(35 nodes) Negative regulation of innate immune response network (Austrofundulus limnaeus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dcst1	DC-STAMP domain-containing protein 1. (615 aa)
	nmi	N-myc-interactor. (380 aa)
	LOC106530462	Granulins-like. (279 aa)
	mul1	Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
	dhx58	Probable ATP-dependent RNA helicase DHX58. (681 aa)
	LOC106527732	Granulins-like. (741 aa)
	irg1	Cis-aconitate decarboxylase. (529 aa)
	fam3a	Protein FAM3A. (230 aa)
	samhd1	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1. (623 aa)
	trafd1	TRAF-type zinc finger domain-containing protein 1 isoform X1. (576 aa)
	LOC106523125	Uncharacterized protein LOC106523125. (883 aa)
	cactin	Cactin. (873 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	dusp10	Dual specificity protein phosphatase 10. (471 aa)
	LOC106522272	Poly [ADP-ribose] polymerase. (1640 aa)
	grn	Granulins isoform X1. (696 aa)
	LOC106520896	Plasma protease C1 inhibitor-like; Belongs to the serpin family. (594 aa)
	atg12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (117 aa)
	LOC106518869	Granulins-like. (586 aa)
	LOC106518535	Otopetrin-1-like. (277 aa)
	LOC106518098	Cis-aconitate decarboxylase-like. (495 aa)
	adar	Double-stranded RNA-specific adenosine deaminase isoform X1. (1335 aa)
	gfer	Sulfhydryl oxidase. (196 aa)
	igf2	Insulin-like growth factor II. (215 aa)
	pias4	E3 SUMO-protein ligase PIAS4. (508 aa)
	LOC106514372	Cis-aconitate decarboxylase-like. (495 aa)
	ythdf3	YTH domain-containing family protein 3. (604 aa)
	LOC106512056	NLR family member X1-like. (172 aa)
	ythdf2	YTH domain-containing family protein 2. (639 aa)
	nlrx1	NLR family member X1. (959 aa)
	tnfaip3	Tumor necrosis factor alpha-induced protein 3. (815 aa)
	otop1	Otopetrin-1. (381 aa)
	lyar	Cell growth-regulating nucleolar protein. (346 aa)
	mettl3	N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (586 aa)
	LOC106533172	Tubulin--tyrosine ligase-like protein 12. (629 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106512056	atg12	A0A2I4AL56	A0A2I4BK60	NLR family member X1-like.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.405
LOC106512056	atg5	A0A2I4AL56	A0A2I4CAP9	NLR family member X1-like.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.410
LOC106514372	LOC106518098	A0A2I4AUA5	A0A2I4BA70	Cis-aconitate decarboxylase-like.	Cis-aconitate decarboxylase-like.	0.900
LOC106514372	irg1	A0A2I4AUA5	A0A2I4CBH9	Cis-aconitate decarboxylase-like.	Cis-aconitate decarboxylase.	0.902
LOC106518098	LOC106514372	A0A2I4BA70	A0A2I4AUA5	Cis-aconitate decarboxylase-like.	Cis-aconitate decarboxylase-like.	0.900
LOC106518098	irg1	A0A2I4BA70	A0A2I4CBH9	Cis-aconitate decarboxylase-like.	Cis-aconitate decarboxylase.	0.902
LOC106522272	dhx58	A0A2I4BSE0	A0A2I4CEW3	Poly [ADP-ribose] polymerase.	Probable ATP-dependent RNA helicase DHX58.	0.481
adar	dhx58	A0A2I4B6J7	A0A2I4CEW3	Double-stranded RNA-specific adenosine deaminase isoform X1.	Probable ATP-dependent RNA helicase DHX58.	0.449
adar	samhd1	A0A2I4B6J7	A0A2I4BYH5	Double-stranded RNA-specific adenosine deaminase isoform X1.	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1.	0.483
atg12	LOC106512056	A0A2I4BK60	A0A2I4AL56	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1-like.	0.405
atg12	atg5	A0A2I4BK60	A0A2I4CAP9	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
atg12	dhx58	A0A2I4BK60	A0A2I4CEW3	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Probable ATP-dependent RNA helicase DHX58.	0.457
atg12	nlrx1	A0A2I4BK60	A0A2I4D838	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.405
atg5	LOC106512056	A0A2I4CAP9	A0A2I4AL56	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1-like.	0.410
atg5	atg12	A0A2I4CAP9	A0A2I4BK60	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
atg5	dhx58	A0A2I4CAP9	A0A2I4CEW3	Autophagy protein 5; Involved in autophagic vesicle formation.	Probable ATP-dependent RNA helicase DHX58.	0.425
atg5	nlrx1	A0A2I4CAP9	A0A2I4D838	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.410
dhx58	LOC106522272	A0A2I4CEW3	A0A2I4BSE0	Probable ATP-dependent RNA helicase DHX58.	Poly [ADP-ribose] polymerase.	0.481
dhx58	adar	A0A2I4CEW3	A0A2I4B6J7	Probable ATP-dependent RNA helicase DHX58.	Double-stranded RNA-specific adenosine deaminase isoform X1.	0.449
dhx58	atg12	A0A2I4CEW3	A0A2I4BK60	Probable ATP-dependent RNA helicase DHX58.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.457