(55 nodes) Protein localization to chromosome network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC106532972	Zinc finger protein 827-like isoform X1. (1498 aa)
	wapl	Wings apart-like protein homolog. (1174 aa)
	LOC106511799	Uncharacterized protein LOC106511799. (324 aa)
	mis12	Protein MIS12 homolog. (222 aa)
	LOC106513525	Poly [ADP-ribose] polymerase. (1311 aa)
	LOC106513751	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (370 aa)
	LOC106513828	Intermediate filament family orphan 2-like isoform X1; Belongs to the intermediate filament family. (496 aa)
	znf827	Zinc finger protein 827. (670 aa)
	rb1	Retinoblastoma-associated protein. (915 aa)
	LOC106516406	Transcriptional regulator ATRX-like isoform X1. (1906 aa)
	bub3	Mitotic checkpoint protein BUB3. (326 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	parp3	Poly [ADP-ribose] polymerase. (583 aa)
	atrx	Transcriptional regulator ATRX. (2185 aa)
	spo11	Meiotic recombination protein SPO11. (393 aa)
	LOC106519605	Intermediate filament family orphan 1-like; Belongs to the intermediate filament family. (624 aa)
	bub1b	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. (420 aa)
	slf1	Ankyrin repeat domain-containing protein 32. (875 aa)
	iffo1	Intermediate filament family orphan 1; Belongs to the intermediate filament family. (614 aa)
	nrm	Nurim. (277 aa)
	gsg2	Serine/threonine-protein kinase haspin isoform X1. (1218 aa)
	LOC106521207	Protein zwilch homolog. (583 aa)
	LOC106521209	Protein zwilch homolog. (484 aa)
	brca2	Breast cancer type 2 susceptibility protein. (3474 aa)
	casc5	Protein CASC5. (1617 aa)
	LOC106522823	Nipped-B protein. (3091 aa)
	LOC106522993	Periphilin-1-like. (275 aa)
	spdl1	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (565 aa)
	mau2	MAU2 chromatid cohesion factor homolog. (598 aa)
	LOC106523353	Protein FAM208A-like. (1808 aa)
	LOC106523505	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
	kntc1	Kinetochore-associated protein 1 isoform X1. (2213 aa)
	mtbp	Mdm2-binding protein isoform X1. (877 aa)
	pinx1	PIN2/TERF1-interacting telomerase inhibitor 1 isoform X2. (383 aa)
	fam208a	Protein FAM208A. (1983 aa)
	LOC106525373	Aurora kinase B-like; Belongs to the protein kinase superfamily. (332 aa)
	lrwd1	Leucine-rich repeat and WD repeat-containing protein 1 isoform X1. (737 aa)
	ttk	Dual specificity protein kinase TTK. (992 aa)
	LOC106526051	DNA repair protein XRCC4-like isoform X1. (339 aa)
	nipbl	Nipped-B protein. (2549 aa)
	LOC106526439	TERF1-interacting nuclear factor 2-like. (434 aa)
	LOC106527385	Core histone macro-H2A.1; Belongs to the histone H2A family. (369 aa)
	LOC106528243	Wings apart-like protein homolog. (1216 aa)
	zw10	Centromere/kinetochore protein zw10 homolog. (764 aa)
	LOC106528669	Uncharacterized protein LOC106528669 isoform X1. (539 aa)
	LOC106528866	Protein FAM178A-like isoform X1. (1318 aa)
	pot1	Protection of telomeres protein 1 isoform X1. (837 aa)
	LOC106529502	Poly [ADP-ribose] polymerase. (1263 aa)
	terf2	Telomeric repeat-binding factor 2. (626 aa)
	LOC106537309	Transcriptional regulator ATRX-like. (889 aa)
	LOC106534956	Zinc finger protein 827-like. (556 aa)
	acd	Adrenocortical dysplasia protein homolog. (490 aa)
	atr	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2609 aa)
	LOC106533289	UPF0544 protein C5orf45 homolog isoform X1. (225 aa)
	LOC106533213	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106511799	LOC106521207	A0A2I4AKH7	A0A2I4BMZ7	Uncharacterized protein LOC106511799.	Protein zwilch homolog.	0.707
LOC106511799	LOC106521209	A0A2I4AKH7	A0A2I4BN29	Uncharacterized protein LOC106511799.	Protein zwilch homolog.	0.707
LOC106511799	LOC106525373	A0A2I4AKH7	A0A2I4C4Y4	Uncharacterized protein LOC106511799.	Aurora kinase B-like; Belongs to the protein kinase superfamily.	0.691
LOC106511799	brca2	A0A2I4AKH7	A0A2I4BP92	Uncharacterized protein LOC106511799.	Breast cancer type 2 susceptibility protein.	0.447
LOC106511799	bub3	A0A2I4AKH7	A0A2I4B418	Uncharacterized protein LOC106511799.	Mitotic checkpoint protein BUB3.	0.942
LOC106511799	casc5	A0A2I4AKH7	A0A2I4BSX9	Uncharacterized protein LOC106511799.	Protein CASC5.	0.890
LOC106511799	gsg2	A0A2I4AKH7	A0A2I4BLR1	Uncharacterized protein LOC106511799.	Serine/threonine-protein kinase haspin isoform X1.	0.439
LOC106511799	kntc1	A0A2I4AKH7	A0A2I4BYH1	Uncharacterized protein LOC106511799.	Kinetochore-associated protein 1 isoform X1.	0.787
LOC106511799	mis12	A0A2I4AKH7	A0A2I4AP56	Uncharacterized protein LOC106511799.	Protein MIS12 homolog.	0.714
LOC106511799	spdl1	A0A2I4AKH7	A0A2I4CQC7	Uncharacterized protein LOC106511799.	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family.	0.419
LOC106511799	ttk	A0A2I4AKH7	A0A2I4C742	Uncharacterized protein LOC106511799.	Dual specificity protein kinase TTK.	0.835
LOC106511799	zw10	A0A2I4AKH7	A0A2I4CGC3	Uncharacterized protein LOC106511799.	Centromere/kinetochore protein zw10 homolog.	0.695
LOC106513525	LOC106526439	A0A2I4AQT7	A0A2I4C932	Poly [ADP-ribose] polymerase.	TERF1-interacting nuclear factor 2-like.	0.509
LOC106513751	LOC106516406	A0A2I4ARS4	A0A2I4B3A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	Transcriptional regulator ATRX-like isoform X1.	0.451
LOC106513751	LOC106537309	A0A2I4ARS4	A0A2I4DD38	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	Transcriptional regulator ATRX-like.	0.451
LOC106513751	acd	A0A2I4ARS4	A0A2I4D2A4	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	Adrenocortical dysplasia protein homolog.	0.492
LOC106513751	atrx	A0A2I4ARS4	A0A2I4B9W0	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	Transcriptional regulator ATRX.	0.451
LOC106513751	parp3	A0A2I4ARS4	A0A2I4B9Q9	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	Poly [ADP-ribose] polymerase.	0.476
LOC106513751	pot1	A0A2I4ARS4	A0A2I4CJU3	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	Protection of telomeres protein 1 isoform X1.	0.492
LOC106516406	LOC106513751	A0A2I4B3A2	A0A2I4ARS4	Transcriptional regulator ATRX-like isoform X1.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.451