(56 nodes) Embryonic cranial skeleton morphogenesis network (Austrofundulus limnaeus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	sec23a	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (764 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (249 aa)
	nipbl	Nipped-B protein. (2549 aa)
	mab21l2	Protein mab-21-like 2. (359 aa)
	alx1	ALX homeobox protein 1. (321 aa)
	alx3	Homeobox protein aristaless-like 3. (242 aa)
	ilvbl	Acetolactate synthase-like protein; Belongs to the TPP enzyme family. (625 aa)
	LOC106524788	ranBP-type and C3HC4-type zinc finger-containing protein 1-like. (712 aa)
	tbx1	T-box transcription factor TBX1 isoform X1. (521 aa)
	LOC106523963	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC106523830	Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa)
	LOC106522823	Nipped-B protein. (3091 aa)
	rnf2	E3 ubiquitin-protein ligase RING2. (354 aa)
	LOC106521788	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	mab21l1	Protein mab-21-like 1. (359 aa)
	shh	Sonic hedgehog protein. (276 aa)
	LOC106520852	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (557 aa)
	LOC106520361	CD166 antigen homolog A-like. (559 aa)
	nbas	Neuroblastoma-amplified sequence. (2362 aa)
	fst	Follistatin isoform X1. (350 aa)
	dlx5	Homeobox protein DLX-5. (285 aa)
	LOC106519273	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
	bmp2	Bone morphogenetic protein 2. (418 aa)
	LOC106517771	RNA-binding protein 24-like. (120 aa)
	ift140	Intraflagellar transport protein 140 homolog. (1445 aa)
	pdgfrb	Platelet-derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1095 aa)
	LOC106515813	RNA-binding protein 24. (232 aa)
	LOC106515330	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	gnptab	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. (407 aa)
	med12	Mediator of RNA polymerase II transcription subunit 12 isoform X1. (2155 aa)
	LOC106514226	Double-strand-break repair protein rad21 homolog. (637 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
	pitx2	Homeobox protein. (312 aa)
	dlx3	Homeobox protein DLX-3. (278 aa)
	LOC106511583	Intraflagellar transport protein 140 homolog. (700 aa)
	dlx2	Homeobox protein DLX-2. (276 aa)
	LOC106537001	Transcription factor GATA-3-like. (90 aa)
	hand2	Heart- and neural crest derivatives-expressed protein 2. (237 aa)
	wdr19	WD repeat-containing protein 19. (1341 aa)
	dlx1	Homeobox protein DLX-1. (253 aa)
	LOC106534862	Histone-lysine N-methyltransferase SETD2-like. (2210 aa)
	fam20b	Glycosaminoglycan xylosylkinase. (409 aa)
	LOC106534552	CD166 antigen homolog. (548 aa)
	LOC106534107	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta-like. (1258 aa)
	mmachc	Methylmalonic aciduria and homocystinuria type C protein. (263 aa)
	LOC106531229	Double-strand-break repair protein rad21 homolog isoform X1. (542 aa)
	leo1	RNA polymerase-associated protein LEO1. (743 aa)
	rad21	Double-strand-break repair protein rad21 homolog. (539 aa)
	LOC106530483	Growth arrest-specific protein 1-like. (249 aa)
	tbx10	T-box transcription factor TBX10. (317 aa)
	LOC106529465	Histone-lysine N-methyltransferase SETD2-like. (489 aa)
	LOC106529128	Sphingosine 1-phosphate receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	LOC106529061	DNA-directed RNA polymerases I and III subunit RPAC2-like. (155 aa)
	ring1	E3 ubiquitin-protein ligase RING1. (384 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	disp1	Protein dispatched homolog 1. (1539 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106511583	wdr19	A0A2I4AJV6	A0A2I4D6Q0	Intraflagellar transport protein 140 homolog.	WD repeat-containing protein 19.	0.975
LOC106514226	LOC106522823	A0A2I4ATM5	A0A2I4BUR5	Double-strand-break repair protein rad21 homolog.	Nipped-B protein.	0.863
LOC106514226	LOC106531229	A0A2I4ATM5	A0A2I4CR58	Double-strand-break repair protein rad21 homolog.	Double-strand-break repair protein rad21 homolog isoform X1.	0.902
LOC106514226	nipbl	A0A2I4ATM5	A0A2I4C8B6	Double-strand-break repair protein rad21 homolog.	Nipped-B protein.	0.863
LOC106514226	rad21	A0A2I4ATM5	A0A2I4CPG6	Double-strand-break repair protein rad21 homolog.	Double-strand-break repair protein rad21 homolog.	0.901
LOC106515330	dlx2	A0A2I4AYE0	A0A2I4AMI4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein DLX-2.	0.408
LOC106515330	dlx3	A0A2I4AYE0	A0A2I4AJ98	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein DLX-3.	0.407
LOC106515330	dlx5	A0A2I4AYE0	A0A2I4BG37	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein DLX-5.	0.405
LOC106515330	fgf3	A0A2I4AYE0	A0A2I4C9H9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.809
LOC106515330	fst	A0A2I4AYE0	A0A2I4BHJ6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Follistatin isoform X1.	0.411
LOC106515330	hand2	A0A2I4AYE0	A0A2I4D8K2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heart- and neural crest derivatives-expressed protein 2.	0.489
LOC106515330	pdgfrb	A0A2I4AYE0	A0A2I4B792	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.823
LOC106515330	shh	A0A2I4AYE0	A0A2I4BM51	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Sonic hedgehog protein.	0.615
LOC106519273	LOC106520852	A0A2I4BEZ6	A0A2I4BLH0	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.902
LOC106520361	LOC106534552	A0A2I4BJC7	A0A2I4D369	CD166 antigen homolog A-like.	CD166 antigen homolog.	0.904
LOC106520852	LOC106519273	A0A2I4BLH0	A0A2I4BEZ6	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.902
LOC106521788	LOC106523963	A0A2I4BQF9	A0A2I4BZ43	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC106521788	wnt4	A0A2I4BQF9	A0A2I4CGQ9	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.623
LOC106522823	LOC106514226	A0A2I4BUR5	A0A2I4ATM5	Nipped-B protein.	Double-strand-break repair protein rad21 homolog.	0.863
LOC106522823	LOC106529465	A0A2I4BUR5	A0A2I4CK57	Nipped-B protein.	Histone-lysine N-methyltransferase SETD2-like.	0.549