(64 nodes) Negative regulation of inflammatory response network (Austrofundulus limnaeus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nr1h4	Bile acid receptor isoform X1. (493 aa)
	nt5e	5'-nucleotidase; Belongs to the 5'-nucleotidase family. (571 aa)
	LOC106524427	Protein FAM19A2-like. (128 aa)
	LOC106524682	Nuclear receptor subfamily 1 group D member 1-like. (574 aa)
	fndc4	Fibronectin type III domain-containing protein 4. (220 aa)
	ghsr	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	smpdl3b	Acid sphingomyelinase-like phosphodiesterase. (461 aa)
	irg1	Cis-aconitate decarboxylase. (529 aa)
	gpr17	Uracil nucleotide/cysteinyl leukotriene receptor. (340 aa)
	LOC106527585	OX-2 membrane glycoprotein-like. (246 aa)
	LOC106527592	OX-2 membrane glycoprotein-like. (322 aa)
	LOC106527732	Granulins-like. (741 aa)
	LOC106528070	Nuclear receptor subfamily 1 group D member 1-like. (570 aa)
	LOC106528185	Uncharacterized protein LOC106528185. (1939 aa)
	LOC106528190	Peroxisome proliferator-activated receptor alpha-like. (469 aa)
	LOC106528559	Suppressor of cytokine signaling 3-like. (200 aa)
	LOC106528583	Phospholipase A(2). (152 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily member 1A. (389 aa)
	psmb4	Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
	metrnl	Meteorin-like protein. (286 aa)
	LOC106530462	Granulins-like. (279 aa)
	rabgef1	Rab5 GDP/GTP exchange factor. (510 aa)
	LOC106531171	Interleukin-20 receptor subunit alpha-like. (462 aa)
	vps35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (798 aa)
	LOC106535594	Ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1; Belongs to the peptidase C19 family. (764 aa)
	nlrx1	NLR family member X1. (959 aa)
	LOC106536532	Interleukin-20 receptor subunit alpha-like. (217 aa)
	LOC106536645	Tumor necrosis factor-inducible gene 6 protein-like. (260 aa)
	wfdc1	WAP four-disulfide core domain protein 1. (205 aa)
	nr1d2	Nuclear receptor subfamily 1 group D member 2. (570 aa)
	LOC106512056	NLR family member X1-like. (172 aa)
	il10	Interleukin-10 isoform X1. (259 aa)
	LOC106513689	Prostaglandin E2 receptor EP4 subtype-like; Belongs to the G-protein coupled receptor 1 family. (448 aa)
	mfhas1	Malignant fibrous histiocytoma-amplified sequence 1. (1028 aa)
	pparg	Peroxisome proliferator-activated receptor gamma isoform X1. (554 aa)
	LOC106513844	Tumor necrosis factor receptor superfamily member 5-like. (452 aa)
	LOC106514372	Cis-aconitate decarboxylase-like. (495 aa)
	LOC106516312	Prostaglandin E2 receptor EP4 subtype-like. (449 aa)
	rb1	Retinoblastoma-associated protein. (915 aa)
	LOC106516649	Suppressor of cytokine signaling 3-like isoform X1. (220 aa)
	cyld	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (956 aa)
	LOC106517466	Dentin sialophosphoprotein-like. (704 aa)
	LOC106518098	Cis-aconitate decarboxylase-like. (495 aa)
	LOC106518565	Leucine-rich repeat and fibronectin type-III domain-containing protein 5-like. (800 aa)
	LOC106518869	Granulins-like. (586 aa)
	LOC106518912	Bile acid receptor-like isoform X1. (490 aa)
	LOC106519399	Rab5 GDP/GTP exchange factor-like. (503 aa)
	LOC106520088	cystatin-F-like. (155 aa)
	LOC106520872	Histone-lysine N-methyltransferase ASH1L-like isoform X1. (2937 aa)
	lpcat3	Lysophospholipid acyltransferase 5 isoform X1; Belongs to the membrane-bound acyltransferase family. (465 aa)
	lrfn5	Leucine-rich repeat and fibronectin type-III domain-containing protein 5. (870 aa)
	grn	Granulins isoform X1. (696 aa)
	dusp10	Dual specificity protein phosphatase 10. (471 aa)
	LOC106523125	Uncharacterized protein LOC106523125. (883 aa)
	LOC106523980	Cadherin-5-like isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (795 aa)
	LOC106524087	Ubiquitin carboxyl-terminal hydrolase CYLD-like. (771 aa)
	nov	Protein NOV homolog isoform X1. (351 aa)
	sharpin	Sharpin. (480 aa)
	mvk	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (399 aa)
	LOC106534295	Vitamin K-dependent protein C-like. (437 aa)
	LOC106534290	Interleukin-20 receptor subunit beta-like. (415 aa)
	LOC106534516	Nuclear receptor subfamily 1 group D member 2-like. (520 aa)
	ash1l	Histone-lysine N-methyltransferase ASH1L. (1922 aa)
	tnfaip3	Tumor necrosis factor alpha-induced protein 3. (815 aa)

Your Current Organism:

Austrofundulus limnaeus

NCBI taxonomy Id: 52670
Other names: A. limnaeus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106513844	il10	A0A2I4AS38	A0A2I4APV4	Tumor necrosis factor receptor superfamily member 5-like.	Interleukin-10 isoform X1.	0.442
LOC106513844	tnfrsf1a	A0A2I4AS38	A0A2I4CIY9	Tumor necrosis factor receptor superfamily member 5-like.	Tumor necrosis factor receptor superfamily member 1A.	0.667
LOC106514372	LOC106518098	A0A2I4AUA5	A0A2I4BA70	Cis-aconitate decarboxylase-like.	Cis-aconitate decarboxylase-like.	0.900
LOC106514372	irg1	A0A2I4AUA5	A0A2I4CBH9	Cis-aconitate decarboxylase-like.	Cis-aconitate decarboxylase.	0.902
LOC106516649	LOC106528559	A0A2I4B4B6	A0A2I4CGV0	Suppressor of cytokine signaling 3-like isoform X1.	Suppressor of cytokine signaling 3-like.	0.905
LOC106516649	il10	A0A2I4B4B6	A0A2I4APV4	Suppressor of cytokine signaling 3-like isoform X1.	Interleukin-10 isoform X1.	0.427
LOC106517466	sharpin	A0A2I4B7R1	A0A2I4CVX4	Dentin sialophosphoprotein-like.	Sharpin.	0.903
LOC106518098	LOC106514372	A0A2I4BA70	A0A2I4AUA5	Cis-aconitate decarboxylase-like.	Cis-aconitate decarboxylase-like.	0.900
LOC106518098	irg1	A0A2I4BA70	A0A2I4CBH9	Cis-aconitate decarboxylase-like.	Cis-aconitate decarboxylase.	0.902
LOC106518912	LOC106534516	A0A2I4BDI3	A0A2I4D303	Bile acid receptor-like isoform X1.	Nuclear receptor subfamily 1 group D member 2-like.	0.742
LOC106518912	nr1d2	A0A2I4BDI3	A0A2I4AI71	Bile acid receptor-like isoform X1.	Nuclear receptor subfamily 1 group D member 2.	0.742
LOC106519399	rabgef1	A0A2I4BFJ9	A0A2I4CP24	Rab5 GDP/GTP exchange factor-like.	Rab5 GDP/GTP exchange factor.	0.570
LOC106519399	vps35	A0A2I4BFJ9	A0A2I4CRN1	Rab5 GDP/GTP exchange factor-like.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.630
LOC106524087	sharpin	A0A2I4BZN1	A0A2I4CVX4	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	Sharpin.	0.600
LOC106524087	tnfrsf1a	A0A2I4BZN1	A0A2I4CIY9	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	Tumor necrosis factor receptor superfamily member 1A.	0.915
LOC106528190	LOC106534516	A0A2I4CFJ1	A0A2I4D303	Peroxisome proliferator-activated receptor alpha-like.	Nuclear receptor subfamily 1 group D member 2-like.	0.607
LOC106528190	nr1d2	A0A2I4CFJ1	A0A2I4AI71	Peroxisome proliferator-activated receptor alpha-like.	Nuclear receptor subfamily 1 group D member 2.	0.612
LOC106528559	LOC106516649	A0A2I4CGV0	A0A2I4B4B6	Suppressor of cytokine signaling 3-like.	Suppressor of cytokine signaling 3-like isoform X1.	0.905
LOC106528559	il10	A0A2I4CGV0	A0A2I4APV4	Suppressor of cytokine signaling 3-like.	Interleukin-10 isoform X1.	0.427
LOC106531171	LOC106534290	A0A2I4CQZ2	A0A2I4D282	Interleukin-20 receptor subunit alpha-like.	Interleukin-20 receptor subunit beta-like.	0.900