(12 nodes) Sympathetic nervous system development network (Austrofundulus limnaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ascl1	Achaete-scute homolog 1. (193 aa)
	hand2	Heart- and neural crest derivatives-expressed protein 2. (237 aa)
	LOC106534650	Neurofibromin. (2131 aa)
	ednra	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	LOC106527162	semaphorin-3F-like; Belongs to the semaphorin family. (750 aa)
	nf1	Neurofibromin isoform X1. (2016 aa)
	phox2b	Paired mesoderm homeobox protein 2B. (285 aa)
	diexf	Digestive organ expansion factor homolog. (749 aa)
	phox2a	Paired mesoderm homeobox protein 2A. (305 aa)
	sema3f	semaphorin-3F; Belongs to the semaphorin family. (789 aa)
	LOC106514699	Endothelin B receptor-like; Belongs to the G-protein coupled receptor 1 family. (462 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (237 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106514699	ednra	A0A2I4AVN4	A0A2I4CD60	Endothelin B receptor-like; Belongs to the G-protein coupled receptor 1 family.	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	0.901
ednra	LOC106514699	A0A2I4CD60	A0A2I4AVN4	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	Endothelin B receptor-like; Belongs to the G-protein coupled receptor 1 family.	0.901
hand2	phox2a	A0A2I4D8K2	A0A2I4B6W3	Heart- and neural crest derivatives-expressed protein 2.	Paired mesoderm homeobox protein 2A.	0.450
hand2	phox2b	A0A2I4D8K2	A0A2I4C6T8	Heart- and neural crest derivatives-expressed protein 2.	Paired mesoderm homeobox protein 2B.	0.588
phox2a	hand2	A0A2I4B6W3	A0A2I4D8K2	Paired mesoderm homeobox protein 2A.	Heart- and neural crest derivatives-expressed protein 2.	0.450
phox2b	hand2	A0A2I4C6T8	A0A2I4D8K2	Paired mesoderm homeobox protein 2B.	Heart- and neural crest derivatives-expressed protein 2.	0.588