STRINGSTRING
egr1 egr1 pitx2 pitx2 dlx3 dlx3 dlx2 dlx2 LOC106514226 LOC106514226 med12 med12 gnptab gnptab bmp2 bmp2 dlx5 dlx5 fst fst nbas nbas LOC106520361 LOC106520361 shh shh LOC106521788 LOC106521788 LOC106522823 LOC106522823 LOC106523963 LOC106523963 tbx1 tbx1 nipbl nipbl wnt4 wnt4 LOC106529061 LOC106529061 LOC106529128 LOC106529128 tbx10 tbx10 rad21 rad21 LOC106531229 LOC106531229 mmachc mmachc LOC106534107 LOC106534107 LOC106534552 LOC106534552 dlx1 dlx1 hand2 hand2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
pitx2Homeobox protein. (312 aa)
dlx3Homeobox protein DLX-3. (278 aa)
dlx2Homeobox protein DLX-2. (276 aa)
LOC106514226Double-strand-break repair protein rad21 homolog. (637 aa)
med12Mediator of RNA polymerase II transcription subunit 12 isoform X1. (2155 aa)
gnptabN-acetylglucosamine-1-phosphotransferase subunits alpha/beta. (407 aa)
bmp2Bone morphogenetic protein 2. (418 aa)
dlx5Homeobox protein DLX-5. (285 aa)
fstFollistatin isoform X1. (350 aa)
nbasNeuroblastoma-amplified sequence. (2362 aa)
LOC106520361CD166 antigen homolog A-like. (559 aa)
shhSonic hedgehog protein. (276 aa)
LOC106521788Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC106522823Nipped-B protein. (3091 aa)
LOC106523963Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
tbx1T-box transcription factor TBX1 isoform X1. (521 aa)
nipblNipped-B protein. (2549 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LOC106529061DNA-directed RNA polymerases I and III subunit RPAC2-like. (155 aa)
LOC106529128Sphingosine 1-phosphate receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)
tbx10T-box transcription factor TBX10. (317 aa)
rad21Double-strand-break repair protein rad21 homolog. (539 aa)
LOC106531229Double-strand-break repair protein rad21 homolog isoform X1. (542 aa)
mmachcMethylmalonic aciduria and homocystinuria type C protein. (263 aa)
LOC106534107N-acetylglucosamine-1-phosphotransferase subunits alpha/beta-like. (1258 aa)
LOC106534552CD166 antigen homolog. (548 aa)
dlx1Homeobox protein DLX-1. (253 aa)
hand2Heart- and neural crest derivatives-expressed protein 2. (237 aa)
Your Current Organism:
Austrofundulus limnaeus
NCBI taxonomy Id: 52670
Other names: A. limnaeus
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