(34 nodes) Regulation of intracellular steroid hormone receptor signaling pathway network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106511288	Histone acetyltransferase p300-like. (2265 aa)
	LOC106511698	CCR4-NOT transcription complex subunit 2-like. (145 aa)
	msc	Musculin. (159 aa)
	rnf6	E3 ubiquitin-protein ligase RNF6. (721 aa)
	znf366	Zinc finger protein 366. (245 aa)
	sirt1	NAD-dependent protein deacetylase sirtuin-1. (690 aa)
	cnot2	CCR4-NOT transcription complex subunit 2. (521 aa)
	ar	Androgen receptor. (751 aa)
	phb	Prohibitin. (271 aa)
	LOC106526691	Nuclear receptor corepressor 2-like. (175 aa)
	ncor2	Nuclear receptor corepressor 2 isoform X1. (2291 aa)
	prmt2	Protein arginine N-methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (419 aa)
	LOC106535839	Nuclear receptor subfamily 0 group B member 1-like. (298 aa)
	LOC106534944	CCR4-NOT transcription complex subunit 2-like. (529 aa)
	dab2	Disabled homolog 2 isoform X1. (739 aa)
	LOC106533460	25-hydroxycholesterol 7-alpha-hydroxylase-like; Belongs to the cytochrome P450 family. (492 aa)
	LOC106532462	Cell differentiation protein RCD1 homolog. (299 aa)
	LOC106532463	Cell differentiation protein RCD1 homolog. (105 aa)
	LOC106529544	RBR-type E3 ubiquitin transferase. (538 aa)
	kank2	KN motif and ankyrin repeat domain-containing protein 2. (1008 aa)
	cnot1	CCR4-NOT transcription complex subunit 1. (2391 aa)
	dyx1c1	Dyslexia susceptibility 1 candidate gene 1 protein. (415 aa)
	brca1	Breast cancer type 1 susceptibility protein. (1346 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1785 aa)
	ep300	Histone acetyltransferase p300. (2746 aa)
	pagr1	PAXIP1-associated glutamate-rich protein 1. (275 aa)
	vps11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (923 aa)
	rnf14	RBR-type E3 ubiquitin transferase. (481 aa)
	LOC106524050	Cell differentiation protein RCD1 homolog isoform X1. (299 aa)
	LOC106524470	Histone acetyltransferase p300-like. (1450 aa)
	tcf21	Transcription factor 21. (194 aa)
	carm1	Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (581 aa)
	LOC106525227	Androgen receptor-like isoform X1. (683 aa)
	ncor1	Nuclear receptor corepressor 1 isoform X1. (2308 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106511288	LOC106525227	A0A2I4AJ39	A0A2I4C4B7	Histone acetyltransferase p300-like.	Androgen receptor-like isoform X1.	0.581
LOC106511288	LOC106526691	A0A2I4AJ39	A0A2I4C9Z9	Histone acetyltransferase p300-like.	Nuclear receptor corepressor 2-like.	0.533
LOC106511288	ar	A0A2I4AJ39	A0A2I4B395	Histone acetyltransferase p300-like.	Androgen receptor.	0.581
LOC106511288	brca1	A0A2I4AJ39	A0A2I4B5P9	Histone acetyltransferase p300-like.	Breast cancer type 1 susceptibility protein.	0.690
LOC106511288	carm1	A0A2I4AJ39	A0A2I4C8W6	Histone acetyltransferase p300-like.	Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.844
LOC106511288	med1	A0A2I4AJ39	A0A2I4B5S3	Histone acetyltransferase p300-like.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.624
LOC106511288	ncor1	A0A2I4AJ39	A0A2I4C506	Histone acetyltransferase p300-like.	Nuclear receptor corepressor 1 isoform X1.	0.533
LOC106511288	ncor2	A0A2I4AJ39	A0A2I4C9Z5	Histone acetyltransferase p300-like.	Nuclear receptor corepressor 2 isoform X1.	0.533
LOC106511288	sirt1	A0A2I4AJ39	A0A2I4C5T8	Histone acetyltransferase p300-like.	NAD-dependent protein deacetylase sirtuin-1.	0.558
LOC106511698	LOC106524050	A0A2I4AK92	A0A2I4BZG1	CCR4-NOT transcription complex subunit 2-like.	Cell differentiation protein RCD1 homolog isoform X1.	0.878
LOC106511698	LOC106532462	A0A2I4AK92	A0A2I4CVF6	CCR4-NOT transcription complex subunit 2-like.	Cell differentiation protein RCD1 homolog.	0.878
LOC106511698	LOC106532463	A0A2I4AK92	A0A2I4CVE4	CCR4-NOT transcription complex subunit 2-like.	Cell differentiation protein RCD1 homolog.	0.878
LOC106511698	LOC106534944	A0A2I4AK92	A0A2I4D4T6	CCR4-NOT transcription complex subunit 2-like.	CCR4-NOT transcription complex subunit 2-like.	0.900
LOC106511698	cnot1	A0A2I4AK92	A0A2I4CHE5	CCR4-NOT transcription complex subunit 2-like.	CCR4-NOT transcription complex subunit 1.	0.963
LOC106511698	cnot2	A0A2I4AK92	A0A2I4B010	CCR4-NOT transcription complex subunit 2-like.	CCR4-NOT transcription complex subunit 2.	0.900
LOC106524050	LOC106511698	A0A2I4BZG1	A0A2I4AK92	Cell differentiation protein RCD1 homolog isoform X1.	CCR4-NOT transcription complex subunit 2-like.	0.878
LOC106524050	LOC106532462	A0A2I4BZG1	A0A2I4CVF6	Cell differentiation protein RCD1 homolog isoform X1.	Cell differentiation protein RCD1 homolog.	0.900
LOC106524050	LOC106534944	A0A2I4BZG1	A0A2I4D4T6	Cell differentiation protein RCD1 homolog isoform X1.	CCR4-NOT transcription complex subunit 2-like.	0.878
LOC106524050	cnot1	A0A2I4BZG1	A0A2I4CHE5	Cell differentiation protein RCD1 homolog isoform X1.	CCR4-NOT transcription complex subunit 1.	0.962
LOC106524050	cnot2	A0A2I4BZG1	A0A2I4B010	Cell differentiation protein RCD1 homolog isoform X1.	CCR4-NOT transcription complex subunit 2.	0.878