(34 nodes) Negative regulation of MAP kinase activity network (Austrofundulus limnaeus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	LOC106527856	Bone morphogenetic protein 4-like. (513 aa)
	LOC106529920	Dual specificity protein phosphatase 19-like. (201 aa)
	apoe	Apolipoprotein E. (251 aa)
	LOC106530585	Protein sprouty homolog 3-like. (325 aa)
	spry1	Protein sprouty homolog 1. (323 aa)
	LOC106531531	Sortilin-related receptor-like. (1150 aa)
	gba	Glucosylceramidase. (524 aa)
	LOC106531768	3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
	LOC106532687	Sortilin. (809 aa)
	sh2b3	SH2B adapter protein 3 isoform X1. (720 aa)
	LOC106534650	Neurofibromin. (2131 aa)
	spry4	Protein sprouty homolog 4. (377 aa)
	LOC106535805	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (222 aa)
	sorl1	Sortilin-related receptor. (2224 aa)
	LOC106536934	3-hydroxy-3-methylglutaryl-coenzyme A reductase-like. (148 aa)
	LOC106536933	3-hydroxy-3-methylglutaryl coenzyme A reductase. (868 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (460 aa)
	LOC106513520	Progestin and adipoQ receptor family member 3-like isoform X1. (331 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (601 aa)
	ptpn5	Tyrosine-protein phosphatase non-receptor type 5. (573 aa)
	LOC106517262	Secreted frizzled-related protein 2-like. (343 aa)
	LOC106517961	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (183 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	LOC106518866	Protein sprouty homolog 2-like. (336 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	paqr3	Progestin and adipoQ receptor family member 3. (341 aa)
	cdk5rap3	CDK5 regulatory subunit-associated protein 3. (505 aa)
	dusp10	Dual specificity protein phosphatase 10. (471 aa)
	aida	Axin interactor, dorsalization-associated protein. (304 aa)
	LOC106523125	Uncharacterized protein LOC106523125. (883 aa)
	LOC106523750	Apolipoprotein Eb-like. (265 aa)
	tmem130	Transmembrane protein 130. (308 aa)
	nf1	Neurofibromin isoform X1. (2016 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106513520	LOC106529920	A0A2I4AQT4	A0A2I4CLN2	Progestin and adipoQ receptor family member 3-like isoform X1.	Dual specificity protein phosphatase 19-like.	0.500
LOC106517961	cav3	A0A2I4B9R0	A0A2I4B9X1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.592
LOC106518866	spry1	A0A2I4BDC9	A0A2I4CPN1	Protein sprouty homolog 2-like.	Protein sprouty homolog 1.	0.622
LOC106523750	LOC106531531	A0A2I4BYB0	A0A2I4CSA6	Apolipoprotein Eb-like.	Sortilin-related receptor-like.	0.613
LOC106523750	LOC106532687	A0A2I4BYB0	A0A2I4CWA7	Apolipoprotein Eb-like.	Sortilin.	0.613
LOC106523750	LOC106535805	A0A2I4BYB0	A0A2I4D7Y4	Apolipoprotein Eb-like.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.408
LOC106523750	agt	A0A2I4BYB0	A0A2I4ANU5	Apolipoprotein Eb-like.	Angiotensinogen; Belongs to the serpin family.	0.510
LOC106523750	cav3	A0A2I4BYB0	A0A2I4B9X1	Apolipoprotein Eb-like.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.431
LOC106523750	sorl1	A0A2I4BYB0	A0A2I4D9H8	Apolipoprotein Eb-like.	Sortilin-related receptor.	0.613
LOC106529920	LOC106513520	A0A2I4CLN2	A0A2I4AQT4	Dual specificity protein phosphatase 19-like.	Progestin and adipoQ receptor family member 3-like isoform X1.	0.500
LOC106529920	paqr3	A0A2I4CLN2	A0A2I4BQQ4	Dual specificity protein phosphatase 19-like.	Progestin and adipoQ receptor family member 3.	0.500
LOC106530585	spry1	A0A2I4CNY5	A0A2I4CPN1	Protein sprouty homolog 3-like.	Protein sprouty homolog 1.	0.574
LOC106531531	LOC106523750	A0A2I4CSA6	A0A2I4BYB0	Sortilin-related receptor-like.	Apolipoprotein Eb-like.	0.613
LOC106531531	LOC106532687	A0A2I4CSA6	A0A2I4CWA7	Sortilin-related receptor-like.	Sortilin.	0.797
LOC106531531	apoe	A0A2I4CSA6	A0A2I4CMA5	Sortilin-related receptor-like.	Apolipoprotein E.	0.567
LOC106531768	LOC106536933	A0A2I4CT27	A0A2I4DBY8	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
LOC106532687	LOC106523750	A0A2I4CWA7	A0A2I4BYB0	Sortilin.	Apolipoprotein Eb-like.	0.613
LOC106532687	LOC106531531	A0A2I4CWA7	A0A2I4CSA6	Sortilin.	Sortilin-related receptor-like.	0.797
LOC106532687	apoe	A0A2I4CWA7	A0A2I4CMA5	Sortilin.	Apolipoprotein E.	0.567
LOC106535805	LOC106523750	A0A2I4D7Y4	A0A2I4BYB0	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Apolipoprotein Eb-like.	0.408