4b	Ubiquitin conjugation factor E4 B isoform X1. (1380 aa)
	ankzf1	Ankyrin repeat and zinc finger domain-containing protein 1 isoform X1. (736 aa)
	LOC106523525	dnaJ homolog subfamily B member 9-like. (234 aa)
	LOC106525017	RING finger protein 175-like. (313 aa)
	LOC106525484	dnaJ homolog subfamily B member 9-like. (217 aa)
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (249 aa)
	sec61b	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (97 aa)
	sgtb	Small glutamine-rich tetratricopeptide repeat-containing protein beta. (306 aa)
	LOC106529420	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (676 aa)
	LOC106529480	Protein FAM8A1-like. (319 aa)
	ube2g2	Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
	canx	Calnexin. (605 aa)
	LOC106530386	Transitional endoplasmic reticulum ATPase-like; Belongs to the AAA ATPase family. (809 aa)
	ubxn4	UBX domain-containing protein 4. (473 aa)
	bag6	Large proline-rich protein BAG6 isoform X1. (1202 aa)
	rnf5	E3 ubiquitin-protein ligase RNF5. (214 aa)
	LOC106531114	Wolframin-like isoform X1. (988 aa)
	vimp	Selenoprotein S. (185 aa)
	nccrp1	F-box only protein 50. (231 aa)
	syvn1	E3 ubiquitin-protein ligase synoviolin isoform X1. (628 aa)
	edem2	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (563 aa)
	kiaa0368	Proteasome-associated protein ECM29 homolog isoform X1. (1850 aa)
	faf1	FAS-associated factor 1. (674 aa)
	LOC106533491	F-box only protein 2-like. (175 aa)
	faf2	FAS-associated factor 2. (445 aa)
	LOC106533956	Calreticulin. (423 aa)
	ube4a	Ubiquitin conjugation factor E4 A isoform X1. (1080 aa)
	LOC106534123	Calmegin-like. (110 aa)
	tmub1	Transmembrane and ubiquitin-like domain-containing protein 1. (144 aa)
	ube2j1	Ubiquitin-conjugating enzyme E2 J1. (319 aa)
	rnf103	E3 ubiquitin-protein ligase RNF103 isoform X1. (675 aa)
	LOC106534457	dnaJ homolog subfamily C member 18-like. (389 aa)
	sgta	Small glutamine-rich tetratricopeptide repeat-containing protein alpha. (333 aa)
	LOC106534808	dnaJ homolog subfamily C member 10-like. (571 aa)
	LOC106534809	dnaJ homolog subfamily C member 10-like. (193 aa)
	LOC106535111	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (240 aa)
	LOC106535448	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (644 aa)
	LOC106535552	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (676 aa)
	LOC106535563	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like. (812 aa)
	clgn	Calmegin. (707 aa)
	hsp90b1	Endoplasmin. (798 aa)
	LOC106536534	dnaJ homolog subfamily B member 12-like. (372 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106512241	LOC106533956	A0A2I4ALJ4	A0A2I4D0X1	Calreticulin.	Calreticulin.	0.915
LOC106512241	LOC106534123	A0A2I4ALJ4	A0A2I4D1K1	Calreticulin.	Calmegin-like.	0.804
LOC106512241	LOC106534808	A0A2I4ALJ4	A0A2I4D452	Calreticulin.	dnaJ homolog subfamily C member 10-like.	0.800
LOC106512241	LOC106534809	A0A2I4ALJ4	A0A2I4D464	Calreticulin.	dnaJ homolog subfamily C member 10-like.	0.800
LOC106512241	canx	A0A2I4ALJ4	A0A2I4CMV5	Calreticulin.	Calnexin.	0.842
LOC106512241	clgn	A0A2I4ALJ4	A0A2I4D8A4	Calreticulin.	Calmegin.	0.842
LOC106512241	hsp90b1	A0A2I4ALJ4	A0A2I4DAK5	Calreticulin.	Endoplasmin.	0.969
LOC106512241	sec61b	A0A2I4ALJ4	A0A2I4CBE3	Calreticulin.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.527
LOC106514928	LOC106521872	A0A2I4AWQ1	A0A2I4BQR6	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.432
LOC106514928	LOC106530386	A0A2I4AWQ1	A0A2I4CN90	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	Transitional endoplasmic reticulum ATPase-like; Belongs to the AAA ATPase family.	0.619
LOC106514928	LOC106535111	A0A2I4AWQ1	A0A2I4D5E8	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.432
LOC106514928	amfr	A0A2I4AWQ1	A0A2I4AWW7	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	E3 ubiquitin-protein ligase AMFR isoform X1.	0.683
LOC106514928	derl1	A0A2I4AWQ1	A0A2I4C7G9	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.541
LOC106514928	erlec1	A0A2I4AWQ1	A0A2I4B7T9	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	Endoplasmic reticulum lectin 1.	0.477
LOC106514928	faf1	A0A2I4AWQ1	A0A2I4CW71	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	FAS-associated factor 1.	0.485
LOC106514928	faf2	A0A2I4AWQ1	A0A2I4CZI9	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	FAS-associated factor 2.	0.485
LOC106514928	march6	A0A2I4AWQ1	A0A2I4AQQ8	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	E3 ubiquitin-protein ligase MARCH6.	0.901
LOC106514928	os9	A0A2I4AWQ1	A0A2I4BA06	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	Protein OS-9 isoform X1.	0.477
LOC106514928	syvn1	A0A2I4AWQ1	A0A2I4CSW0	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	E3 ubiquitin-protein ligase synoviolin isoform X1.	0.683
LOC106514928	ube2g2	A0A2I4AWQ1	A0A2I4CMQ2	E3 ubiquitin-protein ligase MARCH6-like isoform X1.	Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.767