(37 nodes) Midbrain development network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106520874	Homeobox protein OTX2. (269 aa)
	tcf7l1	Transcription factor 7-like 1. (1077 aa)
	fst	Follistatin isoform X1. (350 aa)
	en1	Homeobox protein engrailed-like. (262 aa)
	msx1	Homeobox protein MSX-1. (287 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	LOC106517914	Cytochrome b-c1 complex subunit 8. (82 aa)
	chd8	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2620 aa)
	LOC106517635	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	LOC106517290	Cadherin-2-like isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (925 aa)
	phox2a	Paired mesoderm homeobox protein 2A. (305 aa)
	pax2	Paired box protein Pax-2 isoform X1. (415 aa)
	LOC106516405	Paired box protein Pax-5-like isoform X1. (229 aa)
	LOC106515362	Paired box protein Pax-2-A-like isoform X1. (485 aa)
	dlg5	Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (2053 aa)
	LOC106515330	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	med12	Mediator of RNA polymerase II transcription subunit 12 isoform X1. (2155 aa)
	pax8	Paired box protein Pax-8 isoform X1. (459 aa)
	LOC106513892	Diencephalon/mesencephalon homeobox protein 1-A-like isoform X1. (423 aa)
	LOC106513792	Transcription factor 7-like 1-B isoform X1. (580 aa)
	LOC106512825	Homeobox protein OTX2-A-like. (83 aa)
	LOC106534064	Cadherin-2-like; Cadherins are calcium-dependent cell adhesion proteins. (907 aa)
	LOC106535383	Diencephalon/mesencephalon homeobox protein 1-A-like. (380 aa)
	ryk	Tyrosine-protein kinase RYK isoform X1. (627 aa)
	LOC106537311	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (91 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	wdr73	WD repeat-containing protein 73. (381 aa)
	LOC106532277	Cadherin-2-like; Cadherins are calcium-dependent cell adhesion proteins. (911 aa)
	LOC106530493	Homeobox protein engrailed-like. (263 aa)
	katnb1	Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (691 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (249 aa)
	fgfr2	Fibroblast growth factor receptor. (837 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
	uchl5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	LOC106521945	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	en2	Homeobox protein engrailed-like. (268 aa)
	pax5	Paired box protein Pax-5. (425 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106512825	LOC106515330	A0A2I4AMR5	A0A2I4AYE0	Homeobox protein OTX2-A-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
LOC106515330	LOC106512825	A0A2I4AYE0	A0A2I4AMR5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein OTX2-A-like.	0.406
LOC106515330	LOC106520874	A0A2I4AYE0	A0A2I4BLJ8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein OTX2.	0.406
LOC106515330	LOC106521945	A0A2I4AYE0	A0A2I4BR01	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.408
LOC106515330	en2	A0A2I4AYE0	A0A2I4BM38	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein engrailed-like.	0.477
LOC106515330	fgf3	A0A2I4AYE0	A0A2I4C9H9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.809
LOC106515330	fgfr2	A0A2I4AYE0	A0A2I4C9D5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.940
LOC106515330	fst	A0A2I4AYE0	A0A2I4BHJ6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Follistatin isoform X1.	0.411
LOC106515330	msx1	A0A2I4AYE0	A0A2I4BBJ9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein MSX-1.	0.497
LOC106515330	wnt3a	A0A2I4AYE0	A0A2I4CYH8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.497
LOC106515362	en2	A0A2I4AYM3	A0A2I4BM38	Paired box protein Pax-2-A-like isoform X1.	Homeobox protein engrailed-like.	0.411
LOC106517290	LOC106532277	A0A2I4B6Z1	A0A2I4CUT6	Cadherin-2-like isoform X1; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin-2-like; Cadherins are calcium-dependent cell adhesion proteins.	0.900
LOC106517290	LOC106534064	A0A2I4B6Z1	A0A2I4D197	Cadherin-2-like isoform X1; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin-2-like; Cadherins are calcium-dependent cell adhesion proteins.	0.901
LOC106517635	ryk	A0A2I4B8L5	A0A2I4CX38	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase RYK isoform X1.	0.685
LOC106520874	LOC106515330	A0A2I4BLJ8	A0A2I4AYE0	Homeobox protein OTX2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.406
LOC106521945	LOC106515330	A0A2I4BR01	A0A2I4AYE0	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
LOC106521945	ryk	A0A2I4BR01	A0A2I4CX38	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase RYK isoform X1.	0.763
LOC106532277	LOC106517290	A0A2I4CUT6	A0A2I4B6Z1	Cadherin-2-like; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin-2-like isoform X1; Cadherins are calcium-dependent cell adhesion proteins.	0.900
LOC106532277	LOC106534064	A0A2I4CUT6	A0A2I4D197	Cadherin-2-like; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin-2-like; Cadherins are calcium-dependent cell adhesion proteins.	0.901
LOC106534064	LOC106517290	A0A2I4D197	A0A2I4B6Z1	Cadherin-2-like; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin-2-like isoform X1; Cadherins are calcium-dependent cell adhesion proteins.	0.901