STRINGSTRING
LOC106523963 LOC106523963 egr1 egr1 pitx2 pitx2 LOC106511033 LOC106511033 LOC106511250 LOC106511250 LOC106511287 LOC106511287 dlx3 dlx3 LOC106511583 LOC106511583 LOC106511674 LOC106511674 LOC106511991 LOC106511991 LOC106512184 LOC106512184 LOC106512309 LOC106512309 dlx2 dlx2 hoxd3 hoxd3 sp5 sp5 LOC106513284 LOC106513284 LOC106513313 LOC106513313 LOC106513371 LOC106513371 otor otor LOC106513767 LOC106513767 LOC106513864 LOC106513864 nle1 nle1 LOC106514226 LOC106514226 sema3d sema3d LOC106514470 LOC106514470 med12 med12 gnptab gnptab LOC106514811 LOC106514811 rap1a rap1a LOC106515330 LOC106515330 fam101b fam101b kat2b kat2b LOC106515813 LOC106515813 anxa6 anxa6 hhip hhip LOC106517290 LOC106517290 pdgfrb pdgfrb ift140 ift140 LOC106517771 LOC106517771 csrnp1 csrnp1 LOC106518120 LOC106518120 dhrs3 dhrs3 msx1 msx1 atg9a atg9a bmp2 bmp2 LOC106518856 LOC106518856 LOC106518855 LOC106518855 LOC106519273 LOC106519273 dlx5 dlx5 edar edar rab23 rab23 fst fst nbas nbas LOC106520361 LOC106520361 LOC106520852 LOC106520852 wdr60 wdr60 shh shh mab21l1 mab21l1 LOC106521788 LOC106521788 p2rx7 p2rx7 zmpste24 zmpste24 rnf2 rnf2 LOC106522339 LOC106522339 LOC106522823 LOC106522823 tcf15 tcf15 LOC106523830 LOC106523830 pex7 pex7 LOC106524552 LOC106524552 hoxc9 hoxc9 hoxc4 hoxc4 tbx1 tbx1 LOC106524788 LOC106524788 serpinh1 serpinh1 tsku tsku LOC106525623 LOC106525623 ilvbl ilvbl alx3 alx3 LOC106525890 LOC106525890 scx scx alx1 alx1 mab21l2 mab21l2 nipbl nipbl foxn3 foxn3 frem1 frem1 LOC106526517 LOC106526517 fgf3 fgf3 fgf4 fgf4 disp1 disp1 LOC106527109 LOC106527109 sec23a sec23a LOC106527441 LOC106527441 LOC106527728 LOC106527728 kat2a kat2a plekha1 plekha1 wnt4 wnt4 ring1 ring1 LOC106529061 LOC106529061 LOC106529128 LOC106529128 mef2d mef2d LOC106529465 LOC106529465 LOC106529865 LOC106529865 LOC106529897 LOC106529897 tbx10 tbx10 LOC106530483 LOC106530483 LOC106530581 LOC106530581 gja1 gja1 rad21 rad21 ext2 ext2 LOC106530886 LOC106530886 leo1 leo1 LOC106531229 LOC106531229 ift80 ift80 LOC106532277 LOC106532277 LOC106532449 LOC106532449 pkd1 pkd1 sgpl1 sgpl1 ryk ryk fuz fuz mmachc mmachc LOC106533474 LOC106533474 ctgf ctgf LOC106534064 LOC106534064 LOC106534107 LOC106534107 LOC106534180 LOC106534180 sox5 sox5 LOC106534520 LOC106534520 trip11 trip11 LOC106534552 LOC106534552 LOC106534548 LOC106534548 fam20b fam20b LOC106534862 LOC106534862 dlx1 dlx1 wdr19 wdr19 LOC106535489 LOC106535489 LOC106535653 LOC106535653 LOC106535673 LOC106535673 hand2 hand2 LOC106536078 LOC106536078 LOC106536123 LOC106536123 LOC106536769 LOC106536769 fgf6 fgf6 LOC106536951 LOC106536951 LOC106537001 LOC106537001 LOC106537252 LOC106537252 LOC106537280 LOC106537280
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC106523963Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
pitx2Homeobox protein. (312 aa)
LOC106511033Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
LOC106511250AN1-type zinc finger protein 5-like. (208 aa)
LOC106511287Fibroblast growth factor 18-like isoform X1; Belongs to the heparin-binding growth factors family. (210 aa)
dlx3Homeobox protein DLX-3. (278 aa)
LOC106511583Intraflagellar transport protein 140 homolog. (700 aa)
LOC106511674Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (677 aa)
LOC106511991Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (160 aa)
LOC106512184Peroxisome proliferator-activated receptor gamma coactivator 1-beta-like. (257 aa)
LOC106512309Ras-related protein Rab-33B-like. (233 aa)
dlx2Homeobox protein DLX-2. (276 aa)
hoxd3Homeobox protein Hox-D3. (407 aa)
sp5Transcription factor Sp5. (371 aa)
LOC106513284NGFI-A-binding protein 2-like. (505 aa)
LOC106513313myoD family inhibitor-like. (304 aa)
LOC106513371Cysteine/serine-rich nuclear protein 1-like. (575 aa)
otorOtoraplin. (129 aa)
LOC106513767Peroxisome proliferator-activated receptor gamma coactivator 1-beta-like. (573 aa)
LOC106513864AN1-type zinc finger protein 5-like isoform X1. (256 aa)
nle1Notchless protein homolog 1. (478 aa)
LOC106514226Double-strand-break repair protein rad21 homolog. (637 aa)
sema3dsemaphorin-3D isoform X1; Belongs to the semaphorin family. (805 aa)
LOC106514470Transmembrane protein 119-like. (276 aa)
med12Mediator of RNA polymerase II transcription subunit 12 isoform X1. (2155 aa)
gnptabN-acetylglucosamine-1-phosphotransferase subunits alpha/beta. (407 aa)
LOC106514811Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
rap1aRas-related protein Rap-1A. (185 aa)
LOC106515330Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
fam101bFilamin-interacting protein FAM101B isoform X1. (205 aa)
kat2bHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (792 aa)
LOC106515813RNA-binding protein 24. (232 aa)
anxa6Annexin. (665 aa)
hhipHedgehog-interacting protein. (706 aa)
LOC106517290Cadherin-2-like isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (925 aa)
pdgfrbPlatelet-derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1095 aa)
ift140Intraflagellar transport protein 140 homolog. (1445 aa)
LOC106517771RNA-binding protein 24-like. (120 aa)
csrnp1Cysteine/serine-rich nuclear protein 1. (584 aa)
LOC106518120Myocyte-specific enhancer factor 2D homolog isoform X1. (574 aa)
dhrs3Short-chain dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
msx1Homeobox protein MSX-1. (287 aa)
atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (853 aa)
bmp2Bone morphogenetic protein 2. (418 aa)
LOC106518856Low-density lipoprotein receptor-related protein 5-like. (456 aa)
LOC106518855Low-density lipoprotein receptor-related protein 5-like isoform X1. (1056 aa)
LOC106519273TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
dlx5Homeobox protein DLX-5. (285 aa)
edarTumor necrosis factor receptor superfamily member EDAR isoform X1. (543 aa)
rab23Ras-related protein Rab-23. (235 aa)
fstFollistatin isoform X1. (350 aa)
nbasNeuroblastoma-amplified sequence. (2362 aa)
LOC106520361CD166 antigen homolog A-like. (559 aa)
LOC106520852TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (557 aa)
wdr60WD repeat-containing protein 60 isoform X1. (1032 aa)
shhSonic hedgehog protein. (276 aa)
mab21l1Protein mab-21-like 1. (359 aa)
LOC106521788Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
p2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (576 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
rnf2E3 ubiquitin-protein ligase RING2. (354 aa)
LOC106522339semaphorin-3D-like; Belongs to the semaphorin family. (779 aa)
LOC106522823Nipped-B protein. (3091 aa)
tcf15Transcription factor 15. (181 aa)
LOC106523830Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa)
pex7Peroxisomal biogenesis factor 7. (322 aa)
LOC106524552Homeobox protein Hox-C10a-like. (342 aa)
hoxc9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (262 aa)
hoxc4Homeobox protein Hox-C4. (266 aa)
tbx1T-box transcription factor TBX1 isoform X1. (521 aa)
LOC106524788ranBP-type and C3HC4-type zinc finger-containing protein 1-like. (712 aa)
serpinh1Serpin H1 isoform X1; Belongs to the serpin family. (444 aa)
tskuTsukushin isoform X1. (399 aa)
LOC106525623Sphingosine-1-phosphate lyase 1-like. (86 aa)
ilvblAcetolactate synthase-like protein; Belongs to the TPP enzyme family. (625 aa)
alx3Homeobox protein aristaless-like 3. (242 aa)
LOC106525890Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
scxBasic helix-loop-helix transcription factor scleraxis. (213 aa)
alx1ALX homeobox protein 1. (321 aa)
mab21l2Protein mab-21-like 2. (359 aa)
nipblNipped-B protein. (2549 aa)
foxn3Forkhead box protein N3 isoform X1. (500 aa)
frem1FRAS1-related extracellular matrix protein 1 isoform X1. (2196 aa)
LOC106526517Serpin H1-like; Belongs to the serpin family. (405 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (249 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (227 aa)
disp1Protein dispatched homolog 1. (1539 aa)
LOC106527109Polycystin-1-like isoform X1. (4187 aa)
sec23aProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (764 aa)
LOC106527441Golgi apparatus protein 1-like. (1144 aa)
LOC106527728Ras-related protein Rap-1b-like. (183 aa)
kat2aHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (797 aa)
plekha1Pleckstrin homology domain-containing family A member 1. (301 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ring1E3 ubiquitin-protein ligase RING1. (384 aa)
LOC106529061DNA-directed RNA polymerases I and III subunit RPAC2-like. (155 aa)
LOC106529128Sphingosine 1-phosphate receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)
mef2dMyocyte-specific enhancer factor 2D. (543 aa)
LOC106529465Histone-lysine N-methyltransferase SETD2-like. (489 aa)
LOC106529865Golgi apparatus protein 1-like isoform X1. (1147 aa)
LOC106529897Low-density lipoprotein receptor-related protein 6-like. (267 aa)
tbx10T-box transcription factor TBX10. (317 aa)
LOC106530483Growth arrest-specific protein 1-like. (249 aa)
LOC106530581Transcription factor SOX-5-like isoform X1. (353 aa)
gja1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (388 aa)
rad21Double-strand-break repair protein rad21 homolog. (539 aa)
ext2Exostosin-2; Belongs to the glycosyltransferase 47 family. (719 aa)
LOC106530886Transcription factor SOX-6-like isoform X1. (776 aa)
leo1RNA polymerase-associated protein LEO1. (743 aa)
LOC106531229Double-strand-break repair protein rad21 homolog isoform X1. (542 aa)
ift80Intraflagellar transport protein 80 homolog isoform X1. (796 aa)
LOC106532277Cadherin-2-like; Cadherins are calcium-dependent cell adhesion proteins. (911 aa)
LOC106532449Bone morphogenetic protein receptor type-2-like isoform X1. (391 aa)
pkd1Polycystin-1. (4609 aa)
sgpl1Sphingosine-1-phosphate lyase 1. (565 aa)
rykTyrosine-protein kinase RYK isoform X1. (627 aa)
fuzProtein fuzzy homolog. (427 aa)
mmachcMethylmalonic aciduria and homocystinuria type C protein. (263 aa)
LOC106533474Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (805 aa)
ctgfConnective tissue growth factor. (346 aa)
LOC106534064Cadherin-2-like; Cadherins are calcium-dependent cell adhesion proteins. (907 aa)
LOC106534107N-acetylglucosamine-1-phosphotransferase subunits alpha/beta-like. (1258 aa)
LOC106534180Polycystin-1. (714 aa)
sox5Transcription factor SOX-5. (787 aa)
LOC106534520AN1-type zinc finger protein 5-like. (220 aa)
trip11Thyroid receptor-interacting protein 11. (1953 aa)
LOC106534552CD166 antigen homolog. (548 aa)
LOC106534548Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
fam20bGlycosaminoglycan xylosylkinase. (409 aa)
LOC106534862Histone-lysine N-methyltransferase SETD2-like. (2210 aa)
dlx1Homeobox protein DLX-1. (253 aa)
wdr19WD repeat-containing protein 19. (1341 aa)
LOC106535489Thyroid receptor-interacting protein 11-like. (239 aa)
LOC106535653Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1057 aa)
LOC106535673Transcription factor SOX-6-like. (779 aa)
hand2Heart- and neural crest derivatives-expressed protein 2. (237 aa)
LOC106536078FRAS1-related extracellular matrix protein 1-like. (1400 aa)
LOC106536123Basic helix-loop-helix transcription factor scleraxis-like isoform X1. (226 aa)
LOC106536769Low-density lipoprotein receptor-related protein 5-like. (1384 aa)
fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
LOC106536951Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
LOC106537001Transcription factor GATA-3-like. (90 aa)
LOC106537252Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1621 aa)
LOC106537280FRAS1-related extracellular matrix protein 1-like. (1079 aa)
Your Current Organism:
Austrofundulus limnaeus
NCBI taxonomy Id: 52670
Other names: A. limnaeus
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